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Quick Search     Adv Search 2016 Vol. 23, No. 26 Published: 2016-09-18   4 Construction of human umbilical cord mesenchymal stem cell lines to secret stable human HSP72 with Lenti-viral Vector WANG Zhen；ZHAO Chang-lin；LUOMin-xiang Objective To construct Lenti-viral Vector carrying human HSP72 gene，and to screen the hUC-MSC cell line with stable expression of HSP72.Methods The human HSP72 cDNA was amplified from"MGC fully sequenced human HSPAIA cDNA"by PCR.pLV-HSP72-EGFP（2A）plasmid was obtained by double enzyme digestion and in vitro recombination，then was confirmed by PCR and DNA sequencing.The pLV-HSP72-EGFP　（2A）virus was packaged. hUC-MSC was infected by the virus，and the hUC-MSC cell lines stably expressing HSP72 were screened by Puro. Results The recombinant pLV-HSP72-EGFP　（2A）was constructed.The sequence was consistentwith that reported in GenBank.The pLV-HSP72-EGFP（2A）viruswas packaged and infected hUC-MSC.By ELISA，itwas confirmed that the HSP72 protein could be expressed and secreted into the supernatant of hUC-MSC strain culture.Conclusion hUC-MSC cell linewith stable expression of HSP72 is constructed. 2016 Vol. 23 (26): 4-8 [Abstract] ( 165 ) HTML (39 KB)  PDF  (0 KB)  ( 12 ) 9 Psoralen on ovariectom ized rat dementia in hippocampus of rats brain tissue pathological effect PAN Yong-mei；WANG Jian-hua；FANG Jing；WANG Rui Objective To investigate the effects of psoralen on ovariectomized rat dementia in hippocampus of rat brain tissue pathological effect.Methods From February 2013 to January 2016，the preparation of ovariectomized dementia rat model were divided the sham operation group，model group and psoraleae group，with 10 rats in each group，included psoralen group model after intragastric administration 29 d，model group were given routine saline instead. The pathological changes of the hippocampus of rats in each group were observed and compared.Results Compared with the sham group，rats in themodel group，the latency were significantly prolonged（P＜0.05）；compared with the model group，psoralen group were markedly shorted the incubation period　（P＜0.05）；and at the same time the psoralen group rats across the platform number were increased significantly，and compared the model group were significant difference（P＜0.05）.The SOD contents in the sham group，model group，psoraleae group were（145.30±18.42），（110.49± 6.46）and　（120.98±7.13）U/gprot，the content of MDA were　（2.87±0.44），（4.46±0.63）and（3.19±0.42）nmol/mgprot. Compared with the sham group，SOD content of the model group were significantly decreased，MDA content were increased significantly；and the contents of SOD and MDA in the psoralen group compared to the other groups difference were statistical significance　（P＜0.05）.Ultrastructural TEM showed that themorphology of pyramidal cells of psoralen group improved，uniform，neatly arranged，clear structure.Conclusion Psoralen in dementia rat ovarian application can improve the SOD enzyme activity，reduce MDA content，thus benefit the brain hippocampus pathological improvement，improvememory ability. 2016 Vol. 23 (26): 9-11 [Abstract] ( 170 ) HTML (34 KB)  PDF  (0 KB)  ( 33 ) 12 New progress in treatment of secretory otitismedia LIU Guang-hua Pathogenesis of secretory otitismedia is not clear，poor eustachian tube function and infection theory are the main causes of disease，the treatments of secretory otitismedia have no definite solution，there are drugs and surgery，drug therapy include antibiotics，corticosteroids and surface-active substances etc.，commonly used surgical treatment methods have tympanicmembrane puncture，myringotomy with grommet insertion，tympanostomy etc.，in recent years，popular eustachian tube balloon and video laryngoscope or endoscopic injection in eustachian also have made a better clinical outcome.Tomaintain the pressure balance inside and outside themiddle ear，that eustachian tube restored normal physiological function is the key to its treatment.Investigative BCG vaccine，cell factor antagonists by using the modern science and technology in the prevention and treatment of secretory otitismedia are the direction of further research in the future. 2016 Vol. 23 (26): 12-14转18 [Abstract] ( 170 ) HTML (42 KB)  PDF  (0 KB)  ( 32 ) 15 Research progress on the relationship between chronic calculus cholecystitis and gallbladder carcinoma ZOU Rong-ji；MA Qing-jiu Gallbladder carcinoma is themost common malignant tumor in biliary system.Themain risk factors are due to prolonged exposure to gallbladder stones.Under the chronic inflammatory environment enabled by the recurrent cycles of gallbladder epithelium damage-repair，which promotesmorphological impairment of gallbladder epithelial cells through the process of"metaplasia and dysplasia and cancer".In this paper，the relationship between chronic calculus cholecystitis and gallbladder carcinoma is reviewed，which provides the research basis for the prevention，early diagnosis and drug treatment of gallbladder carcinoma. 2016 Vol. 23 (26): 15-18 [Abstract] ( 190 ) HTML (37 KB)  PDF  (0 KB)  ( 19 ) 19 Clinical experience of surgical treatment of 100 cases of senile gallstones YE Rong-qiang；　XIE Yuan-cai；　ZHONG Ding-wen Objective To explore the method and effect of the treatment of senile patients with gallstones.Methods Sources of information in our hospital from February 2013 to September 2015，100 cases of cholelithiasis were treated，according to the different surgicalmethods，divided into endoscopic surgery group and conventional surgery group.Conventional surgery group was used traditional gallbladder resection surgery treatment；endoscopic surgery group was used laparoscopic gallbladder resection surgery treatment.In the two groups of patients with cholecystectomy operation time，bleeding volume，postoperative anal exhaust time，hospital days and the cure rate，the incidence of complications，postoperative quality of life were compared.Results The cure rate of laparoscopic surgery group was similar to conventional surgery group（P＞0.05），complication rate of laparoscopic surgery group was lower than that of conventional surgery group （P＜0.01）.Laparoscopic surgery group patients with cholecystectomy with conventional surgery group had no significant difference（P＞0.05）.Laparoscopic surgery group of intraoperative bleeding，postoperative anal exhaust time，hospitalization time were less than those of conventional surgery group（P＜0.01）.The quality was superior to conventional laparoscopic surgery group survival surgery group（P＜0.05）.Conclusion Cholelithiasis by laparoscopic surgery for treatment，can effectively reduce the surgical trauma，reduce the intraoperative bleeding and postoperative complications after，accelerate postoperative anal exhaust，shorten the hospitalization time，improve the quality of life in patientswith postoperative，worthy of promotion. 2016 Vol. 23 (26): 19-21 [Abstract] ( 170 ) HTML (34 KB)  PDF  (0 KB)  ( 32 ) 22 Analysis of different surgical procedures on the prognosis of patientswith acute appendicitis QIU Han-yu ；CHEN Guo-qiang； GONG Hao Objective To explore the effect of different surgicalmethods on the prognosis of patients with acute appendicitis.Methods Retrospective analysis of 60 cases of acute appendicitis in our hospital from January 2014 to January 2015 were divided into two groups according to the operation method of the patients，1 group and 2 group.1 group was taken to open surgerymeasures；the 2 group was taken themeasures of laparoscopic surgery.The operation time，average blood loss，postoperative recovery of exhaust and feeding time，bed time，length of stay，and analgesic use rate，and the incidence of adverse symptoms of the two groups were compared.Results The rate of use of analgesic drugs in 2 group，the incidence of adverse symptoms was lower than that of 1 group（P＜0.01）.Operation time，average blood loss，postoperative recovery of exhaust and feeding time，bed time and hospital stay in the 2 group were all less than that of 1 group（P＜0.01）.Conclusion There are differences in prognostic impact of different surgicalmethods for acute appendicitis patients.Among them，laparoscopic surgery is superior to laparotomy，reflecting in theminimally invasive，easy to operate，low trauma and postoperative rapid recovery characteristics，can effectively reduce the complications and analgesic drug use and isworthy to be popularized. 2016 Vol. 23 (26): 22-24 [Abstract] ( 172 ) HTML (32 KB)  PDF  (0 KB)  ( 28 ) 25 Prelim inary study on the method and effect of emergency treatment of severe asthma with respiratory failure ZHANG Hong-lin Objective To explore the emergency treatmentof severe asthmawith respiratory failure and itseffect.Methods From January 2012 to December 2015，100 cases of patientswith severe asthma and respiratory failure were selected as the subjects of this study.The patientswere randomly divided into the control group and the observation group by taking the digital random tablemethod，50 cases in each group.The control group was given routine treatment，the observation group was treated with noninvasive positive pressure ventilation at the same time.The carbon dioxide partial pressure （PaCO2），oxygen partial pressure（PaO2），pH value，respiratory rate（RR）before and after treatmentwere compared between two groups，and the time of hospital stay and death were compared between two groups.Results After treatment，PaCO2and RR in two groupswere significantly decreased　（P＜0.05），PaO2，pH value in two groupswere significantly increased （P＜0.05），and the indexes were compared between two groups，with the statisticant differences（P＜0.05）.Compared with the control group，the time of hospital stay in the observation group was significantly shorter（P＜0.05）.There were no deaths in the observation group，the rate of death in the control group was 4%，the difference was not statistically significant（P＞0.05）.Conclusion In the emergency treatment of patientswith severe asthma and respiratory failure，the implementation of noninvasive positive pressure ventilation can effectively improve the patient′s blood oxygen condition，correct the hypoxia and acidosis state，it is help to reduce the patient′smortality. 