Objective To investigate the effect of microRNA-501-5p(miR-501-5p)in breast cancer.Methods Forty patients with breast cancer diagnosed for the first time in Tumor Hospital of Mudanjiang City from March 2020 to March 2021 were selected as the breast cancer group. Forty physical examination subjects in Hongqi Hospital Affiliated to Mudanjiang Medical University during the same period were selected as the healthy control group. Serum of patients in the two groups was collected, and the expression level of miR-501-5p was detected by real-time fluorescence quantitative PCR (qRT-PCR). The expression of LAMTOR5 in tissues was detected by immunohistochemistry. ROC curve was drawn to analyze the value of serum miR-501-5p, carcinoembryonic antigen (CEA), carbohytrate antigen 153(CA153) and carbohytrate antigen 125 (CA125) in the diagnosis of breast cancer. Results The expression level of miR-501-5p in breast cancer tissue (1.12±0.23) was higher than that in adjacent tissues (0.96±0.15), and the difference was statistically significant (P<0.05). The expression level of miR-501-5p in serum of breast cancer patients (0.96±0.67)was higher than that of healthy controls (0.88±0.12), and the difference was statistically significant (P<0.05). The expression level of miR-501-5p in patients with lymph node metastasis and TNM stage Ⅲand Ⅳwere higher than those in patients with TNM stage Ⅰand Ⅱwithout lymph node metastasis, and the differences were statistically significant (P<0.05). The positive rate of LAMTOR5 expression in breast cancer tissue was higher than that in adjacent tissues, and the difference was statistically significant (P<0.05). The AUC of serum miR-501-5p, CEA, CA153 and CA125 in the diagnosis of breast cancer was 0.663, 0.827, 0.687 and 0.633,respectively, and the AUC of four combined diagnosis of breast cancer was 0.877. Conclusion The expression of miR-501-5p is increased in breast cancer tissues and serum of breast cancer patients,and its expression is related to lymph node metastasis and clinical TNM stage of breast cancer.The positive expression of LAMTOR5 in breast cancer tissues was higher than that in adjacent tissues.The expression of LAMTOR5 was positively correlated with the expression level of miR-501-5p. Combined detection of miR-501-5p, CEA, CA153 and CA125 can improve the diagnostic level of breast cancer.

 Objective To investigate the expression and role of gross cystic disease fluid protein-15 (GCDFP-15) in lung cancer. Methods The cancer genome atlas (TCGA) database was used to analyze the differences in the expression of GCDFP-15 in lung cancer tissues and adjacent tissues; the differences in the expression of GCDFP-15 in lung cancer patients with different clinical stages and then to compare the survival time of lung cancer patients in the GCDFP-15 high/low expression group. GCDFP-15 levels in plasma of lung cancer patients and control group were detected by enzyme-linked immunosorbent assay (ELISA). Quantitative reverse transcription PCR (RT-qPCR) and Western blot were used to detect the expression of GCDFP-15 mRNA and protein in 4 lung cancer cell lines and 1 bronchial epithelial cell line, respectively. The concentration of GCDFP-15 in the supernatant of culture medium of the above 5 cell lines was detected by ELISA, and the expression of GCDFP-15 in lung cancer was comprehensively analyzed.Results TCGA database showed that there were no statistically significant differences in the expression of GCDFP-15 in lung adenocarcinoma and squamous cell carcinoma, the expression of GCDFP-15 in lung cancer patients with different clinical stages, and the median survival between low expression group and high expression group (P>0.05). The plasma concentration of GCDFP-15 in lung cancer group was higher than that in normal control group, and the difference was statistically significant (P<0.05). The GCDFP-15 mRNA of 4 lung cancer cell lines was higher than that of bronchial epithelial cells, and the difference was statistically significant (P<0.05). Western Blot results showed that GCDFP-15 protein was not detected in all the 5 cell lines, and GCDFP-15 was detected in the supernatant of cell culture medium, and the expression of GCDFP-15 in the supernatant of A549 and H620 medium was higher than that of 16HBE in all the 4 lung cancer cell lines, the difference was statistically significant (P＜0.05). Conclusion GCDFP-15 in plasma of lung cancer patients was higher than that of normal control group, GCDFP-15 mRNA in 4 lung cancer cell lines was significantly higher than that of bronchial epithelial cell lines, GCDFP-15 in supernatant of culture medium of 2 lung cancer cell lines was higher than that of bronchial epithelial cell lines. Combined with the results of TCGA database analysis, it is speculated that GCDFP-15 may be a tumor marker of lung cancer.

Objective To analyse vitamin D, Procalcitionin（PCT）, C-reactive protein（CRP） level of Premature rupture of membranes neonatal cord blood and relation of neonatal early-onset sepsis. Methods A total of 105 cases of parturients admitted to the Baiyun Branch of Nanfang Hospital of Southern Medical University from May 2019 to October 2020 were retrospectively selected as the observation objects, according to whether maternal premature rupture of membranes occurred was divided into premature rupture group (n=45) and control group (n=60). The differences of neonatal umbilical cord blood vitamin D, PCT, CRP levels between premature rupture group and control group were compared, the differences of neonatal umbilical cord blood vitamin D, PCT, CRP levels in premature rupture group between neonatals with and without early-onset sepsis were compared, the correlation of umbilical cord vitamin D,PCT, CRP levels between premature fetal membrane rupture and early-onset sepsis were analyzed. Results The level of vitamin D in premature rupture group was lower than control group, the levels of PCT, CRP in premature rupture group were higher control group, and the differences were statistically significant (P<0.05). The cord blood vitamin D level of neonates with early onset sepsis in the premature rupture group was lower than that of the neonates without early onset sepsis in the premature rupture group，and cord blood PCT, CRP of neonates with early onset sepsis in premature rupture group were higher than those of neonates without early onset sepsis in premature rupture group, and the differences were statistically significant (P<0.05). Correlation analysis showed that neonatal umbilical cord blood vitamin D level was negatively correlated with early onset sepsis, PCT, CRP was positively correlated with early onset sepsis (P＜0.05). Conclusion Low neonatal cord blood vitamin D in neonatals with increased PCT, CRP level is related to early-onset sepsis after childbirth. Prevent low vitamin D level during pregnancy. Monitoring PCT, CRP level can reduce the probability of premature hairstyle sepsis, which has positive significance to neonatal prognosis.

The application of interbody implants in spinal surgery can promote the fusion between vertebral bodies of spine. In recent years, with the increase of the number of spinal fusion operations, a large number of studies have been devoted to optimizing the mechanical and biological characteristics of interbody implants to promote bone fusion. The earliest used interbody implant was made of autologous cortical bone. At present, titanium alloy and polyether ether ketone (PEEK) are the two most widely used and common materials in application and research. Although the elastic modulus of titanium is much higher than that of natural bone, its bone integration performance is better than PEEK.The elastic modulus of PEEK is close to that of bone, but it does not have some excellent biological properties of titanium. Increasing the porosity and surface roughness of titanium implants can improve the mechanical properties of titanium implants, while the biological properties of PEEK can be enhanced by surface coating technology using titanium or hydroxyapatite. Using additive manufacturing technology and some metals with antibacterial activity can improve the material properties from another point of view, so as to further improve the performance of implants. This review focuses on the recent research progress of titanium alloy and PEEK implant material modification and surface treatment technology, aiming to provide reference for improving the fusion rate of spine surgery.

In order to meet professional postgraduate training requirements and development of the nursing industry, it is an important measures to train part-time nursing professional degree masters into high-level specialist practical nursing talents. The master degree of part-time nursing professional degree emphasizes professional practice ability, and has similarities with the training of professional nurses. At the same time, the two training can reduce the waste of time, human resources, and help the better development of nursing career in China. It is necessary to strengthen and improve the top-level design of the combined training for part-time nursing master′s degree and specialized nurses, actively promote the homogeneous training system for specialized nurses, and further promote the cooperation between the government, colleges and medical institutions, and promote the implementation of the combined training policy and the classified and orderly promotion of the combined training. This article explore the combined training model by expounding the status quo and advantages of the combined training of the two. It is expected to provide ideas for the joint training of senior nursing practice talents between universities and the industry.

