丙戊酸镁联合帕利哌酮治疗精神分裂症的临床效果

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Abstract Objective To evaluate the clinical effects of Magnesium Valproate combined with Paliperidone in the treatment of schizophrenia. Methods A total of 86 patients with schizophrenia treated in Jiangxi Psychiatric Hospital from October 2020 to August 2021 were selected as research objects, and they were divided into control group (43 cases) and observation group (43 cases) according to random number table method. The control group was treated with Paliperidone, and the observation group was treated with Magnesium Valproate combined with Paliperidone. The course of treatment was three months. The clinical efficacy, positive and negative symptom score (PANSS), global assessment function (GAF) score, social disability screening schedule (SDSS) score, thiobarbituric acid reactive substances (TBARS), brain-derived neurotrophic factor (BDNF), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). After treatment, GAF score of the two groups was higher than that before treatment, PANSS score and SDSS score of the two groups were lower than those before treatment, and GAF score of the observation group was higher than that of the control group, PANSS score and SDSS score of the observation group were lower than those of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of TBARS, TNF-α and IL-1β in two groups were lower than those before treatment, the level of BDNF in two groups was higher than that before treatment, and the levels of TBARS, TNF-α and IL-1β in the observation group were lower than those in the control group, the level of BDNF in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Magnesium Valproate combined with Paliperidone is effective in the treatment of schizophrenia.

Key words： Magnesium Valproate Paliperidone Schizophrenia Thiobarbituric acid reactive substances Brain-derived neurotrophic factor

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	Articles by authors
	LI Shujuan
	HU Jing
	TU Gangying
	LI Junyi

Cite this article:

LI Shujuan,HU Jing,TU Gangying, et al. Clinical effects of Magnesium Valproate combined with Paliperidone in the treatment of schizophrenia[J]. 中国当代医药, 2022, 29(19): 81-84.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I19/81

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