2016 Vol. 23 (26): 25-27 [Abstract] ( 192 ) HTML (34 KB)  PDF  (0 KB)  ( 36 ) 28 The app lication of PiCCO in intensivemedical WANG Fei ；LIGuan-yin　；HOU Yong-gang Objective To explore the effect of pulse inducator continous cadiac output（PiCCO）technology in the application of intensive care unit（ICU）.Methods 21 patients ofmultiple traumatic from October 2014 to June 2015 in ICU were selected and used PiCCOmonitoring technology to guid resuscitation.The change of the capacity index of PiCCO before and after resuscitation（6 hours and 12 hours）were recorded.The capacity index∶stroke volume variation（SVV），extravascular lung water index（EVLWI），intrathoracis blood volume index（ITBVI），global end diastolic volume index（GEDVI）.Observe the change of heart rate（HR），mean arterial pressure（MAP），central venous pressure（CVP），cardiac index （CI），and after that an analyzation by using statisticswas given.Results Compared with the score of MAP，CITBVI，GEDVI and CVP before resuscitation increased significantly after resuscitation（P＜0.05）.Compared with the score of SVV before resuscitation decreased significantly after resuscitation（P＜0.05）.The score of EVLWIbefore resuscitation increased，However，there was no obvious difference（P＞0.05）.Conclusion Accoding the PiCCOmonitoring index to guide treatment and cure shock has satisfactory effect in short term.PiCCO technology is the most secure and reliable，and should be the one ofmost needed instrument in ICU. 2016 Vol. 23 (26): 28-30 [Abstract] ( 161 ) HTML (35 KB)  PDF  (0 KB)  ( 35 ) 31 Study the correlation of disease control and patients with bronchial asthma treatment adherence XIE Xian-mao Objective To explore the relationship between treatment compliance and disease control in patients with bronchial asthma.Methods 120 patientswith adult bronchial asthma from April 2013 to April 2015 in our hospitalwere treated and selected as the object，medication compliance questionnaire，the most recent remission period（LRP），adult asthma quality of life score（AQLQ），asthma control test（ACT）grade etc，the treatment compliance of the patients and its correlation with disease control statuswere analyzed.Results 76 patients（63.3%）with good compliance of drug therapy；44 patients（36.7%）with poor compliance of drug treatment.In patients with good compliance，the number of complete control of the disease was significantly higher than that of the patients with poor treatment compliance.The treatment compliance of the patients was positively correlated with the scores of quality of life of the patients.LRP of patientswith poor treatment compliancewas（2.3±0.5）months，the treatment compliance of patientswith LRPwas（8.2±1.0）months，with the significant difference　（P＜0.05）.Conclusion Good treatment compliance in patientswith bronchial asthma is helpful for disease control，can better improve the quality of life of patients，improve the overall treatment effect. 2016 Vol. 23 (26): 31-33 [Abstract] ( 171 ) HTML (34 KB)  PDF  (0 KB)  ( 33 ) 34 Clinical study on the distribution of pathogenic bacteria and the correlation of incision infection after appendicitis operation YAN Yun-xi； LUO Fang；　YIN Ying-bin Objective To investigate the pathogenic bacteria distribution and correlation of incision infection after appendicitis operation.Methods From March 2014 to March 2016 100 patients with underwent open appendectomy were randomly selected in our hospital departmentof general surgery，the incision infection，and implement the appendix cavity secretion culture，postoperative infection of incisionalwound secretion culture and drug sensitive testwere observed. Results In 100 patients，postoperative emergence of incision infection were 12 cases（12.0%）；88 cases of incision uninfected patients with appendicitis secretions sent for culture and drug sensitivity were 25 cases，showing 20 cases were positive，a total separation of 28 isolates，Escherichia coli accounted for the highest proportion；12 cases of incisional infection implementation wound secretions for bacterial culture，showing were positive，16 strains，Escherichia coli accounted for the highest proportion.Conclusion Escherichia coli is themain pathogenic bacteria of incision infection after appendectomy，the highest resistance to antibiotics such as ampicillin penicillin；appendicitis postoperative incision infection pathogens is connected with appendicitis pathogen. 2016 Vol. 23 (26): 34-36 [Abstract] ( 166 ) HTML (32 KB)  PDF  (0 KB)  ( 39 ) 37 Clinical research on treatment of Aidi combined with TACE interventional therapy for primary hepatic carcinoma GUOMeng-an；XU Mei-hua；　HU Qi-jun Objective To explore the clinic value of Aidi combined with TACE interventional therapy for primary hepatic carcinoma　（PHC），in order to provide a safe and effective treatmentmodel.Methods 71 caseswith PHC hospitalized in the hospital from January 2012 to October 2015 were randomly divided into two group，Patients treated by Aidi combined with TACE interventional therapy were selected as research group（n=36）and TACE interventional therapy alone as control group　（n=35）.The clinic effects and adverse reactions and so on between two groupswere compared.Results The difference had statistical significance in effect rate（research group of 77.78%，control group of 48.57%），AFP and survival rate between two groups（P＜0.05）.Conclusion The combined therapy of Aidi and TACE for patientswith PHC is prior to alone TACE interventional therapy in effect，karnofsky performance status，AFP and adverse reactions and so on，which isworthy of popularization and application in clinic． 2016 Vol. 23 (26): 37-39 [Abstract] ( 195 ) HTML (35 KB)  PDF  (0 KB)  ( 29 ) 40 Application significance of HPV detection and TCT　exam ination in screening of cervical cancer WANGWu Objective To explore the significance of high risk human papillomavirus（HPV）detection and thinprep cytology test（TCT）examination in cervical cancer screening.Methods From January 2013 to December 2015，120 patients suspected cervical cancer were selected as study object，all patients underwent HPV test，TCT and the pathology results as"gold standard".Sensitivity，specificity，accuracy of HPV，TCT in cervical cancer diagnostic were calculated and the diagnosis results of two groups were compared.According to the degree of cervical lesions patients were grouped into CINⅠ，CINⅡ，CINⅢ，cervical cancer，cervical lesions of different HPV viral load were compared.Results Sensitivity，specificity and accuracy of HPV in cervical cancer diagnostic was 96.00%and 73.33%，87.50%respectively，with 84.00%，91.11%and 86.67%respectively of TCT，the sensitivity of HPV was significantly higher than that of TCT　（P＜0.05），but the specificity of TCT was significantly higher than that of HPV　（P＜0.05），the accuracy of twomethods was considerable（P＞0.05）.HPV viral load in patientswith different degree of cervical lesionswere compared，and the difference was statistically significant（P＜0.05）.Conclusion In the screening of cervical cancer，HPV has high sensitivity，TCT has high specificity，two kinds of inspectionmethods can be combined to reduce themissed diagnosis andmisdiagnosis. 2016 Vol. 23 (26): 40-42 [Abstract] ( 163 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 43 The app lication value of tumormarkers HE4 and CA125 in ovarian tumor LI Feng；HE Hua；ZHU Ya-fei；JIANG Li-xia；WANG Qin Objective To establish a simple and effectivemethod of predicting ovarianmalignant tumor by the detection of serum human epididymis protein 4　（HE4）and carbohydrate antigen 125　（CA125）of patients with ovarian tumor. Methods Serum HE4 and CA125 levels of 453 patients with ovarian tumor in our hospital from January 2013 to December 2014 were determined by Roche electrochemical luminescence method.Among them，80 patients with ovarian malignant tumor，373 patientswith ovarian benign tumors（including 135 cases of ovarian endometriosis cyst，116 cases of ovarian teratoma，45 cases ofmucous and serous cystadenoma，51 cases of ovarian simple cyst and 26 cases of corpus luteum cyst）.All the results were statistically analysed.Results Comparison of serum HE4 levels between patients with ovarian benign tumor，there was no statistically significant difference　（P＞0.05）；serum CA125 level of ovarian endometriosis cyst group was higher than that of other groups，the differencewas statistically significant（P＜0.05），Comparison between the rest of the group，there was no statistically significant difference　（P＞0.05）.If compared with benign ovarian tumors，serum HE4 cut-off value was 126.2 pmol/L，the clinical diagnosis sensitivity in patients with ovarian malignant tumorwas 72.5%.Conclusion HE4 and CA125 are better clinical auxiliary diagnosis indicator of ovarian tumor. 2016 Vol. 23 (26): 43-45 [Abstract] ( 144 ) HTML (31 KB)  PDF  (0 KB)  ( 46 ) 46 The clinical value of Erlotinib first-line treatment for elderly patients with non-small cell lung cancer with chronic obstructive pulmonary disease ZENG Zhao-dun Objective To study the clinical value of Erlotinib first-line treatment for elderly patients with non-small cell lung cancer with chronic obstructive pulmonary disease　（COPD）.Methods 80 cases of elderly patients with nonsmall cell lung cancer patientswith COPD from January 2012 to March 2013 were selected and randomly divided into Erlotinib group and chemotherapy group，patients were treated by Erlotinib first-line treatment and chemotherapy respectively.The efficacy and toxic and side effect of treatment between two groupswere compared，and patientswere followed up，the lifetime of patients between two groups were searched.Results The effective rate of the Erlotinib group was significantly higher than that of the chemotherapy group（χ2=4.2667，P=0.0389），the control rate was also significantly higher than that of the chemotherapy group　（χ2=4.7127，P=0.0299）.The incidence ofmyelosuppression and gastrointestinal reaction in the Erlotinib group were significantly lower than those in the chemotherapy group　（χ12=20.3135，P= 0.0000；χ22=4.0525，P=0.0441）；the incidence of rash between two groups was significant difference　（χ2=13.0909，P= 0.0003）.Progression-free survival（PFS）and overall survival（OS）in the Erlotinib group were significantly longer than those in the chemotherapy group，the difference was statistically significant（t1=3.2579，P=0.0017；t2=6.3139，P=0.0000）. Conclusion Erlotinib first-line treatment for elderly patientswith non-small cell lung cancer with COPD has good effect，whih can significantly improve the treatmentefficiency，reduce the incidence of toxic and side effect，prolong lifetime of patients. 