Traditional Chinese Medicine was born in ancient China. It was due to the contemporary characteristics of the time that numerous traditional Chinese medicine physicians adopted the philosophical approach of simple materialism from the macroscopic perspective of harmony between the heaven and human. From the holistic viewpoint of the human body, they conduct in-depth thinking and summarize both the health of human life and disease evolution, and therefore the unique and systematic traditional Chinese medicine theory has been formed. Chinese medicine has made a great contribution to the treatment of acute cerebral infarction and has benefited mankind. In order to clarify the research status of traditional Chinese medicine treatment of acute cerebral infarction in recent 5 years, this research reviewed and analyzed the literature on the treatment of acute cerebral infarction with traditional Chinese medicine in recent 5 years. Literature mainly came from CNKI, Wanfang Data Knowledge Service Platform and PubMed website.Cerebral infarction, ischemic stroke and traditional Chinese medicine were selected as the key words. Then the traditional Chinese medicine clinical literature of acute cerebral infarction was extracted and sorted out. Through combing and analyzing the literature on the traditional Chinese medicine treatment of acute cerebral infarction during recent five years, this article will further discuss the latest development in the traditional Chinese medicine treatment of acute cerebral infarction, and provide reference for the traditional Chinese medicine clinical practice of acute cerebral infarction, so as to improve the clinical treatment effect of acute cerebral infarction. In this study, it is found that the current research programs of Chinese medicine in the treatment of acute cerebral infarction are based on the comprehensive treatment of Chinese medicine on the basis of modern medicine, and there are few reports on the use of single characteristic treatment measures of Chinese medicine, and the research level is uneven.

Objective To investigate the clinical efficacy of high-dose Gamma Globulin combined with Dexamethasone in the treatment of children with immunologic thrombocytopenic purpura (ITP). Methods A total of 71 children with ITP admitted to Hubei Provincial Geological Staff Hospital from January 2019 to January 2021 were selected as the research objects, and the patients were divided into the observation group (n=36, the number is an odd number) and the control group (n=35, the number is an even number). The control group was treated with Dexamethasone, and the observation group was treated with high-dose Gamma Globulin on the basis of the control group. The clinical efficacy of the two groups after treatment and the expression levels of CD3+, CD4+CD25+Treg in the two groups before and after treatment were compared. At the same time, the platelet count, the peak time of platelet count and the length of hospital stay were recorded in the two groups before and after treatment. Results The total effective rate of the observation group after treatment was significantly higher than that of the control group, the difference was statistically significant(P＜0.05). The CD3+and CD4+CD25+Treg of the observation group after treatment were significantly higher than those of the control group, the differences were statistically significant (P＜0.05). The platelet count of the observation group after treatment was higher than that of the control group, and the peak time of platelet count and the time of hospitalization in the observation group were significantly shorter than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Dexamethasone combined with high-dose Gamma Globulin can improve the therapeutic effect of children with ITP, and can adjust the body′s immune function indexes, shorten the peak time of platelet count,increase platelet count, and shorten the hospital stay of children.

 Objective To investigate the efficacy of Tirofiban combined with Atorvastatin and dual antiplatelet drugs in patients with coronary atherosclerotic heart disease after percutaneous coronary intervention (PCI). Methods A total of 106 patients with coronary atherosclerotic heart disease who underwent PCI in Shenyang First People′s Hospital from March 2018 to June 2020 were selected and divided into the experimental group (53 cases) and the reference group(53 cases) by computer random number table methods according to the number of visits. The control group was treated with Clopidogrel, Aspirin and Atorvastatin after surgery, and the experimental group was treated with Tirofiban on the basis of the reference group. The cardiac function (left ventricular end-diastolic diameter [LVEDD], left ventricular end-systolic diameter [LVESD], left ventricular ejection fraction [LVEF]), platelet activating factor (PAF), growth differentiation factor 15 (GDF-15) before and after treatment and the incidence of major adverse cardiac events (MACE) at 3 months after surgery were compared between the two groups. Results After treatment, the levels of LVESD, LVEDD,PAF, and GDF-15 in the experimental group were lower than those in the reference group, and the level of LVEF in the experimental group was higher than that in the reference group, and the differences were statistically significant (P<0.05). The incidence of MACE in the experimental group at 3 months after surgery was lower than that in the reference group, the difference was statistically significant (P<0.05). Conclusion Tirofiban combined with Atorvastatin and dual antiplatelet drugs is effective in the treatment of patients with coronary atherosclerotic heart disease after PCI, which can effectively improve cardiac function and reduce the risk of MACE.

Objective To explore the application effect of different doses of Prednisone in the treatment of granulomatous mastitis (GLM). Methods From January 2015 to January 2020, 100 patients with GLM admitted to the Department of Galactophore of Huizhou Second Maternity and Child Health Hospital were selected as the research objects, and they were divided into the experimental group (n=50) and the control group (n=50) by random number table method. The experimental group was treated with Prednisone with an initial dose of 0.4 mg/(kg·d) and decreasing with the course of treatment (the dose decreased by 2.5 mg/d per week after 5 weeks of treatment), and the control group was treated with Prednisone with an initial dose of 0.75 mg/(kg·d) and decreasing with the course of treatment (the dose decreased by 5 mg/d per week after 5 weeks of treatment). Both groups of patients were treated with debridement within 6 to 8 weeks of treatment. The effect of drug treatment and the incidence of adverse reactions, surgery-related indicators and followup related indicators were compared between the two groups. Results There was no significant difference in the effective rate of drug treatment between the two groups (P＞0.05). The incidence rates of stomach discomfort, menstrual disorders, elevated blood sugar, and insomnia in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the incidence of acne and weight gain between the two groups (P＞0.05). There was no significant difference in the preoperative medication time,intraoperative gland removal amount and recovery time after treatment between the two groups (P＞0.05). There were no statistically significant differences in the total incidence of postoperative complications and the recurrence rate of 1 year follow-up between the two groups (P>0.05). Conclusion There is no difference in the drug efficacy of different doses of prednisone in the treatment of granulomatous mastitis, and it has no effect on the follow-up surgical treatment and recurrence rate. However, low-dose Prednisone in the treatment of granulomatous mastitis can effectively reduce the adverse drug reactions of patients, which is worthy of further study.

 Objective To investigate the application effect of stepped decompression under intracranial pressure monitoring and conventional large bone flap decompression in the treatment of severe craniocerebral trauma. Methods The clinical data of 60 patients with severe craniocerebral trauma treated in Fengcheng Hospital of Fengxian District from January 2020 to December 2021 were analyzed retrospectively. According to different treatment methods, they were divided into the control group (30 cases) and the observation group (30 cases). The control group was treated with conventional large bone flap decompression, and the observation group was treated with stepped decompression under intracranial pressure monitoring. The operation condition, CT sellar temporal muscle thickness, the change of intracranial pressure, Glasgow coma scale (GCS) score, Mannitol application condition and the incidence of complications were compared between the two groups. Results The initial decompression time and ICU hospitalization time in the observation group were shorter than those in the control group, the amount of intraoperative bleeding in the observation group was less than that in the control group, the differences were statistically significant (P＜0.05). There were no significant differences in the CT sellar temporal muscle thickness and intracranial pressure between the two groups (P＞0.05). The CT sellar temporal muscle thickness in the two groups were higher than those before operation, and the intracranial pressure in the two groups were lower than those before operation, the differences were statistically significant (P＜0.05).The CT sellar temporal muscle thickness and intracranial pressure in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the GCS score before operation between the two groups (P＞0.05).The GCS scores of the two groups after operation were higher than those before operation, and the differences were statistically significant (P＜0.05). The GCS score of the observation group after operation was higher than that of the control group, the difference was statistically significant (P＜0.05). The application time of mannitol in the observation group was shorter than that in the control group, and the application dose of Mannitol in the observation group was lower than that in the control group, and the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Step decompression under intracranial pressure monitoring is more effective in the treatment of severe craniocerebral trauma. It can accelerate the decrease of intracranial pressure, reduce the application dose of Mannitol, promote the recovery of GCS score, shorten the length of stay in ICU and reduce the risk of complications.

