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| Evaluation value of combined monitoring of bispectral index and neuron-specific enolase in the prognosis of patients with traumatic brain injury |
| QIAN Wuqiang1 2 ZHAO Ping1 2 SHI Xiaofen1 2 TANG Jianlei1 2 CUI Weiyan1 2▲ |
1. Wujin Hospital Affiliated to Jiangsu University, Jiangsu Province, Changzhou 213000, China;
2. Department of Critical Medicine, Wujin Clinical College of Xuzhou Medical University, Jiangsu Province, Changzhou 213000, China |
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Abstract Objective To explore the diagnostic value of combined monitoring of bispectral index (BIS) and neuron-specific enolase (NSE) in the prognosis of patients with traumatic brain injury. Methods A total of 60 patients with raumatic brain injury from March 2020 to July 2021 in Wujin Hospital Affiliated to Jiangsu University were selected as the research subjects. According to the Glasgow outcome scale (GOS), they were divided into the good prognosis group (n=23) and the poor prognosis group (n=37). All patients received BIS monitoring and NSE level detection. The BIS value and NSE level of the two groups of patients were compared, and the correlation between BIS value and NSE index and prognostic score, as well as the predictive value of BIS value and NSE index on the prognosis of traumatic brain injury were analyzed. Results The BIS level in the good prognosis group was higher than that in the poor prognosis group, while the NSE level in the good prognosis group was lower than that in the poor prognosis group, and the differences were statistically significant (P＜0.05). The results of correlation analysis showed that the BIS value was positively correlated with the prognostic GOS score (r=0.712, P=0.001), and the NSE level was negatively correlated with the prognostic GOS score (r=-0.606, P=0.001). Combined monitoring of BIS value and NSE index (AUC=0.93) had higher sensitivity and specificity than those of single BIS value (AUC=0.81) and NSE index (AUC=0.77) in predicting poor prognosis of traumatic brain injury. Conclusion Both BIS value and serum NSE level can reflect the prognosis quality of patients with traumatic brain injury. The lower the BIS value, the higher the NSE index, the worse the prognosis quality, and the combined monitoring is more conducive to improving the monitoring sensitivity and specificity, which is worthy of clinical promotion.
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