2016 Vol. 23 (26): 46-48 [Abstract] ( 186 ) HTML (33 KB)  PDF  (0 KB)  ( 32 ) 49 Clinical research of different radiotherapy fractionated methods of preoperative concurrent radiotherapy and chemotherapy for rectal cancer LIU Xiao-mei ；DENG Ze-feng Objective To explore the clinical effects of different radiotherapy fractionated methods of preoperative concurrent radiotherapy and chemotherapy for rectal cancer.Methods 60 patients with middle and lowⅡ-Ⅲstage rectal cancer in our hospital from June 2015 to August 2016 were selected as study objects and divided into observation group and control group by random number table，with 30 cases in each group.Patients in the observation group were used modified short course radiotherapy and chemotherapy，and patients in the control group were used conventional fractionated radiotherapy and chemotherapy.General information of rectum segmentation and sigmoid loop colostomy，tumor drop period rates and adverse effects of patients in two groupswere compared.Results The drop period rate in the observation group was 30.00%　（9/30），lower than 68.00%　（20/30）in the control group　（P＜0.05）；total incidence rate of toxic and side effect and adverse reaction in the observation group was 30.00%（9/30），lower than 50.00%　（15/30）in the control group，the difference between two groupswas not statistically significant（P＞0.05）.Conclusion Both of preoperative concurrent chemotherapy modified short course and fractionated chemotherapy are suitable for rectal cancer patients.Differentways of radiotherapy are used according to different patients，which can reduce the incidence of local recurrence and enhance effects. 2016 Vol. 23 (26): 49-51 [Abstract] ( 168 ) HTML (33 KB)  PDF  (0 KB)  ( 30 ) 52 Effect observation of Cisplatin and Docetaxel in the treatment of patients with non small cell lung cancer KUANG Shu-gen；　LIU Xia ；LIU Tie-bing　；ZHANG Shi ；WENQin-sheng Objective To analyze effect of Cisplatin combined with Docetaxel in the treatment of non small cell lung cancer.Methods 42 patients with non small cell lung cancer treated in our hospital from January 2015 to June 2016 were selected as study group，and 42 patients with non small cell lung cancer from February to December in 2014 as control group.Patients in the control group were given combined treatment of Gemcitabine and Cisplatin，patients in the study group were treated by Docetaxel and Cisplatin，clinical efficacy，toxic and side effect，average disease progress time and average survival time in two groupswere observed and compared.Results After treatment，total efficiency rate in the study group was 85.71%，higher than 66.67%in the control group　（P＜0.05）；occurrence rate of toxic and side effect in the study group had no significant difference compared with the control group　（P＞0.05）；average disease progress time and average survival time in the study group were better than those in the control group　（P＜0.05）.Conclusion Combined treatment of Gemcitabine and Cisplatin in patients with non small cell lung cancer hasmore significant therapeutic effect and high safety，which can be extended in clinic. 2016 Vol. 23 (26): 52-53转57 [Abstract] ( 156 ) HTML (30 KB)  PDF  (0 KB)  ( 34 ) 54 Application of the critical neonatal transport system in Huaian City GAO Zi-bo　；PAN Zhao-jun　；ZHAO Yu-xiang；　HAN Liang-rong；　JIDong-lin；　LIU Juan　；WU Rong Objective To evaluate the operation effects of the neonatal emergency transport system（NETS）for critically ill newborns of Huaian City as well as its clinical significance in the cure of critically ill newborns and to explore its drawbacks.Methods The clinical data of the newbornswho were transported to Maternity and Child Health Care Hospital of Huaian City through the NETS from January 2011 to December 2015 were analyzed.The proportion of disease constitution，the success rates of transportation，total cure rate and mortality of the transported critically ill newbornswas calculated.Results Over the past 5 years，a total of 846 cases of ill newbornswere transported and the first three ones of the disease categories　（first diagnosis）of the transported newborns were respectively∶367 cases　（43.38%）of neonatal pneumonia and respiratory failures，146 cases　（17.26%）of neonatal sepsis and purulent meningitis，and 135 cases （15.96%）of asphyxia of newborn，hypoxic ischemic encephalopathy and intracranial bleeding.Suchmedical treatments as keeping warm，monitoring，infusion as well as oxygen supply and blood glucosemonitoring were widely used during the transportation process.A total of 268 cases underwent transportation ofmechanical ventilation，accounting for 31.68%of the total number of transported newborns，and it rose gradually annually and the differences featured statistical significance　（P＜0.01）.Therewere a total of 23 cases of newbornswho failed to be transported successfully at one time，among which 11 cases were subject to secondary transport after their conditions had been stabilized and were successfully transported to the ICU wards.There was no a single death on the way of transportation，there were a total of 6 cases whose conditions deteriorated after being transported to the NICU and died within 2 hours，accounting for 0.71%of the total number of transports，and themain cause of death was severe septic shock，multiple organ failures caused by severe asphyxia and pulmonary hemorrhage.Conclusion The active implementation and constant perfection of NETS features have important significance to the elevation of the quality of life of the ill patients and the reduction of the death rates of the neonatal diseases. 2016 Vol. 23 (26): 54-57 [Abstract] ( 173 ) HTML (40 KB)  PDF  (0 KB)  ( 35 ) 58 Therapeutic effect of Levonorgestrel-releasing intrauterine system and com pound oral contraceptive in the treatment of patients with ovarian endometriosis recurrence ZHANGMing-fang ；DAIHong-chun Objective To explore the application effect of Levonorgestrel-releasing intrauterine system　（LNG-IUS）and compound oral contraceptive（COC）in the treatment of patientswith ovarian endometriosis recurrence.Methods 86 patientswith ovarian endometriosis recurrence in our hospital from April 2012 to June 2016 were selected and divided into the research group and the control group according to random number tablemethod，43 cases in each group.The control group was given COC therapy，the research group was given LNG-IUS treatment.The therapeutic effect in the two groupswas compared.Results The volume of ectopic cyst of ovary and the level of serum CA125 after treatment in the research group was less than that in the control group，with significant difference　（P＜0.01）.The VASscore of dysmenorrhea and chronic pelvic pain after treatment in the research group was lower than that in the control group，with significant difference（P＜0.01）.The total effective rate in the research group was 93.02%，which was higher than 74.42%in the control group，with significant difference（P＜0.05）.Conclusion The application value of LNG-IUS in the treatment of ovarian endometriosis recurrence is better than that of COC，it isworthy of clinical promotion and application. 2016 Vol. 23 (26): 58-60 [Abstract] ( 168 ) HTML (34 KB)  PDF  (0 KB)  ( 39 ) 61 Discussion of conservative treatmentmethod of tubal pregnancy LIU Ai-min；　CHEN Feng Objective To explore the conservative treatmentmethod of tubal pregnancy.Methods 90 patients with unruptured and no abortion tubal pregnancy from January 2006 to December 2014 in our hospitalwere selected and randomly divided into the experimental group，the laparoscopic surgery group and the drug conservative treatment group，30 cases in each group.The experimental group was treated with gestational sac puncture and injection ofmedicinemethod combined with oral traditional Chinesemedicine，the laparoscopic surgery group was treated with laparoscopic surgery，the drug conservative treatment group was treated with drug conservative treatment.The cure rate，the time ofβ-HCG decreased to the normal，the disappearance time of ectopic mass，the tubal patency rate of the affected side，the cost of treatment among three groups was compared respectively.Results The cure rates of the three groups were 100%，100% and 90%in the experimental group，the laparoscopic surgery group and the drug conservative treatment group.The time ofβ-HCG decreased to the normal in the experimental group and the laparoscopic surgery group was shorter than that in the drug conservative treatment group，with significant difference　（P＜0.05）.There was no significant difference in the time ofβ-HCG decreased to the normal between the experimental group and the laparoscopic surgery group　（P＞0.05）. The disappearance time of ectopic mass in the laparoscopic surgery group was shorter than that in the experimental group and the drug conservative treatmentgroup，with significant difference　（P＜0.05）.The disappearance time of ectopic mass in the experimental group was shorter than that in the drug conservative treatment group，with significant difference　（P＜0.05）.The tubal patency rate of the affected side in the experimental group was higher than that in the laparoscopic surgery group and the drug conservative treatment group，with significant difference　（P＜0.05）.There was no significant difference in the tubal patency rate of the affected side between the laparoscopic surgery group and the drug conservative treatment group　（P＞0.05）.The cost of treatment in the laparoscopic surgery group was higher than that in the experimental group and the drug conservative treatment group，with significant difference（P＜0.05）.There was no significant difference in the cost of treatment between the laparoscopic surgery group and the drug conservative treatmentgroup（P＞0.05）.Conclusion The effectof killing embryo of gestational sac aspiration injection ofmedicinemethod combined with oral traditional Chinesemedicine in the treatmentof unruptured and not abortion tubal pregnancy patients is obvious，which can significantly shorten themass disappearance time，improve the tubal patency rate of the affected side，and the treatment cost is low，it is of great significance to the patients with fertility requirement of unruptured and no abortion tubal pregnancy. 