Objective To analyze the clinical effect of Maqin Xiaoke Granules on acute cough. Methods A total of 80 patients with acute cough admitted in the Donghua Donghua Hospital from March 2020 to March 2021 were selected as the research subjects for a retrospective analysis. According to different therapeutic methods, they were divided into a conventional group (n=40) and a treatment group (n=40). The patients in the conventional group were treated with Compound Pseudoephedrine Hydrochloride Solution, and the patients in the treatment group were treated with Maqin Xiaoke Granules. The treatment effect, traditional Chinese medicine syndrome score, pulmonary function, number of coughs within 2 min and the occurrence of adverse reactions were compared between the two groups. Results The total effectiveness rate of treatment in the treatment group was 85.00%, higher than that in the conventional group accounting for 60.00%, and the difference was statistically significant (P<0.05). There were no significant differences in traditional Chinese medicine syndrome scores of cough, expectoration, fever, asthma, daytime cough and night cough before treatment between the two groups (P>0.05). After treatment, the traditional Chinese medicine syndrome scores of cough, expectoration, fever, asthma, daytime cough and night cough in the treatment group after treatment were lower than those in the conventional group, and the traditional Chinese medicine syndrome scores of cough, expectoration,fever, asthma, daytime cough and night cough in the two groups after treatment were lower than those in the same group before treatment, and the differences were statistically significant (P<0.05). There were no significant differences in the levels of forced vital capacity (FVC), forced expiratory volume in one second (FEV1) or peak expiratory flow (PEF) between the two groups before treatment (P>0.05). The levels of FVC, FEV1, and PEF after treatment in the treatment group were higher than those in the conventional group, and the levels of FVC, FEV1, and PEF in the two groups after treatment were higher than those before treatment, and the differences were statistically significant (P<0.05). The number of coughs within 2 min in the two groups before treatment did not show statistical significance (P＞0.05). After treatment, the number of coughs within 2 min in the treatment group was less than that in the conventional group, and the number of coughs in the two groups within 2 min after treatment was less than that before treatment in the same group,and the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in the treatment group was 7.50%, which was not significantly different from that in the conventional group, 12.50% (P＞0.05). Conclusion The application of Maqin Xiaoke Granules has a remarkable therapeutic effect. It can effectively promote the disappearance of related symptoms, reduce the traditional Chinese medicine syndrome score, and play a good role in protecting and improving lung function, and reducing the number of coughs in high safety. There are few adverse reactions after medication, which is of great significance in the clinical treatment of acute cough, and has high clinical therapeutic value. It is recommended to be adopted and promoted.

Objective To compare the effect of totally extraperitoneal hernia repair (TEP) and transabdominal preperitoneal hernia repair (TAPP) on patients′ groin pain, sexual function and quality of life. Methods A total of 88 patients with inguinal hernia in Xishan District Hospital of Traditional Chinese Medicine from January 2018 to December 2020 were selected as research objects, they were divided into TEP group and TAPP group according to computer random number table method, with 44 cases in each group. Patients in the TEP group underwent TEP, and patients in the TAPP group underwent TAPP. The sexual function and quality of life were compared between the two groups before surgery, 3 and 6 months after surgery, as well as groin pain was compared between the two groups before surgery, at 1,6, 24 h, 1 week, 1, 3 and 6 months after surgery. Results The sexual function and quality of life postoperatively of two groups after surgery were higher than those before surgery, the differences were statistically significant (P<0.05). However, there were no significant differences in sexual function and quality of life between two groups before and after surgery (P>0.05). The groin pain of the two groups at 3 and 6 months after surgery were lower than those before surgery, the differences were statistically significant (P<0.05). The groin pain in the TEP group was lower than that in the TAPP group at 6, 24 h, 1 week and 1 month after surgery, the difference was statistically significant (P＜0.05). There were no significant differences in groin pain between two groups at 1 h, 3 and 6 months after surgery (P＞0.05). Conclusions TEP and TAPP can improve the sexual function, quality of life and groin pain. The early postoperative groin pain score in the TEP group is lower than that in the TAPP group, but TEP and TAPP repairs are comparable in terms of these long-term outcomes.

Objective To investigate the efficacy and safety of low-collar small incision minimally invasive technique in the treatment of benign thyroid tumors. Methods Sixty patients who underwent surgical treatment of benign thyroid tumors in the First People′s Hospital of Jingdezhen City from July 2020 to July 2021 were selected as research objects,they were divided into control group and observation group according to random number table method, with 30 cases in each group. Patients in control group received thyroidectomy, and patients in observation group received low-collar small incision surgery. Compare the effect of surgical treatment between two groups, compare the general operation conditions (including surgical incision length, operation time, intraoperative blood loss, postoperative hospital stay, etc.),compare the prognosis scores (visual analogue scale [VAS], postoperative quality score) and record postoperative bleeding, dyspnea and other complications. Results The clinical effective rate of surgical treatment in observation group was higher than that in control group,and the difference was statistically significant(P<0.05).The surgical incision length,operation time, and postoperative hospital stay of observation group were shorter than those in control group, the intraoperative blood loss was less than that in control group, the VAS score of observation group was lower than that of control group, and the scores of physical function, social function, mental function and mental life of observation group were higher than those of control group, and the differences were statistically significant (P<0.05). The total incidence of postoperative complications in observation group was lower than that in control group, and the difference was statistically significant(P<0.05).Conclusion The clinical effect of low-collar small incision in the treatment of patients with benign thyroid tumors is better than traditional resection, and the surgical incision is small, the whole body impact is little, and the hospital stay can be shortened, the postoperative quality of life is higher, and postoperative complications occur less, it is worthy of clinical application and reference.

Objective To investigate the effect of thoracoscopic lobectomy (PLT) in the treatment of non-small cell lung cancer (NSCLC) and the effects of interleukin-6 (IL-6), interleukin-10 (IL-10), hypersensitive C-reactive protein (hs-CRP) and stress levels. Methods A total of 138 NSCLC patients who received surgical treatment in Central Hospital of Chaoyang City from February to November 2020 were selected as the research subjects, and were divided into observation group and control group according to random number table method, with 69 cases in each group. The observation group was treated with PLT, and the control group was treated with traditional thoracotomy. The treatment effect, IL-6,IL-10, hs-CRP and stress index levels before and 5 d after surgery were compared between the two groups. Results The duration of operation and hospital stay in the observation group were shorter than those in the control group, the differences were statistically significant (P<0.05). The levels of IL-6, IL-10 and hs-CRP in both groups were higher than before 5 days after operation, but the levels of IL-6, IL-10 and hs-CRP in observation group were lower than control group, the differences were statistically significant (P<0.05). The levels of substance P, growth hormone and cortisol 5 days after operation in both groups were higher than before treatment, but the levels of substance P, growth hormone and cortisol in observation group were lower than those in control group, the differences were statistically significant (P<0.05). Conclusion PLT operation is effective in treating NSCLC patients. It can also improve the inflammatory response and stress state of the body after operation, it′s worth promoting.

