口服钙剂时间及剂量对献血者机采血小板过程中枸橼酸钠反应的影响

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Abstract Objective To investigate the effect of oral calcium time and dose on sodium citrate reaction during platelet collection by blood donors. Methods A total of 400 blood donors who participated in platelet donation from April 2020 to March 2021 in Zhaoqing were selected as the research objects, they were divided into A, B, C, D group by random number table method, with 100 cases in each group. Group A was the control group, no intervention measures were taken before and during collection. Group B took 20 ml calcium orally 30 min before collection. In group C, 20 ml calcium was taken orally 10 min before collection. In group D, 20 ml calcium was taken orally 10 min before blood collection, 10 ml calcium was added in the middle of collection and 10 min before the end of collection. The incidence of sodium citrate reaction in four groups were observed until the end of collection. The effects of different oral calcium time and dose on the response of blood donors to sodium citrate were compared. Results There was significant difference in the incidence of sodium citrate reaction among the four groups, and the difference was statistically significant (P<0.001). The incidence of sodium citrate reaction in group A and group B was higher than that in group D, the differences were statistically significant (χ2=19.198, P＜0.001; χ2=10.288, P=0.001). There were no significant differences in the incidence of sodium citrate reaction between group A and group B, between group A and group C, between group B and group C, and between group C and group D (χ2=1.754, P=0.185; χ2=5.570, P=0.018; χ2=1.276, P=0.259; χ2=4.712, P=0.030). Conclusion Taking blood 10 min after taking 20 ml of calcium, and taking 10 ml of calcium in the middle of collection and 10 min before the end of blood collection can effectively reduce sodium citrate reaction.

Key words： Blood donation Calcium supplements Time Dose Sodium citrate reaction

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	Articles by authors
	LIANG Lihua
	CHEN Chaohong
	CHEN Cunyi
	LIANG Jiezhen
	LIAO Junyan
	LIANG Ting
	LIANG Weiying

Cite this article:

LIANG Lihua,CHEN Chaohong,CHEN Cunyi, et al. Effects of oral calcium dosage and time on sodium citrate response during platelet collection from blood donors[J]. 中国当代医药, 2022, 29(19): 35-37.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I19/35

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