2016 Vol. 23 (26): 61-63 [Abstract] ( 140 ) HTML (37 KB)  PDF  (0 KB)  ( 38 ) 64 Clinical observation of the trans-abdom inal adenom yomectom y combined with uterine artery blockage in the treatment of 76 patients with uterine adenom yosis LILi-jing；QIU Yang；HUANGMing-jun Objective To compare the effect between trans-abdominal adenomyomectomy and trans-abdominal adenomyomectomy combined with uterine artery blockage（UAB）in the treatment of patientswith uterine adenomyosis.Methods 76 patients diagnosed with circumscribed adenomyosis from March 2013 to November 2014 in our hospital were selected as the research group，all of the enrolled patients requested to preserve their reproductive function.All patients were randomly divided into the control group and the observation group，38 cases in each group.The control group was treated with trans-abdominal adenomyomectomy，the observation group was treated with trans-abdominal adenomyomectomy combined with UAB.The related clinical indexes of the two groups after operation at 3，6，12monthswas compared，and the efficacy of the trans-abdominal adenomyomectomy combined with UAB was evaluated.Results The post-operative VASscores of dysmenorrheal in the observation group was lower than that in the control group，with significant difference（P＜0.01）.The remission rate of dysmenorrhea in the observation group was higher than that in the control group，with significant difference　（P＜0.05）.The ineffective or exacerbation rate of dysmenorrhea in the observation group was lower than that in the control group，with significantdifference　（P＜0.05）.The recurrence rate of the observation group was lower than that of the control group，with significant difference（P＜0.05）.The incidence rate ofmenstrual blood loss in the observation group was higher than that in the control group，with significant difference　（P=0.03）.The level of AMH after operation at 3，6 months in the observation group was lower than that in the control group，with significant difference（P＜0.05）.There was no significant difference in the level of AMH after operation at 12months between the two groups（P＞0.05）.Conclusion Trans-abdominal adenomyomectomy combined with UAB has satisfying effectiveness and has no reverse impact on ovarian function.Comparing with simple trans-abdominal adenomyomectomy，it has a superior efficacy in extinguishing and relieving dysmenorrhea，reducingmenstrual blood loss and recurrent rate within one year after surgery.This surgery has good feasibility in primary hospitals because of itsmoderate technical difficulty. 2016 Vol. 23 (26): 64-67 [Abstract] ( 146 ) HTML (38 KB)  PDF  (0 KB)  ( 31 ) 68 Analysis of the advantages of the im proved lateral episiotom y in the app lication of prim ipara with vaginal delivery XIE Feng-yun Objective To explore the advantages of themodified lateral episiotomy in the application of primipara with vaginal delivery.Methods 100 primipara with vaginal delivery from January 2013 to December 2015 in our hospital were selected and divided into the control group and the observation group according to the random number table method，50 cases in each group.The control group was given the traditional lateral episiotomy，and the observation group was given themodified lateral episiotomy.The incision suture time，the amount of bleeding during operation，hospital stay，pain score，incision healing grade and the incidence rate of complication was compared between the two groups.Results The incision suture time，postpartum hospital stay in the observation group was shorter than that in the control group，the amount of bleeding during operation in the observation group was less than that in the control group，the pain score in the observation group was lower than that in the control group，with significant difference　（P＜0.05）.The incision healing situation A in the observation group was better than that in the control group，with significant difference　（P＜0.05）.The incidence rate of complication of the observation group wa lower than that of the control group，with significant difference（χ2=0.891，P=0.027）.Conclusion In the process of vaginal delivery of primipara，the implementation ofmodified lateral episiotomy can shorten the incision suture time of patients，reduce the incidence of postpartum pain，reduce the incidence of complications，and promote postpartum wound healing. 2016 Vol. 23 (26): 68-70 [Abstract] ( 171 ) HTML (33 KB)  PDF  (0 KB)  ( 30 ) 71 Clinical effect study of nutrition guidance during pregnancy in obstetrics clinic HE Li； TANG Yan-ping Objective To explore the clinical effect of prenatal nutrition guidance in obstetrics clinic.Methods 100 cases of pregnantwomen in our hospital from January 2013 to January 2016 who were willing to receive nutrition guidance during pregnancy were selected as the observation group，in the same year，100 pregnantwomen who were notwilling to receive nutrition guidance during pregnancy were selected as the control group.The detection condition of bonemineral density in the late pregnancy，the condition of delivery and the newborn and the incidence rate of pregnancy complications in the two groupswas compared.Results The detection condition of bonemineral density in the late pregnancy in the observation group was better than that in the control group，with significant difference（P＜0.05）.The condition of delivery and the newborn in the late pregnancy in the observation group was better than that in the control group，with significant difference　（P＜0.05）.The incidence rate of pregnancy complication in the observation group was 9.00%，which was lower than 19.00%in the control group，with significant difference　（P＜0.05）.Conclusion Pregnancy nutrition guidance in obstetrics clinic can effectively reduce the incidence rate of pregnancy complications，improve natural childbirth rate，pregnancy outcome is considerable，which can improve the quality of obstetric outpatient service.It can effectively reduce the incidence of pregnancy complications，improve the natural delivery rate，and improve the quality of obstetric clinic. 2016 Vol. 23 (26): 71-73 [Abstract] ( 176 ) HTML (33 KB)  PDF  (0 KB)  ( 32 ) 74 Analysis of the clinical outcomes of in vitro fertilization and embryo transfer cycles ZENGWei-rong ；CAIGui-Feng ；LU Yong-Ming； ZHAO-Qin Objective To explore the influence of the frequency of the repeated cycles of in vitro fertilization and embryo transfer on the clinical outcome of the patients and its causes，to study the related factors of failure of recurrent in vitro fertilization and embryo transfer.Methods 469 caseswho received in vitro fertilization and embryo transfer in the reproductive center of our hospital from January to December in 2015 were selected and divided into the group A　（326 cases）and group B（143 cases）according to the repeat frequency.Group A was repeated cycle 1，while group B was repeated cycle greater than or equal to 2.The age，duration of infertility，HCG thickness of the endometrium，GN dosage，the number of follicles，oocytes and cleavage rate，high quality embryo rate and clinical pregnancy rate was compared between two groups.Results The age and the amount of Gn in group A was less than that group B，with significant difference　（P＜0.05）.The number of follicles，the number of eggs，the clinical pregnancy rate in group A was higher than that oin group B，with significant difference　（P＜0.05）.There was no significant difference in the duration of infertility，HCG thickness of the endometrium between group A and group B（P＞0.05）.There was no significant difference in the oocytes and cleavage rate，high quality embryo rate between the two groups（P＞0.05）.Conclusion In the cycle of different repetition frequency，the difference of age directly affects the clinical outcome，The clinical pregnancy outcome of repeated in vitro fertilization and embryo transfer failure in patientsmay be improved by proper improving the amount of Gn，optimizing the environment and technology of the embryo lab. 2016 Vol. 23 (26): 74-76 [Abstract] ( 154 ) HTML (32 KB)  PDF  (0 KB)  ( 30 ) 77 Clinical analysis of Lysine Inositol and Vitam in B12in the treatment of children with anorexia CHEN Hai-ping ；HUANG Bai-zhi ；HONG Yu-ling； LIU Dan；　LIANGMu-hua Objective To explore the clinical effect of Lysine Inositol and Vitamin B12in the treatment of children with anorexia.Methods 83 children with anorexia in our hospital from January 2014 to October 2015 were selected and divided into the routine group　（41 cases）and the experimental group　（42 cases）according to the difference of treatment method.The routine group was treated with Zinc and Calcium Gluconate Tablets，the experimental group was treated with Lysine Inosite and Vitamin B12oral liquid on the basis of the routine group.The total effective rate，the levels of iron，calcium and zinc trace element and body weight of children before and after intervention in the two groupswas compared，the incidence of adverse reactions in the two groups was recorded.Results The total effective rate in the experimental group was higher than that in the routine group，with significant difference　（P＜0.01）.The level of iron，calcium and zinc trace element after intervention in the experimental group was higher than that in the routine group after intervention，with significant difference　（P＜0.05）.The level of body weight after intervention in the experimental group was higher than that in the routine group after intervention，with significant difference　（P＜0.05）.There were no significant adverse reactions，no nausea and vomiting，no liver and kidney dysfunction or rash in the two groups.Conclusion Lysine Inositol and Vitamin B12has definite clinical effect in the treatment of children with anorexia，which can effectively improve the children′s appetite，improve the body trace element levels and nutrient levels，increase body weight，and has the advantages of high safety，less adverse reaction，it isworthy of clinical promotion and application. 