Objective To investigate the clinicopathological features associated with axillary lymph node metastasis in invasive breast cancer, and to provide reference factors for preoperative prediction of axillary lymph node metastasis in breast cancer. Methods The clinical data of 70 patients with invasive breast cancer admitted to Dalian Women and Children Medical Center (Group) Sports New Town Campus from December 2019 to March 2021 were retrospectively analyzed. The information of patients′ age, tumor size, pathological type, molecular type, pathological grade, number of primary tumor foci, micropapillary structure and vascular invasion were collected. The risk factors for axillary lymph node metastasis were analyzed by multivariate analysis. Results Among 70 patients with breast invasive cancer, 29 cases had axillary lymph node metastasis and 41 cases had no metastasis. There were statistically significant differences in tumor size and vascular invasion between the metastatic group and the non-metastatic group (P＜0.05). There were no significant differences in age, pathological type, molecular type, pathological grade, number of primary tumor foci and whether accompanied by micropapillary structure between the two groups (P＞0.05). Multivariate analysis showed that the tumor size was ≥3.5 cm (β=1.829, OR=6.226, P=0.021, 95%CI=1.315～29.490) and vascular infiltration (β=2.578,OR=13.171, P ＜0.001, 95%CI=3.861 ～44.937) were independent risk factors for axillary lymph node metastasis.Conclusion Tumor size (≥3.5 cm) and vascular invasion are independent risk factors for axillary lymph node metastasis in breast cancer. And precise treatment of breast cancer patients can be achieved according to the risk factors.

 Objective To study the effect of screw acupuncture therapy on postpartum blood pressure of hypertensive disorder complicating pregnancy. Methods A total of 100 postpartum patients with gestational hypertension admitted to Jiangxi Maternal and Child Health Hospital from January to August 2021 were selected as the research subjects. They were divided into observation group and control group by random number table method, with 50 patients in each group.Control group was treated with conventional antihypertensive drugs, observation group was treated with antihypertensive drugs combined with screw acupuncture. The blood pressure control level, blood pressure recovery time, urinary protein turning negative time and the total incidence of complications were compared between the two groups. Results After treatment, systolic blood pressure (SBP), diastolic blood pressure (DBP) and central venous pressure (MAP) levels in observation group were lower than those in control group, the differences were statistically significant (P＜0.05). The levels of SBP, DBP and MAP in the two groups after treatment were lower than those before treatment, the differences were statistically significant (P＜0.05). The recovery rates of blood pressure and urinary protein in the two groups at 3 months postpartum were higher than those at 1 month postpartum, the differences were statistically significant (P＜0.05). The recovery rate of blood pressure and urine protein in the observation group were higher than those in the control group at 3 months postpartum, the differences were statistically significant (P＜0.05). There were no statistically significant differences in the incidence rates of infection, fat liquefaction, shortness of breath, insomnia, acupuncture cramps and other complications between the two groups (P＞0.05). Conclusion Screw acupuncture treatment can obviously improve postpartum blood pressure abnormality of hypertensive disorder complicating pregnancy, and has a wide clinical application prospect.

 Objective To analyze the prophylactic effect and the cost-effectiveness of Carmine Leaf Granules on the colds of chlildren in "families of two children" and evaluate its clinical promotional value in preventing the colds in children. Methods From October 2020 to March 2021, 112 cases of children with cold in the emergency department of the Children′s Hospital of Jiangxi Province, another child with a possible history of cold exposure was selected as the research object. The subjects were randomly divided into study group and control group by drawing lots, with 56 cases in each group. In the study group, Carmine Leaf Granules were taken orally, and Oseltamivir Granules were also taken orally if the children in the family were suffering from influenza. The control group did not do intervention. If the children in this family were treated with influenza, Oseltamivir Granules were taken orally. All the children were treated with Carmine Leaf Granules oral plus symptomatic treatment. The incidence of colds, total cost, per capita cost and percentage of people without colds within 1 week were compared between the two groups, and a cost-benefit analysis was conducted. Results In 112 cases, the remission rate of cold was 81.25%. There were no significant differences in age, gender and malnutrition between the study group and the control group (P>0.05). The incidence of cold in the study group was lower than that in the control group, and the difference was statistically significant (P<0.05). The costbenefit ratio of the study group was lower than that of the control group. Conclusion Carmine Leaf Granules has good preventive value and cost-effectiveness on the colds of chlildren.

Objective To analyze the changes and clinical significance of intestinal flora in patients with gestational diabetes mellitus (GDM). Methods A total of 100 GDM patients who underwent labor examination and delivery in Shiyan People′s Hospital of Bao′an District in Shenzhen City from September 2020 to June 2021 were selected as the GDM group. In addition, 80 normal pregnant women in the same period were selected as the normal pregnancy group to compare the intestinal flora of the two groups of pregnant women and adverse pregnancy outcomes of their mothers and infants. According to the maternal and infant pregnancy outcomes of GDM women, they were divided into the normal delivery group and the adverse pregnancy group to compare the intestinal flora detection results of the two groups. Results The colonies of Enterobacter and Enterococcus in GDM group were higher than those in normal pregnancy group,while the colonies of Bifidobacteria and Lactobacillus were lower than those in normal pregnancy group, the differences were statistically significant (P<0.05). The incidence of adverse pregnancy in GDM group was higher than that in normal pregnancy group, and the difference was statistically significant (P<0.05). The colonies of Enterobacter and Enterococcus in the adverse pregnancy group were higher than those in the normal delivery group, while the colonies of Bifidobacteria and Lactobacillus were lower than those in the normal delivery group, the differences were statistically significant (P<0.05). Conclusion Patients with GDM have intestinal flora disorder, and the incidence of maternal and infant adverse pregnancy outcomes is higher. Monitoring the changes of intestinal flora in patients with GDM has certain significance for clinical prevention and treatment of GDM and improvement of maternal and infant outcomes.

Objective To investigate the application effect of Inosine Tablets combined with Topiramate in children with transient tic disorder (TTD). Methods The clinical data of 86 children with TTD admitted to the Outpatient Department of Jiangmen Central Hospital of Guangdong Province from February 2019 to February 2021 were retrospectively analyzed. They were divided into a control group (43 cases) and an observation group (43 cases) according to different treatment methods. The children in the control group were treated with Inosine Tablets, and the children in the observation group were additionally treated with Topiramate. Both groups were treated for 24 weeks. The clinical efficacy, Yale global tie severityb scale (YGTSS) score, attention deficit hyperactivity disorde (ADHD) score, daily tic times and adverse reactions were compared between the two groups. Results The total effectiveness rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05).There was no significant difference in the YGTSS score between the two groups before treatment (P>0.05). The items and total YGTSS scores of the observation group were lower than those before treatment, and the differences were statistically significant (P<0.05). The items and total YGTSS scores in the observation group after treatment were lower than those in the control group, with statistical significances (P<0.05). There were no significant differences in ADHD scores between the two groups before treatment (P>0.05). After treatment, the scores of attention deficit, hyperactivity and impulsivity and total ADHD scores of the two groups were lower than those before treatment, the differences were statistically significant (P<0.05). The attention deficit, hyperactivity and impulsivity scores and total ADHD score of the observation group were lower than those of the control group after treatment, the differences were statistically significant (P<0.05). There was no significant difference in the number of daily tic before treatment between the two groups (P＞0.05). The number of daily convulsions in the two groups after treatment was less than that before treatment, the difference was statistically significant (P＜0.05). The number of daily convulsions in the observation group was less than that in the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Inosine Tablets combined with Topiramate can improve the therapeutic effect of TTD in children, reduce the YGTSS score and ADHD score, and reduce the number of daily tics. It is safe and reliable, and is worthy of wide application.