2016 Vol. 23 (26): 77-79 [Abstract] ( 171 ) HTML (36 KB)  PDF  (0 KB)  ( 33 ) 80 Analysis of the econom ic benefits of ultra fast track surgery for ventricular septal defect in children TAN Xiao-li Objective To explore the economic benefits of ultra fast track surgery for ventricular septal defect in children.Methods 53 children with ventricular septal defect underwent ultra fast channel ventricular septal defect repair in our hospital from May to July in 2015 in our hospitalwere selected as the super fast track group，65 children with ventricular septal defect underwent traditional repair of ventricular septal defect in our hospital from May to July in 2014 in our hospital were selected as the traditional operation group.The length of stay，the cost of hospitalization，the utilization rate of the bed and the residence time of themonitoring room in the two groupswas compared，the economic benefit of ultra fast track surgery in the repair of ventricular septal defect was evaluated.Results The length of stay，the residence time of themonitoring room in the super fast track group was shorter than that in the traditional operation group，the cost of hospitalization in the super fast track group was less than that in the traditional operation group，the utilization rate of the bed in the super fast track group was shorter than that in the traditional operation group，with significant difference（P＜0.01 or P＜0.05）.Conclusion The economic benefits of ultra fast track surgery in the treatment of pediatric ventricular septal defect is better than that the traditional operationmethod. 2016 Vol. 23 (26): 80-82 [Abstract] ( 163 ) HTML (32 KB)  PDF  (0 KB)  ( 31 ) 83 Analysis on the causes of hemorrhage after low-tem perature p lasma tonsillectom ies ZHANG Da-wei ；CHEN Ren-jie▲ Objective To analyze the causes of hemorrhage after low-temperature plasma tonsillectomies so as to provide clinical evidences for the prevention of postoperative hemorrhage.Methods A retrospective analysiswas performed on 227 patients who underwent low-temperature plasma tonsillectomies in the hospital from January 2014 to June 2015.The clinical data of patients containing general clinical data and postoperative hemorrhage（including the hemorrhage site and type）were collected and recorded.Results Among 227 patients who were involved in this study and underwent low-temperature plasma tonsillectomies，postoperative hemorrhage occurred in 11 cases（accounting for 4.8%），including primary hemorrhage in 4 cases and delayed hemorrhage in 7 cases.Of the 11 cases of postoperative hemorrhage，2 cases were located in the upper pole of amygdaloid fossa；1 case of diffuse hemorrhage was located inside the amygdaloid fossa；8 caseswere located in the inferior pole of amygdaloid fossa.Conclusion Postoperative hemorrhage in the upper pole of amygdaloid fossa accounts for a larger proportion.The causes of hemorrhage after low-temperature plasma tonsillectomies include unthorough intraoperative hemostasis，postoperative infections，improper postoperative diets，which can be prevented symptomatically. 2016 Vol. 23 (26): 83-85 [Abstract] ( 165 ) HTML (31 KB)  PDF  (0 KB)  ( 39 ) 86 Clinicalobservation of vocal cord polyp excision underm icroscope support LIU Ye-ning ；FANG Chao-xin； LAIQi-min Objective To discuss the clinical efficacy of vocal cord polyp surgery undermicroscopic support.Methods Clinical data of 50 patients with vocal cord polyp from January 2014 to January 2016 were respectively analyzed.25 cases of control group were treated with the removal of the fiber under nasal endoscope under general anesthesia，and 25 cases of study group were treated with microscopic support for the removal of polyps under general anesthesia.Improvement of acoustic parameters，operation time and development of two groupswere compared.Results After treatment，pedicle vocal cord poyps patients with basic frequency perturbation，amplitude perturbation，standardized noise energy and other indicators of two groups was better than that before treatment respectively（P＜0.05）.After treatment，pedicle vocal cord polyps patientswith basic frequency perturbation，amplitude perturbation，standardized noise energy and other indicators of two groups was better than that before treatment respectively，and better than that of control group after treatment respectively（P＜0.05）.Complication rate of control group was 12.0%（3/25），and study group was 16.0%（4/25），which showed no significant difference between two groups（P＞0.05）.Conclusion Microsurgical treatment of vocal cord polypswithmicroscopic supporthas a good clinical effect，especially for sessile vocal cord polyp. 2016 Vol. 23 (26): 86-88转92 [Abstract] ( 119 ) HTML (37 KB)  PDF  (0 KB)  ( 37 ) 89 Evaluation of clinical effect of loratadine and phenylsulfonic bepotastine besilate in the treatment of rhinallergosis HUANG He；LIMan-lan；WANG Dong-yan；ZHANGGui-yang；ZHANG Han-wen Objective To discuss the clinical treatment effect of loratadine and phenylsulfonic bepotastine besilate in the treatment of rhinallergosis.Methods Ninety-eight cases of patients with rhinallergosis in our hospital from March 2014 to April 2016 were selected and divided into group A and group B according to the time of admission.The group A were treated with loratadine，while the group B were treated with phenylsulfonic bepotastine besilate.The levels of IgE and ECP，clinical signs and symptoms，adverse reactions and VAS scores in the two groupswere observed and compared，then the clinical treatment effect was compared in the two groups.Results The total effective rate in the group B was significantly higher than that in the group A，the difference was statistically significant（P＜0.01）.After treatment，The levels of IgE and ECP in the group B was obviously lower than that in the group A respectively，with significant differences （P＜0.01）.The scores of clinical signs and symptoms in the group B was obviously lower than that in the group A respectively with significant differences（P＜0.01）.After treatment，the VAS scores of two groupswas significantly lower and the VAS score of group B was lower than that of group A，the difference was statistically significant（P＜0.01），the incidence rate of adverse reactions of group B was significantly lower than that in the group A，and the differenceswere statistically significant（P＜0.05）.Conclusion The clinical treatment effect of phenylsulfonic bepotastine besilate in the treatment of rhinallergosis is better than that of loratadine，which isworthy promotion in clinic. 2016 Vol. 23 (26): 89-92 [Abstract] ( 153 ) HTML (41 KB)  PDF  (0 KB)  ( 34 ) 93 Com parison on hemodynamic responsesof AirtraqRvideolaryngoscope，UE videolaryngoscope and Macintosh laryngoscope orotracheal intubation in elderly patientswithout difficult intubation WANGWei-hua；　MA Li ；LIShan-yi Objective To compare the hemodynamic responses of AirtraqRvideolaryngoscope，UE videolaryngoscope and Macintosh laryngoscope in elderly patients without difficult intubation.Methods 60 elderly patients scheduled for surygery under general anesthesia requiring orotracheal intubation from August 2015 to May 2016 were randomly allocated to three group.After intravenous anesthetic induction，orotracheal intubation was performed with AirtraqRvideolaryngoscope，UE videolaryngoscope or Macintosh laryngoscope.Parameters records included glottic exposure time，tracheal intubation time and noninvasive heart rate　（HR），systolic blood pressure（SBP）and diastolic blood pressure（DBP）before（T0）and after anesthetic induction（T1），0 min（T2），1 min（T3），3 min（T4），5 min（T5）after intubation.Rate-pressure product（RPP）and the total time of intubation were calculated.Results The glottic exposure time in group A was significantly longer than that in group Mand group U（P＜0.05），while the tracheal intubation time in group A was significantly shorter than that in group Mand group U（P＜0.05）.The total time of intubation was no statistically significant difference （P＞0.05）.Compared with T0，the SBP，DBP and RPP of three groups at T1decreased significantly　（P＜0.05），but the HR didn′t change remarkably.Compared with T1，SBP，DBP and RPP at T2，T3in group A increased significantly　（P＜0.05）.In group Mand group U，HR，RPP at T5，SBP，DBP，HR and RPP at T2，T3and T4increased significantly compared with T1（P＜0.05）.In group Mand group U，HR and RPP at T5，SBP，DBP，HR and RPP at T2，T3and T4were significant higher than those in group A.Conclusion In comparison to the UE videolaryngoscope and Macintosh laryngoscope，tracheal intubation with the AirtraqRvideolaryngoscope resulted in less alterations in hemodynamic responses in elderly patients without difficult intubation. 2016 Vol. 23 (26): 93-96 [Abstract] ( 154 ) HTML (41 KB)  PDF  (0 KB)  ( 29 ) 97 Intubation laryngoscope photopic im pact analysis of the target concentration of anesthesia and anesthetic effects of general anesthesia patients XU Yong-min；FU Yan-shi Objective To study the bright laryngoscope for endotracheal intubation and anesthesia anesthesia target concentration of patients for clinical anesthesiology.Methods 68 cases of patients undergoing general anesthesia for surgery between May 2011 to September 2015 in our hospitalwere selected as an object，depending on themode of intubation patients were divided into two groups and 34 patients in each group.The observation group were treated by photopic laryngoscope tracheal intubation，the control group was treated with the traditional direct laryngoscopy.In the process of patients with anesthesia，anesthesia in usage of induction drugs and methods of use of propofol were the same，the sequential determination of patients for half effective target propofol inhibit stress reaction controlled concentration analysis，photopic laryngoscope for general anesthesia with tracheal intubation anesthesia and the anesthetic effect of target controlled concentration of patients.Results The heart rate andmean arterial pressure before and after anesthesia of observation group compared with the control group，the difference was not statistically significant（P＞0.05）.The patients in the observation group during intubation for heart ratewas（83.5±9.1）/min，themean arterial pressure was（19.2±2.2）kPa，patients in the control group during intubation for heart rate was（104.5±9.6）/min，themean arterial pressure was（26.5± 3.4）kPa，there was significant difference between two groups（P＜0.05）.Conclusion Laryngoscope photopic patient during general anesthesia，the anesthetic effect in patientswith good hemodynamic stability display and should be introduced in clinical anesthesiology. 2016 Vol. 23 (26): 97-99 [Abstract] ( 126 ) HTML (31 KB)  PDF  (0 KB)  ( 34 ) 100 Clinical research of X-ray and MRI of ank le fracture in the diagnosis of lower tibia and fibula combined injury LIU Jing-ming Objective To explore the application value of ankle fracture X-ray and MRI in the diagnosis of lower tibia and fibula combined injury.Methods 56 patients with ankle fracture conducted Lauge-Hansen type and Denis-Weber type from November 2013 to November 2015 in our hospital were selected as study objects.Fracture type and X-ray measurementwere organic combined.The integrity of lower tibia and fibula combined injury was evaluated according to MRI，the sensitivity，specificity and correlation of X-ray and MRI in the diagnosis of lower tibia and fibula combined injury was analyzed.Results According to MRIdiagnosis，X-raymeasurement and Weber type combination，the sensitivity was 49%，and the specificity was 100%；the sensitivity of LH type was 93%，and the specificity of LH type was 94%，and ligament injury could not be judged by 2 types，but in the field of damage judgment，LH type had many generality with MRI inspection result.Conclusion Early diagnosis and treatment of acute lower tibia and fibula combined injury is the key and prerequisite for the treatment of patients，combination LH type and X-ray can judge whether ankle patients with lower tibia and fibula combined injury，while the specific diagnosis of the injury degree of the tibia and fibula ligament，MRI is recommended to use formaking a detailed diagnosis. 2016 Vol. 23 (26): 100-102 [Abstract] ( 131 ) HTML (30 KB)  PDF  (0 KB)  ( 29 ) 103 Clinical app lication value of CTA vascular imaging scanning technology in the diagnosing of cerebral aneurysm ZHONG Xiang；　BAN Mei-lei； LU Yao-ri Objective To explore the clinical application value of CTA vascular imaging scanning technology in the diagnosing of cerebral aneurysms.Methods 200 cases of subarachnoid hemorrhage caused suspected cerebral aneurysm in our hospital from January 2015 to June 2016 were selected and conducted CTA examination.Image post-processing methodsincludedmaximum intensityprojection（MIP），volume rendering（VR），curved reformat（CR）andmulti-planar reformats （MPR），and arterial aneurysm clipping surgery was regarded as diagnostic criterion for aneurysm.Results 200 cases of paitients with CTA examination showed 195 aneuruysms，190 aneurysms were confirmed by aneurysm clipping operation，4 cases of false negative，1 case of false-positive.DSA examination showed 189 cases of aneuruysm，5 cases of false negative，1 case of false-positive.The sensitivity，specificity，positive predictive value，negative predictive value and accuracy of CTA in cerebral aneurysms diagnosis was 97.4%，83.3%，99.5%，55.6%，and 97.5%respectively.The sensitivity，specificity，positive predictive value，negative predictive value and accuracy of the control group of DSA in cerebral aneurysms diagnosiswas 96.9%，83.3%，99.5%，50.0%，and 97.5%respectively.Conclusion Head and neck CTA examination in the diagnosis of cerebral aneurysms is fast，safe，non-invasive，effective and so on，which can be used as the first choice for clinical screening of cerebral aneurysms. 2016 Vol. 23 (26): 103-105 [Abstract] ( 147 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 106 App lication com parison of enhanced CT and color Dopp ler ultrasound in the diagnosis of acute pancreatitis JIANG Fa-liang；　LIN Cai-hong Objective To explore the application value of enhanced CT and color Doppler ultrasound in the diagnosis of acute pancreatitis（AP）.Methods96 casesof AP in our hospital from March 2014 to March 2016 were selected as research subjects，color Doppler ultrasound and enhanced CT examination were given.The imaging manifestations and diagnosis of two kinds of examinationmethodswas observed.Results The ratio of pancreatic duct dilatation and common bile duct stones of color Doppler ultrasound was higher than that of enhanced CT（P＜0.05），but the ratio of the limitation enlargement of pancreas，focal necrosis of pancreas liquefaction of color Doppler ultrasound was lower than that of enhanced CT，with significant difference（P＜0.05）.The AP detection rate of enhanced CTwas higher than that of color Doppler ultrasound，with significant difference（P＜0.05）.The AP detection rate of bleeding and necrotizing of enhanced CTwas higher than thatof color Doppler ultrasound，with significantdifference（P＜0.05）.Therewasno significantdifference in the edematous AP detection rate between the two kinds of examinationmethods（P＞0.05）.Conclusion Color Doppler ultrasound and enhanced CT in acute pancreatitis diagnosis and also has high value，which can be combined in clinical use，in order to effectivelymake up for defects，this is of great significance for the diagnosis，treatment and prognosis of AP. 2016 Vol. 23 (26): 106-108 [Abstract] ( 136 ) HTML (32 KB)  PDF  (0 KB)  ( 19 ) 109 App lication value analysis of MRI and X ray in staging diagnosis ofmultip lem yeloma LIU jie；　DONG Yu-long Objective To compare the MRI and X ray performance ofmultiplemyeloma in different stages，and to improve the diagnostic level ofmultiple myeloma.Methods 72 cases of multiple myeloma patients in our hospital from April 2011 to March 2015 were selected and confirmed by bonemarrow puncture and biopsy.MRIand X-ray imaging data of all patients were analyzed，and the difference of the twomethods in the staging diagnosis ofmultiplemyeloma was compared.Results 72 patients with multiple myeloma had 120 involved diseased regions.MRI evaluation revealed 61 cases（84.72%）ofmultiplemyeloma patients，and 102 regions（85.00%）were detected.X-ray examination revealed 46 cases（63.89%）ofmultiplemyeloma patients，and 78 regions（65.00%）were detected.The detection rate of the patients and the detection of involved sites of MRIwas higher than that of the X-ray，with significant difference　（P＜0.01）. The staging of X-ray examination was 26 cases of stageⅠ，28 cases of stageⅡ，18 cases of stageⅢ.MRIexamination stage was 14 cases of stageⅠ，19 cases of stageⅡ，39 cases of stageⅢ，and there was significant difference in the staging ofmultiplemyeloma between the twomethods（P＜0.01）.Conclusion The detection rate ofmultiplemyeloma in MRIis higher than that of X-ray，and the effect of staging diagnosis is better. 2016 Vol. 23 (26): 109-111 [Abstract] ( 125 ) HTML (34 KB)  PDF  (0 KB)  ( 35 ) 112 Clinical observation of Bosentan combined with Sildenafil in the treatment of congenital heart disease with severe pulmonary arterial hypertension AI ling-Yun；　GUO Chen；　DING Yan；　CHEN Xia Objective To explore the effect of Bosentan combined with Sildenafil in the treatment of congenital heart disease（CHD）with severe pulmonary arterial hypertension（PAH）.Methods 61 patients diagnosed with CHD with severe PAH from September 2012 to December 2015 in our hospitalwere selected and divided into the control group（30 cases）and the treatment group　（31 cases）according to the random number tablemethod.All the patients were treated with routine treatment，the control group was treated with Sildenafil on the basis of routine treatment，the treatment group was treated with Bosentan on the basis of the control group.The level of brain natriuretic peptide　（BNP），dyspnea score （Borg score），oxygen saturation　（SpO2）level，the grade of cardiac function classification and the improvement of right heart catheterization results before and after treatment in the two groups was compared.Results The level of brain natriuretic peptide　（BNP），Borg score，NYHAFC score after treatment in the treatment group was lower than that before treatment and the control group after treatment，the level of SpO2after treatment in the treatment group was higher than that before treatment and the control group after treatment，with significant difference（P＜0.05）.The level of Pp/Ps，sPAP，mPAP after treatment in the treatment group was lower than that before treatment and the control group after treatment，the level of Qp/Qs after treatment in the treatment group was higher than that before treatment and the control group after treatment，with significant difference　（P＜0.05）.Conclusion The effect of Bosentan combined with Sildenafil in the treatment of CHD with SPH is significant，which can improve the cardiopulmonary function better，with higher qualified life level，it isworthy of clinical promotion and application. 