Objective To investigate the effect of Cefazolin combined with Metronidazole in the perioperative period of patients with oral and maxillary cysts. Methods A total of 90 patients with oral and maxillary cysts who were admitted to the Affiliated Stomatological Hospital of Nanchang University from January 2019 to October 2021 were selected as the research objects,and they were divided into group A(30 cases),group B(30 cases)and group C (30 cases) by random number table method. The group A were not treated with any antibiotics, and group B treated with Cefazolin alone, and group C was treated with Cefazolin combined with Metronidazole. The clinical signs related indicators such as white blood cells, neutrophils, C-reactive protein (CRP), body temperature and the incidence of postoperative infection were compared among the three groups before and after treatment. Results After treatment, there were no significant differences in the leukocytes, neutrophils, CRP, body temperature and other physical indicators among the three groups (P>0.05). There was no significant difference in the incidence of postoperative infection among the three groups (P>0.05).Conclusion In the case of patients with oral and maxillofacial cysts with good immune function, the absence of antibiotics for assisted surgical treatment during the perioperative period will not lead to changes in the patients′ physical signs and immune function, nor will it increase the risk of postoperative infection in the patients. Reducing the frequency of use of related drugs can also prevent patients from developing drug resistance due to drug overdose, which is of great significance to reducing the medical economic burden of patients.

Objective To discuss the clinical effect of fundus laser therapy and calcium dobesilate capsules in diabetic retinopathy (DR). Methods A total of 121 DR patients (154 affected eyes) treated from December 2015 to December 2020 in Sinqi Orhthalmology Hospital and The Fourth People′s Hospital of Shenyang were selected as research objects.According to random permutation method,patients were assigned to control group (60 patients,77 affected eyes)and experimental group(61 patients,77 affected eyes). The control group took the fundus laser therapy, the experimental group took the fundus laser therapy and calcium dobesilate capsules. Visual acuity, macular thickness, blood spot area, fundus microcirculation indicators and adverse reactions were compared between the two groups. Results The visual acuity, macular thickness and blood spot area between groups showed no statistically significant differences (P＞0.05). After treatment, the visual acuity in the experimental group was higher than those in the control group, the macular thickness and blood spot area in the experimental group were smaller than those in the control group, the differences were statistically significant (P＜0.05). Before treatment, there were no significant between-group differences in the peak systolic velocity (PSV), end-diastolic velocity (EDV) and resistance index (RI) in the central retinal artery (CRA) and posterior ciliary artery (PCA) (P＞0.05). After treatment, the blood velocity in the experimental group was higher than that in the control group, RI values in the experimental group were smaller than those in the control group, the differences were statistically significant (P＜0.05). The total adverse drug reactions between groups showed no statistically significant difference (P＞0.05). Conclusion Calcium dobesilate capsules and fundus laser therapy can shrink the blood spot area, and improve the visual acuity, fundus microcirculation indicators, and treatment safety.

Objective To investigate the effect of laser photocoagulation in the treatment of fundus diseases. Methods A total of 88 patients with ocular fundus disease treated in People′s Hospital of Hechuan District from January 2019 to August 2020 were selected as the research subjects. They were divided into experimental group and control group by random number table method, with 44 cases in each group. Control group received conventional treatment, experimental group received laser photocoagulation treatment. The total effective rate, total incidence of complications, macular retinal thickness, fovea volume and recurrence rate were compared between the two groups. Results The total effective rate of experimental group was higher than that of control group, the difference was statistically significant (P<0.05). The total incidence of complications in experimental group was lower than that in control group, and the difference was statistically significant (P<0.05). Before surgery, there were no significant differences in retinal thickness and fovea volume in macular area between the two groups (P>0.05). After surgery, the macular retinal thickness and fovea volume in both groups were higher than those before surgery, and the macular retinal thickness and fovea volume in the experimental group were higher than those in the control group, with statistical significances (P<0.05). The recurrence rate of experimental group was lower than that of control group, the difference was statistically significant (P<0.05). Conclusion The total effective rate of laser photocoagulation in the treatment of fundus diseases is significantly improved, the incidence of complications and recurrence rate are significantly reduced, and the indexes of macular retinal thickness and foveal volume can be improved. It is suitable for clinical implementation and development.

 Objective To investigate the effect of Dexmedetomidine combined with Ropivacaine and Sufentanil in epidural labor analgesia. Methods From June 2018 to June 2019, 93 cases of parturient analgesia in Puning People′s Hospital of Guangdong Province were selected as the research object. They were divided into group S (n=31), group D(n=31) and group DS (n=31) according to the random number table method. Group S received epidural infusion of 0.1%Ropivacaine +0.5 μg/ml Sufentanil. In group D, 0.1% Ropivacaine +0.5 μg/ml Dexmedetomidine was injected into the epidural space. In DS group, 0.1% Ropivacaine + 0.25 μg/ml Dexmedetomidine +0.25 μg/ml Sufentanil was injected into the epidural space.The visual analogue scale (VAS)scores of pre-anesthesia and 5,10,20,30,60,90 and 120 min after anesthesia (T0-T7), each labor process, Apgar score, cesarean section rate, adverse events, onset time of anesthesia,total dose of anesthesia and amount of single load pushing (bolus) were compared. Results VAS scores of T1-T7 in the three groups were lower than those of T0, and VAS scores of group DS at T1 and T3-T7 were lower than those of group S and group D,the differences were statistically significant (P＜0.05).There were no significant differences in labor process,neonatal Apgar score and cesarean section rate among the three groups (P＞0.05). The total incidence of adverse events in group DS was lower than that in group S, the difference was statistically significant (P＜0.017). The onset time of anesthesia in group DS were shorter than those in group S and group D, the total dose of anesthesia were lower than those in group S and group D, and the bolus frequency was lower than that in group S and group D, the differences were statistically significant (P＜0.05). Conclusions Dexmedetomidine combined with Ropivacaine and Sufentanil in epidural labor analgesia can shorten the onset time and improve the analgesic effect.

Objective To investigate the clinical effect of modified Shaoyao Decoction and Yunnan Hongyao rectal on the active stage of ulcerative colitis (UC). Methods A total of 70 UC patients admitted to Fuzhou Hospital of Traditional Chinese Medicine from August 2019 to September 2021 were selected as the research objects, and they were divided into control group and study group by alternate grouping method, with 35 patients in each group. Control group was treated with conventional treatment, and research group was treated with modified Shaoyao Decoction and Yunnan Hongyao rectal dripping on the basis of control group. Both groups were treated for 4 weeks. The traditional Chinese medicine syndrome score, modified Mayo score, Baron endoscopy score, serum C-reactive protein, lactobacillus, bifidobacteria and the incidence of adverse reactions were compared between the two groups. Results After 4 weeks of treatment, traditional Chinese medicine syndrome score, modified Mayo score and Baron endoscopy score of the study group were lower than those in the control group,and the differences were statistically significant (P<0.05). After 4 weeks of treatment, the level of serum C-reactive protein in the study group was lower than that in the control group, while the counts of Lactobacillus and Bifidobacteria were higher than those in the control group, and the differences were statistically significant (P<0.05). There were no obvious adverse reactions in the two groups during treatment. Conclusion Modified Shaoyao Decoction combined with Yunnan Hongyao rectal infusion can reduce the modified Mayo score,Baron endoscopy score and inflammatory factor levels in patients with active UC, improve the intestinal flora of the patients, reduce the clinical symptoms of the patients, and have good safety.

 Objective To explore the application effect of medicine and food Tiaohe Dabu Decoction on subhealth.Methods A total of 102 subhealth people admitted to the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from June 2020 to June 2021 were selected as the research subjects, and they were divided into control group and observation group according to the random number table method, with 51 cases in each group. The control group was treated with the constitution intervention program, and the observation group was treated with Tiaohe Dabu Decoction on the basis of the control group. Blood lipid, renal function, liver function and effective rate were compared between the two groups. Results Before treatment, there were no significant differences in blood lipid, renal function and liver function between the two groups (P>0.05). After treatment, total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) in the two groups were lower than those before treatment, while high density lipoprotein cholesterol (HDL-C) was higher than that before treatment, the differences were statistically significant (P<0.05). After treatment, TC, TG and LDL-C in the observation group were lower than those in the control group, while HDL-C was higher than that in the control group, the differences were statistically significant (P<0.05). After treatment,urea, uric acid (UA) and creatinine (Cr) in the two groups were lower than those before treatment, the differences were statistically significant (P<0.05). After treatment, Urea, UA and Cr in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). After treatment, alanine aminotransferase (ALT)and aspartate aminotransferase (AST) in the two groups were lower than those before treatment, and alkaline phosphatase (ALP) was higher than that before treatment,the differences were statistically significant (P<0.05).After treatment, ALT and AST in observation group were lower than those in control group, ALP was higher than that in control group, the differences were statistically significant (P＜0.05). The total effective rate of observation group(96.08%) was higher than that of control group (78.43%), and the difference was statistically significant (P＜0.05). Conclusion The treatment of subhealthy people with medicine and food Tiaohe Dabu Decoction can significantly improve renal function and liver function, improve blood lipid level, and the clinical application effect is significant.