2016 Vol. 23 (26): 112-114 [Abstract] ( 132 ) HTML (33 KB)  PDF  (0 KB)  ( 31 ) 115 The clinical app lication of coronary heart disease com pared with COPD cardiac by bisoprolol unite trimetazidine LUO Yan-shan Objective To approach clinical effects of coronary heart disease compared with COPD cardiac patients by bisoprolol unite trimetazidine.Methods 116 patients with coronary heart disease compared with COPD cardiac in the central hospital of Panyu district from February 2014 to December 2015 were analyzed.They were randomly divided into two groups.56 cases in the control group were given digoxin+metoprolol conventional therapy methods，and 60 cases in observation group were given bisoprolol unite trimetazidine therapymethods.The left atrium diameter，left ventricular end-diastolic diameter，LVEF，6 min traveled distance，clinical treatment total effective rate of two groupswere detected. Results Before treatment，there was no significant difference in cardiac function indexes between the two groups（P＞0.05）.Therewas no significant difference in cardiac function indexes before and after treatment in the control group（P＞0.05）.The left atrial diameter of before and after treatment in the observation group were compared，the difference was not statistically significant（P＞0.05）；after treatment，the left ventricular end diastolic diameter，left ventricular ejection fraction and 6 min walking distance of the observation group was better than that of before treatment respectively，and better than that of the control group（P＜0.05）.The clinical treatment efficiency of observation group was statistically higher than that of control group，with statistical difference（P＜0.05）.Conclusion The coronary heart disease compared with COPD cardiac patients by bisoprolol unite trimetazidine，which can improve cardio-pulmonary function of patients，increase clinical treatment total effective rate，it isworth to be used. 2016 Vol. 23 (26): 115-117 [Abstract] ( 147 ) HTML (32 KB)  PDF  (0 KB)  ( 31 ) 118 Value analysis of Huangkui capsule combined with Tripterygium wilfordii tablets in the treatment of diabetic nephropathyⅣ LIAOWen；　XU Lin-fang Objective To analyze the clinical application value of Huangkui capsule combined with Tripterygium glucoside tablets in the treatment of stage of diabetic nephropathy.Methods 96 patients with stageⅣ diabetic nephropathy in the hospital from July 2014 to July 2015 were selected as the research object.They were divided into observation group and the control group，43 cases in the control group，with Huangkui capsule in the treatment，observation group（53 cases）with Huang Kui capsule combined with Tripterygium wilfordiimulti glycoside tablet in the treatment.The 24 h urine protein，blood urea nitrogen，triglyceride，serum creatinine level of the two groups before and after treatment one month after treatment，twomonths after treatment，threemonthswere detected and compared.Results The effective rate of the observation group was significantly higher than that of the control group，the difference was statistically significant （P＜0.01）.After treatment，most patientswith liver and renal function improved，blood protein increased，the levels declined and at the same time contrast observation group were significantly better than the control group，the difference had statistical significance　（P＜0.05）.No serious adverse reactions occurred in the two groups.Conclusion Huangkui capsule and Tripterygium glycosides tablet can significantly improve the clinical effect of the treatment of diabetic nephropathy Ⅳand can be popularized in clinical treatment. 2016 Vol. 23 (26): 118-120 [Abstract] ( 130 ) HTML (35 KB)  PDF  (0 KB)  ( 36 ) 121 Effect analysis of arginine combined with naloxonein in treatment of liver cirrhosis complicated with hepatic encephalopathy CHENG He-zhen；　ZHANG Zhong-yuan Objective To investigate the effect of arginine combined with naloxone in treatment of hepatic cirrhosis complicated with hepatic encephalopathy therapeutic.Methods 106 cases of liver cirrhosis complicated with hepatic encephalopathy patients in our hospital outpatient or inpatient treatment from April 2010 to March 2013 were divided into two groups according to the different treatment time，53 cases in each group；the control group was given naloxone infusion therapy，the treatment group was given naloxone and arginine infusion for treatment.The effect of two groups before and after treatment，blood ammonia，serum totalbilirubin（TBil），alanineaminotransferase（ALT），glutamic oxaloacetic transaminase　（AST）level changes，the incidence of adverse reaction were compared.Results The total effective rate of treatment group after treatment was 90.57%，significantly higher than 75.47%in control group，and the difference was statistically significant（P＜0.01）；after treatment，blood ammonia，TBil，ALT，AST levels of two groupswas significantly lower than that before treatment respectively，with statistical difference（P＜0.01）；blood ammonia，TBil，ALT，AST levels decreased after treatment in treatment group was better than that of control group after treatment（P＜0.01）；the two groups of patients during treatment had no obvious adverse reaction.Conclusion Curative effect of arginine combined with naloxone in treatment of liver cirrhosis complicated with hepatic encephalopathy is definite. 2016 Vol. 23 (26): 121-123 [Abstract] ( 147 ) HTML (35 KB)  PDF  (0 KB)  ( 29 ) 124 Effects com parison of two kinds of angiotensinⅡ receptor antagonists liked losartan and valsartan in intervention uric acid metabolism in patientswith hypertension HU Ni ；WUWen-bin Objective To explore the clinical effects of two kinds of angiotensinⅡ receptor antagonists liked losartan and valsartan in intervention uric acid metabolism in patients with hypertension.Methods 70 patients who treated in our hospital from April 2014 to January 2016 were divided into losartan group（38 cases）and valsartan group（32 cases）according to the admission order.Patients in two groupswere respectively given two kinds of angiotensinⅡreceptor antagonists liked losartan and valsartan for treatment.The level of serum uric acid and blood pressure were respectively compared pretreatment，treatment for 4 weeks and after treatment for 8 weeks.Results With the treatment，the level of SBP and DBP in two groups gradually reduced.After treatment for 4 weeks and 8 weeks，the level of SBP and DBP between two groups had no statistical significance　（P＞0.05）.During the treatment，the level of serum uric acid in losartan group gradually reduced，but the level of serum uric acid in valsartan group had no obvious changes.After treatment for 4 weeks and 8 weeks，the level of serum uric acid between two groups had obvious difference（P＜0.01）.Conclusion The antihypertensive effect of two kinds of angiotensinⅡ receptor antagonists liked losartan and valsartan is equal，while losartan can improve the uric acid metabolism of hypertension patients and obvious decrease the level of serum uric acid. 2016 Vol. 23 (26): 124-126 [Abstract] ( 115 ) HTML (32 KB)  PDF  (0 KB)  ( 30 ) 127 Analysis of the clinical efficacy and safety on NBP injection in the treatment of vascular dementia JIANG Qian Objective To investigate the NBP injection in the treatment of vascular dementia（VD）clinical efficacy and safety.Methods 110 cases of patientswith VD from February 2014 to February 2016 period in our hospitalwere selected and were divided into study group and control group according to the grouping principles.The control group were used oxiracetam，the study group were used application NBP injection treatment on this basis.The therapeutic effect and safety of the two groupswere observed and compared.Results The total effective rate in the study group of VD patients was 90.91%，higher than that in the control group of 74.54%　（P＜0.05）.After the treatment，the study group MMSE score was higher than before treatment（P＜0.05），the ADL scoreswas lower than that of the control group（P＜0.05）.During and after treatment showed no significant adverse reactions.Two groups before and aftermedication urea nitrogen，creatinine，ALT and AST level comparison difference had no statistical significance（P＞0.05）.Conclusion NBP VD injection therapy is effective，safety and good，it is suitable for clinical practice. 2016 Vol. 23 (26): 127-129 [Abstract] ( 111 ) HTML (32 KB)  PDF  (0 KB)  ( 33 ) 130 Clinical effect of Xiaoyong Kuidekang"cause-testifying by efficacy"in the treatment of gastric ulcer in the pattern of gastric toxic heat syndrome ZHANG Xi ；CHENMing-jin；　YU Guo-wei Objective To explore the clinical effect of using Xiaoyong Kuidekang Granules on treating patients with gastric ulcer and provide a scientific basis on aetiological theory of gastric toxic heat syndrome in gastric ulcer patients. Methods From April 2015 to April 2016，300 patients with gastric ulcer from outpatient clinic and inpatientwards in our hospital were selected as research objects and evenly divided into three groups by a random number table.In quadruple group of Xiaoyong Kuidekang，quadruple therapy of Xiaoyong Kuidekang was provided；in single group of Xiaoyong Kuidekang，only Xiaoyong Kuidekang was used；in quadruple group of Bi，bismuth potassium citrate as quadruple therapy was adopted.The total effective rate，therapeutic effective rate ofmain symptoms，and syndrome score of traditional Chinesemedicine　（TCM）after therapy among three groupswere compared and analyzed.Results The total effective rate 96%，and syndrome score of TCM［（1.76±0.41）scores］after therapy in quadruple group of Xiaoyong Kuidekang weremuch better than those in the single group of Xiaoyong Kuidekang［87%，（3.27±0.55）scores］and quadruple group of Bi［85%，（4.03±0.78）scores］，therapeutic effective rate ofmain symptoms also had a statistical difference after intergroup comparison　（P＜0.05）.Conclusion Application of Xiaoyong Kuidekang Granules can obtain a remarkable clinical effect in treatment of patients with gastric ulcer.Meanwhile，ulceration induced by heat toxins syndrome is proved through"cause-testifying by efficacy".Application of Xiaoyong Kuidekang to clear heat and resolve toxin is worthy of promotion. 