Objective To observe and explore the clinical effect of acupuncture method of soothing the liver and regulating the spirit on post stroke depression (PSD). Methods Eighty PSD patients admitted to Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine from June 2019 to June 2021 were selected as research subjects, they were divided into treatment group and control group according to envelope random number table method,with 40 cases in each group. On the basis of symptomatic treatment of basic disease, the treatment group was treated with acupuncture method of soothing the liver and regulating the spirit, and the control group was treated with Fluoxetine Hydrochloride Capsule. After 8 weeks of intervention, the Hamilton depression scale (HAMD), daily life activity scale(ADL) results of efficiency before and after treatment were compared. Results The total effective rate of treatment of the treatment group was higher than that of control group, and the difference was statistically significant (P<0.05). Before treatment, there were no significant differences in HAMD and ADL scores between the two groups (P>0.05). The HAMD scores of two groups were lower than those before treatment, the ADL scores of two groups were higher than those before treatment,the differences were statistically significant (P<0.05).The HAMD score of the treatment group was lower than that of the control group, the ADL score of the treatment group was higher than that of the control group, the differences were statistically significant (P<0.05). Conclusion Acupuncture method of soothing the liver and regulating the spirit can effectively improve depression after stroke.

Objective To explore the therapeutic effect of acupoint massage combined with language training on language disorders after stroke. Methods A total of 100 patients with post-stroke language impairment who were treated in the First People′s Hospital of Shenyang City from January 2019 to January 2020 were selected as the research subjects.All patients were divided into the observation group and the control group by random number table method,with 50 cases each group. The patients in the control group were treated with language training for language disorder rehabilitation,and the patients in the observation group were treated with acupoint massage combined with language training for language disorder rehabilitation. The improvement of language disorder and the quality of life were compared between the two groups. Results The improvement degree of language impairment in observation group was better than that in control group, and the difference was statistically significant (P＜0.05). After treatment, the quality of life scores of the two groups were higher than those before treatment, the differences were statistically significant (P＜0.05). After treatment,the quality of life score of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion The combination of acupoint massage and language training in the treatment of poststroke patients with language disorder can significantly improve the patients′ language disorder as well as their quality of life. It has a good clinical effect and is worthy of promotion and application.

Objective To investigate the clinical effect of traditional Chinese medicine orthopedic manipulation combined with oral administration of traditional Chinese medicine in the treatment of cervical spondylosis. Methods A total of 70 patients with cervical spondylosis admitted to Beijing Fengsheng Traditional Chinese Medicine Orthopaedic Specialty Hospital and Financial Street Community Health Service Center from July 2018 to July 2020 were selected as the research subjects. They were divided into observation group and control group by random number table method, with 35 cases in each group. Patients in the control group were treated with traditional Chinese medicine orally, while patients in the observation group were treated with traditional Chinese medicine orthopedic manipulation combined with oral administration of traditional Chinese medicine. The total effective rate, quality of life score, anxiety and depression mood score were compared between the two groups. Results The total effective rate of observation group was higher than that of the control group, the difference was statistically significant (P<0.05). Before treatment, there was no statistically significant difference in quality of life score between the two groups (P>0.05). After treatment, the scores of quality of life in the two groups were higher than those before treatment, and the score of quality of life in observation group was higher than that in control group, the differences were statistically significant (P<0.05). Before treatment,there were no statistically significant differences in anxiety and depression scores between the two groups (P>0.05). After treatment, the scores of anxiety and depression in the two groups were lower than those before treatment, and the scores of depression and anxiety in observation group were lower than those in control group, the differences were statistically significant (P＜0.05). Conclusion In the clinical treatment of patients with cervical spondylosis, the implementation of traditional Chinese medicine orthopedic manipulation combined with oral administration of traditional Chinese medicine has better therapeutic effect. After its implementation, the total effective rate is higher, and it can more effectively improve the quality of life of patients. It has more advantages and is worth popularizing in clinical application.

Objective To explore the application effect of divisional nursing combined with responsibility system nursing in outpatient nursing management. Methods A retrospective analysis was performed on the clinical case data of 165 patients admitted to Outpatient Department of Putian Medical District, The 900th Hospital of Joint Logistics Support Force, between June 2018 and June 2019. According to time-sequence method, they were divided into pre-application group (86 cases) and post-application group (79 cases). The pre-application group was given routine outpatient nursing, while post-application group was given divisional nursing combined with responsibility system nursing on basis of pre-application group. The consultation time, scores of anxiety, depression and nursing satisfaction, and examination results of nursing quality control were compared between the two groups. Results The regional placement time, doctors′consultation time and waiting time for auxiliary examination in post-application group were shorter than those in preapplication group, the differences were statistically significant (P<0.05). After intervention, scores of anxiety and depression in hospital anxiety and depression scale (HADS) in post-application group were lower than those in pre-application group, the differences were statistically significant (P<0.05). In nursing satisfaction questionnaire, scores of outpatient environment, nurse image, service awareness, service attitude, nursing operation, health education and reception process in post-application group were higher than those in pre-application group, the differences were statistically significant (P<0.05). In post-application group, incidence rates of problems in level-Ⅰquality control examination, level-Ⅱquality control examination and level-Ⅲquality control examination were 10.33%, 6.50% and 3.28%, lower than those in pre-application group (19.89%, 15.97%, 15.00%), the differences were statistically significant (P<0.05). Conclusion The application effect of divisional nursing combined with responsibility system nursing is good in outpatient nursing management.

 Objective To solve the problem of nursing document writing by action research method, optimize the quality control process of nursing document, and improve the quality of nursing document writing. Methods From June 2020 to June 2021, 27 nurses in The First Heart Ward of Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University were selected as the research subjects. The action research method was used to continuously explore with nurses to influence the writing of nursing documents through three rounds of planning, action, observation and reflection. The total score of nursing document quality control and the score of temperature sheet, evaluation sheet and nursing record sheet were compared before the action study (June 2020), after the first round of action study (October 2020) and after the third round of action study (June 2021). Results After the third round of action research, the total scores and the scores of nursing documents, temperature charts, assessment sheets, and nursing record sheets were higher than those before and after the first round of action research, and the differences were statistically significant(P<0.01). Conclusion The action research method has the advantages of solving problems and promoting changes. The nursing documentation quality improved by action research, it is worthy promoting.

 Objective To explore the effect of diversified health education on the cognition and compliance of neonatal parents′ hearing screening. Methods The parents of 100 newborns born in Fuzhou maternal and child health hospital from November 2020 to November 2021 were collected as the research objects. They were divided into the control group and the observation group by random number table method, with 50 cases in each group. The control group received routine health education, and the observation group received diversified health education, and continued to observe until the re-screening was completed. The cognitive mastery, attitude and behavior, compliance and screening status of parents in the two groups were compared. Results The scores of cognition, attitude and behavior of hearing screening in the observation group were (9.15±0.38) and (5.13±0.30) points, which were higher than those in the control group (7.39±1.10) and (4.35±0.29) points, and the differences were statistically significant (P<0.05). The total compliance of hearing screening in the observation group was 94.00%, higher than 80.00% in the control group, and the difference was statistically significant (P<0.05). The initial screening rate of observation group was 96.00%, higher than that of control group 82.00%, and the difference was statistically significant (P<0.05). There was no significant difference in screening rate between the two groups (P>0.05). Conclusion Diversified health education can improve the cognition and compliance of neonatal parents′ hearing screening, which is conducive to the early detection and treatment of neonatal hearing abnormalities.

Objective To explore the application effect of health education based on WeChat platform in cervical cancer screening of women of childbearing age. Methods A total of 240 women of childbearing age who underwent cervical cancer screening in Jingdezhen First People′s Hospital from December 2019 to December 2020 were selected as the research objects. They were randomly divided into observation group and control group, with 120 cases in each group.The observation group received health education based on WeChat platform, and the control group received routine intervention. The mastery of health knowledge, psychological state and satisfaction of the two groups were compared. Results The awareness rate of health knowledge in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05). The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). The total nursing satisfaction of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion WeChat has high application value in cervical cancer screening of women of childbearing age, and can improve patients′ mastery of disease knowledge.

 Objective To explore the application effect of scene simulation teaching mode based on 3-class in nursing teaching of cardiopulmonary bypass in cardiovascular surgery. Methods A total of 60 nursing students who practiced in cardiovascular surgery in Department of Cardiovascular Surgery of Chongqing Hospital of Chinese Academy of Sciences from October 2019 to September 2021 were selected as the research objects. They were divided into two groups according to the practice time, 30 nursing students who practiced from October 2019 to September 2020 were set as the control group，using the traditional nursing teaching method, 30 nursing students who joined the practice from October 2020 to September 2021 were set as the intervention group, and on the basis of the control group, the scene simulation teaching mode based on 3-class was used. The scores of core competence (CINS), problem solving ability (PSI) and cardiopulmonary bypass nursing technology of the two groups of nursing students before and after practice were compared. Results There were no significant differences in the scores of CINS and PSI between the two groups (P>0.05) .The scores of CINS and PSI of nursing students in the intervention group were higher than those in the control group,and the assessment results of cardiopulmonary bypass nursing technology were higher than those in the control group,the differences were statistically significant (P<0.05). Conclusions The scene simulation teaching mode based on 3-class can improve the core ability, problem-solving ability and cardiopulmonary bypass nursing technology practice ability of cardiovascular surgery nursing students, which is worthy of clinical application.

Objective To explore the application value of cotton gauze masks and non-adhesive foam dressings based on Braden score in the prevention of nasal and facial pressure ulcers on non-invasive ventilator. Methods A total of 82 patients requiring non-invasive ventilator-assisted ventilation who were admitted to the First Hospital of Nanchang in Jiangxi Province from August 2019 to August 2021 were selected as research objects. They were divided into control group and observation group according to the random number table method, with 41 cases in each group. The control group used cotton gauze masks based on the Braden score, and the observation group used non-adhesive foam dressings based on the Braden score. Both groups were evaluated after using non-invasive ventilator masks for 7 d. The risk of nasal and facial pressure ulcers, the occurrence of nasal and facial pressure ulcers and the degree of comfort between the two groups were compared. Results The observation group′s risk of nasal and facial pressure ulcers and the incidence of nasal facial pressure ulcers were lower than those of the control group, and the comfort level was higher than that of the control group, the differences were statistically significant (P<0.05). Conclusion Compared with cotton gauze masks, non-sticky foam dressings is more effective in preventing nasal and facial pressure ulcers from non-invasive ventilator. It can reduce the risk of nasal and facial pressure ulcers and improve patients′ comfort. It is worthy of clinical application.

Objective To explore the application value of specialized disease integrated nursing in type 2 diabetes.Methods A total of 80 patients with type 2 diabetes admitted to the General Hospital of the First People′s Hospital of Jiujiang City from June 2019 to December 2020 were selected as the research objects, they were divided into the control group and the observation group according to random number table method, with 40 cases in each group. The control group was given routine nursing intervention, and the observation group was given routine nursing combined with integrated nursing intervention. The blood glucose index, blood lipid index, cognitive score and satisfaction were compared between the two groups. Results The fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h PBG)and glycosylated hemoglobin (HbA1c) in the observation group after intervention were lower than those in the control group, the differences were statistically significant (P<0.05). The indexes of total cholesterol (TC) and triglyceride (TG)in the observation group after intervention were lower than those in the control group, the differences were statistically significant (P<0.05). The score of disease cognition in the observation group was higher than that in the control group,the difference was statistically significant (P<0.05). The nursing satisfaction score of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion The application of specialized disease integrated nursing intervention in patients with type 2 diabetes can effectively control blood glucose,improve blood lipid level, and enhance patients′ cognition of the disease, so as to control the disease from many aspects, with significant application value. The patients received high quality nursing service and gave high evaluation.

Objective To study the application effect of early intervention nursing in open bowel placement after neonatal enterostomy. Methods A prospective study was conducted on 60 children undergoing neonatal enterostomy in Maoming Maternal and Child Health Hospital from January 2019 to January 2021, and they were divided into reference group (n=30) and observation group (n=30) according to random number table method. The children in the reference group received routine nursing after surgery, and the children in the observation group received early intervention nursing after surgery. The anal defecation time, time of starting feeding, adequate feeding time, intravenous nutrition duration, family satisfaction, postoperative growth and development and sleep time were observed and compared between the two groups. Results The time of anal defecation, the time of starting feeding, the time of adequate feeding and the duration of intravenous nutrition in the observation group were shorter than those in the reference group, and the differences were statistically significant (P<0.05). The family satisfaction of the observation group was 93.33%, higher than that of the reference group (73.33%), and the difference was statistically significant (P<0.05). The postoperative weight,body length and head circumference of the observation group were higher than those of the reference group, and the sleep time was longer than that of the reference group, with statistical significances (P<0.05). Conclusion After neonatal enterostomy, children receive early intervention care for open bowel placement after stomostomy, which can effectively shorten the recovery time after stomostomy reduction, improve their family members′ satisfaction with nursing work, and promote the growth and development of children, which is worthy of popularization and application.

Objective To explore the application effect of acceptance and commitment therapy nursing intervention in postoperative patients with cerebral hemorrhage. Methods A total of 120 postoperative patients with cerebral hemorrhage who were admitted to the Department of Neurosurgery of Dongguan Kanghua Hospital from February 2019 to November 2019 were selected as the research objects, and they were divided into control group (60 cases) and observation group (60 cases) by random number table method. The control group received routine nursing care, and the observation group received acceptance and commitment therapy nursing intervention on the basis of the control group. The general perceived self-efficacy scale (GSES) and limb function scores were compared between the two groups before and after intervention,and the compliance of functional exercise was compared between the two groups after intervention.Results After intervention, the GSES score and limb function score of the observation group were higher than those of the control group, with statistical significances (P<0.05). After intervention, the compliance of functional exercise in the observation group was better than that of the control group, with statistical significance (P<0.05). Conclusion Adopting acceptance and commitment therapy nursing intervention for postoperative patients with cerebral hemorrhage can improve patients′ self-efficacy and functional exercise compliance, and improve patients′ limb function.

Objective To explore effect of evidence-based personalized nursing combined with Glycerini and Magnesium Sulfate enema to relieve abdominal distension after cesarean section. Methods A total of 60 cases of cesarean section women admitted to Ruijin Maternity and Child Health Hospital from January 2020 to July 2021 were selected as the research subjects. They were divided into control group and experimental group according to random number table method, with 30 cases in each group. The control group was given routine nursing after delivery, and the experimental group was given personalized nursing based on evidence-based concept, combined with Glycerini and Magnesium Sulfate enema nursing intervention after delivery. The recovery after cesarean section, self-rating anxiety Scale(SAS), self-rating depression scale (SDS) scores and complications were compared between the two groups. Results The first time of anal exhaust, recovery time of spontaneous defecation, relief time of abdominal distention and hospital stay in the experimental group were shorter than those in the control group after cesarean section, and fecal volume was more than that in the control group, the differences were statistically significant (P<0.05). After nursing, the score of SAS and SDS in experimental group were lower than those in control group, the differences were statistically significant(P<0.05). There was no significant difference in the total incidence of complications after cesarean section between the two groups (P>0.05). Conclusion Evidence-based personalized nursing combined with Glycerini and Magnesium Sulfate enema can improve abdominal distension after cesarean section.

Objective To explore the application value of breastfeeding chair in mother and child co-room ward.Methods A total of 400 pregnant women eligible for breastfeeding in the People′s Hospital of Xiangdong District in Pingxiang City from January 2019 to January 2020 were selected, according to the random number table method, they were divided into the control group and the observation group, with 200 cases in each group. The control group was fed with traditional methods, and the observation group was fed with breastfeeding chair under the guidance of responsible nurses. The start lactation time, the start breastfeeding time, milk secretion, the success rate of pure breastfeeding,breastfeeding comfort and the incidence of nipple chapped were compared between the two groups. Results The starting lactation time and the breast feeding time of the observation group were (23.59±8.41) hours and (57.86±5.47) min respectively, which were shorter than those of the control group of (39.26±9.74) hours and (102.45±25.23) min, the amount of milk secretion of the observation group was more than that of the control group, and the differences were statistically significant (P＜0.05). The success rate of pure breastfeeding in the observation group (95.50%) was higher than that in the control group (73.50%), and the difference was statistically significant (P＜0.05). The breastfeeding comfort of the observation group (94.50%) was higher than that of the control group (81.00%), and the difference was statistically significant (P＜0.05). The incidence of nipple chapped in the observation group (3.00%) was lower than that in the control group (14.50%), and the difference was statistically significant (P＜0.05). Conclusion The application of breastfeeding chair in in mother and child co-room ward can reduce all kinds of discomfort during breastfeeding, promote breast milk secretion, effectively improve the success rate of breastfeeding and ensure the health of mothers and child.

 Objective To explore the application effect of nourishing touch with parental involvement on premature infants. Methods A total of 100 premature infants admitted to neonatal intensive care unit (NICU) of Yichun Maternal and Child Health Care Hospital from October 2019 to June 2020 were selected as the study subjects, and they were divided into the nourishing touch group (n=50) and the routine group (n=50) according to the lottery (paper sticks with numbers 1-100 were made, according to the odevity of the numbers drawn). The routine group was given routine developmental support intervention, and the nourishing touch group was given nourishing touch with parental involvement for intervention. The body weight change, neonatal behavioral neurological assessment (NBNA), the occurrence of adverse reactions, daily sleep time, hospital stay and family satisfaction were compared between the two groups. Results The body weights of the two groups at 3 weeks of intervention were heavier than those before intervention, the differences were statistically significant (P＜0.05). The body weight in the nourishing touch group at 3 weeks of intervention was heavier than that in the routine group, the difference was statistically significant (P＜0.05).The NBNA scores at 1, 2 and 3 weeks of intervention in the two groups were higher than those before intervention, the differences were statistically significant (P＜0.05). The NBNA scores in the nourishing touch group at 1, 2 and 3 weeks of intervention were higher than those in the routine group, the differences were statistically significant (P＜0.05). The total incidence rate of adverse reactions at 3 weeks of intervention in the nourishing touch group was lower than that in the routine group, the difference was statistically significant (P＜0.05). The daily sleep time in the nourishing touch group was longer than that in the routine group, while the hospital stay in the nourishing touch group was shorter than that in the routine group, and the measure of processes of care (MPOC-20) score in the nourishing touch group was higher than that in the routine group, the differences were statistically significant (P＜0.05). Conclusion Nourishing touch with parental involvement can speed up the growth and development of premature infants, reduce the incidence rates of adverse reactions and improve the family satisfaction.

Objective To explore the effect of oral Chinese medicine combined with Dazhui acupoint bloodletting cupping nursing in leukemia patients with cancer fever. Methods A total of 70 patients with leukemia and fever admitted to Hongqi Hospital Affiliated to Mudanjiang Medical College from January 2019 to December 2020 were selected as the research subjects, and they were divided into control group (35 cases) and observation group (35 cases) by random number table method. The control group was treated with conventional cooling method, and the observation group was treated with oral Chinese medicine combined with bloodletting and cupping at Dazhui point. The score of fever symptom,rehabilitation effect of fever and nursing satisfaction of patients were compared between the two groups. Results The score of fever symptom in observation group after nursing was (2.49±0.39) points, lower than that in control group(3.19±0.61) points, the difference was statistically significant (P＜0.05). The total effective rate of the observation group was 97.14%, higher than that of the control group (82.86%), and the difference was statistically significant (P＜0.05).The total nursing satisfaction of the observation group was 97.14%, higher than that of the control group 80.00%, the difference was statistically significant (P＜0.05). Conclusion The method of nursing intervention of traditional Chinese medicine can control the symptoms of cancer fever in leukemia patients, and the effect is relatively ideal.

Objective To explore the effect of high-quality nursing for patients with cerebral hemorrhage on their cognitive function and prognosis. Methods A total of 107 patients undergoing intracerebral hemorrhage surgery in the Second Affiliated Hospital of Xiamen Medical College from June 2017 to June 2020 were selected as the research subjects, and they were divided into control group (53 cases) and study group (54 cases) by random number table method.Patients in the control group took routine nursing, patients in the study group carried out high-quality nursing. The cognitive function and neurological function defects of the two groups were compared before and after intervention. The total incidence of complications was compared between the two groups. The quality of life before and after intervention was compared between the two groups. Results After intervention, the mini-mental state examination (MMSE) score of patients in the study group was higher than that in the control group, the score of National Institutes of Health stroke scale (NIHSS) was lower than that of control group, and the differences were statistically significant (P<0.05). The total incidence of postoperative complications in study group (3.7%) was lower than that in control group (15.1%), and the difference was statistically significant (P<0.05). After intervention, short form 36-item health survey scores and total score of patients in the study group were higher than those in the control group, with statistically significant differences(P<0.05). Conclusion The effect of high-quality nursing for patients after cerebral hemorrhage is significant, which can improve their clinical symptoms and reduce the incidence of postoperative complications. It is recommended to be widely used.

Objective To observe the application effect of ball grip exercise combined with Kanghuier transparent paste in the prevention of complications of lung cancer patients undergoing peripherally inserted central catheter (PICC)chemotherapy. Methods From December 2019 to January 2021, 96 patients with lung cancer undergoing PICC intubation chemotherapy from the Department of Respiratory Medicine, Jiujiang First People′s Hospital were selected as the research objects, and they were divided into the control group and the study group by random number table method,woth 48 cases in each group. The control group was treated with 50% magnesium sulfate warm compress, and the study group was treated with hydrocolloid dressing Kanghuier transparent paste combined with ball grip training intervention.The maximum blood flow rate (Vmax) and mean blood flow rate per unit time (TMFV) of axillary vein side of limbs were compared before and 1, 2 and 3 months after catheterization between the two groups. Results The incidence of phlebitis and venous thrombosis in the study group were lower than those in the control group after intervention, and the differences were statistically significant (P<0.05). There was no significant difference in the incidence of bleeding and catheter ectopic between the two groups (P>0.05). There were no significant differences in Vmax and TMFV levels before catheterization between the two groups (P>0.05). Vmax and TMFV levels in 1, 2 and 3 months after catheterization were lower than those before catheterization, the differences were statistically significant (P<0.05). The Vmax and TMFV levels of patients in the study group were higher than those in the control group at 1, 2 and 3 months after catheterization, the differences were statistically significant (P<0.05). There were statistically significant differences in groups and interactions (P<0.05). Conclusion Holding the ball and Kanghuier transparent paste can effectively reduce the occurrence of complications in patients with lung cancer patients undergoing PICC intubation chemotherapy, and it is worthy of clinical application.