2016 Vol. 23 (26): 130-132转136 [Abstract] ( 154 ) HTML (35 KB)  PDF  (0 KB)  ( 12 ) 133 Cost-effect analysisof 2 kinds of traditional Chinese and W esternmedicine in treatment of common type hand foot and mouth disease XIAO Shan；LIU Li-ying；ZHENG Rui-qing；LIU Yan-qing；CHEN Chun-lian；WEN Wei Objective To explore the cost and clinical effect of 2 kinds of Chinese and Western combined therapy for common type hand foot and mouth disease.Methods 100 cases of children with common hand foot and mouth disease in our hospital from May to August 2015 were selected as research object and divided into group A and group B by random number table，each group was 50 cases.Patients in group A were treated with Xiyanping and Ribavirin，while in group B with Infantile Niuhuang Qingxinsan+Vidarabine Monophosphate，treatment effect，improvement of symptoms and signs and adverse reaction between two groups were compared，the two kinds of therapies were analysed for economic. Results Total effective rate of group A with 94%was significantly higher than 82%of group B，the difference was statistically significant（P＜0.05）.Antipyretic time and disappearance time of clinical symptoms（signs）etc.in group A were significantly shorter than those in group B　（P＜0.05）.The adverse reaction incidence of group A was slightly lower than that of group B，and the difference had no statistical significance　（P＞0.05）.The hospital stays and medical expenses of group A were significantly less than that of group B　（P＜0.05）.Conclusion Clinical effect of Xiyanping and Ribavirin combination of Chinese and Western in treatment of common type of hand foot and mouth disease is reliable，which has the advantages of quick effect，short course of treatment，less adverse reaction and so on，and low cost，economy is better. 2016 Vol. 23 (26): 133-136 [Abstract] ( 139 ) HTML (39 KB)  PDF  (0 KB)  ( 31 ) 137 Research on the level change and diagnostic significance of serum tumor markers CEA，CA125 and NSE in patientswith lung cancer HU Jian-xin；　XIONG Zhi-min Objective To investigate the level changes and its diagnostic significance of serum tumor markers in patients with lung cancer.Methods The expression of NSE，CA125 and CEA in the serum samples of lung cancer group，lung cancer group and healthy control group were detected by Roche Elecsys 2010 electrochemical luminescence immunoassay，the detection results of CEA，CA125 and NSE expression in three groups of serum samples were analyzed. Results The levels of serum CEA，CA125 and NSE in lung cancer group were significantly higher than the other two groups，and the difference was statistically significant（P＜0.05）.There were no significant difference between benign lung disease group and healthy control group（P＞0.05）.The expression levels of CEA and NSE in lung adenocarcinoma and small cell carcinomawere higher than the other two groups，the differenceswere statistically significant（P＜0.05）. Therewas no significant difference in the expression level of CA125 between the three groups（P＞0.05）.The sensitivity and specificity of CEA was 46.56%and 96.31%，higher than the other two indicators.Conclusion The expression of CEA，CA125 and NSE is closely related to the occurrence and development of lung cancer.The expression of CEA and NSE in lung adenocarcinoma and small cell carcinoma are higher，and the sensitivity and specificity of CEA are higher. It can provide a reference value for the further study of lung cancer. 2016 Vol. 23 (26): 137-139 [Abstract] ( 142 ) HTML (33 KB)  PDF  (0 KB)  ( 35 ) 140 Clinic app lication value in early and rapid diagnosis of dengue fever by combined detection of NS1 antigen and RNA nucleic acid of dengue virus FANGWei-zhen；CAIZhen-hua；LIJian；LIJing；LIHong-yu Objective To investigate the application under combined detection of NS1 antigen and RNA nucleic acid of dengue virus in early and rapid diagnosis of dengue fever.Methods 366 clinically dengue fever suspected cases of serum sampleswere collected from outpatients and inpatients during the epidemic dengue virus typeⅠin Guangdong in June to November 2014，while the detection of dengue virus NS1 antigen by ELISA and RNA nucleic acid by PCR fluorescence probemethod，and then the resultwas compared.Results Dengue NS1 antigen test positive rate was 94.8%；dengue RNA nucleic acid testing positive rate was 95.9%，the positive rate of joint detection was 97.3%.The positive rate of combined detection was higher than the other two.Conclusion NS1 antigen and RNA nucleic acid of dengue virus can be used for early and rapid diagnosis of dengue fever，combined detection of the two has a higher positive rate. 2016 Vol. 23 (26): 140-142 [Abstract] ( 109 ) HTML (35 KB)  PDF  (0 KB)  ( 33 ) 143 App lication value of liver biochem ical function test in the evaluation of hepatitis B cirrhosis HE Dan-feng　；MA Ling-bo Objective To investigate the clinical value of detection of liver biochemical function in hepatitis B liver cirrhosis（HBC）.Methods From January 2014 to March 2016，52 cases of HBC in our hospitalwere selected as the observation group according to the Child-Pugh classification criteria for grading.52 cases of healthy personswere selected as the control group.The liver biochemical indexes of all the subjects were tested and compared.Results Compared with the control group，the level of serum ALT，AST，ALP，TBil and TBA and DBil in the observation group significantly increased（P＜0.05），while ALB，TPand A/G decreased significantly（P＜0.05）.Various liver function indexesof differentChild-Pugh grades were significantly different（P＜0.05）.Conclusion The liver function indexes，such as ALT，AST，ALP，TBil and so on，are closely related to the severity of HBC，and can be used as an important biochemical index for HBC diagnosis and disease diagnosis. 2016 Vol. 23 (26): 143-145 [Abstract] ( 133 ) HTML (30 KB)  PDF  (0 KB)  ( 32 ) 146 The predictive results observation of the blood culture results by quantitative detection of serum PCT ZHANG Yan；FENGWen-ke Objective To study the predictive results of blood culture results by quantitative detection on serum PCT. Methods From January 2014 to December 2015，the clinical data of 500 patients for whom were treated in our hospital，at the same time the blood culture and quantitative detection of serum PCT were tested.The clinical data of patients with PCT were detected and the results were effective and retrospectively studied.The results of blood culture and serum PCT in 500 children were tested and analyzed.The sensitivity，specificity，positive predictive value and negative predictive value of PCT in blood culture were analyzed.Results 500 children with blood culture results in 125 cases with positive，including 113 cases of bacterial infection and 12 casesof fungal infection，375 caseswith negative；125 children with positive in PCT detection were showed 108 cases positive，including 97 casesofbacterial infection and 11 cases of fungal infection，the positive predictive valuewas 86.4%，the negative predictive value was 43.47%；using 0.05μg/L as the cut-off value，the sensitivity of PCT on blood culture with 70.25%，specificity with 56.67%，positive predictive value with 28.55%，negative predictive value with 91.56%.Conclusion The quantitative detection of serum PCT can help to diagnose the bloodstream infection in children quickly.If it can be combined with clinical observation and analysis，the detection ratewill improve. 2016 Vol. 23 (26): 146-148 [Abstract] ( 109 ) HTML (30 KB)  PDF  (0 KB)  ( 33 ) 149 Survey analysis on healthy population prevalence and awareness of thyroid nodules JIA Guo-wei；XIEWei；ZHOU Hai-mei；CHEN Guan-chun；XIE Peng Objective To investigate the healthy population prevalence of thyroid nodules.Methods 600 cases of healthy subjectswere randomly selected to enroll to the research in our hospital from June 2015 to May 2016.The prevalence of thyroid nodules in healthy population by color Doppler ultrasound was calculated，and the influence factors of the prevalence of thyroid noduleswas analyzed.Results 194 cases of patientswith positive thyroid noduleswere detected in 600 cases，the positive rate was 32.33%.The detection rate ofmale and female were 29.08%，36.50%；female healthy subjects in thyroid nodules positive ratewas significantly higher thanmale（P＜0.05）.Two age groups（40-49 and 50-59）positive thyroid nodules were the highest detection rate.Thyroid nodules were solid，bilateral sick，single oriented.The positive detection rate of thyroid nodules increased with the increase of BMI，blood glucose and blood pressure，abnormal level of BMIand blood glucose was independent risk factors affecting the positive rate of thyroid nodule detection.The highest proportion of positive patientswere university and college education of patients and medical staff sick.Conclusion The healthy population has a high prevalence of thyroid nodules and low awareness of thyroid nodular disease.Ultrasound and thyroid function do regular inspections，strengthen health education，early detection and diagnosis，follow-up and strengthen the health of patients is of great significance. 2016 Vol. 23 (26): 149-152 [Abstract] ( 129 ) HTML (43 KB)  PDF  (0 KB)  ( 37 ) 153 Analysis on emergency surgical hospitalized children nearly five years characteristics of the disease LIZhe-cheng；WU Zhuo-min Objective To explore the characteristics and disease spectrum of emergency surgical hospitalized children from a Grade-A pediatric hospital.Methods Themedical records of hospitalized children in surgical emergency department from August 2010 to December 2015 were collected and analyzed retrospectively.Results The surgical emergency departmentwas founded since late August 2010，by the end of 2015，total 12 796 children had been treated，amongwhich 9925 were boys，2871 were girls，this ratio was 3.46∶1.Among those treated children，themost common were those children who aged more than 1 year and less than 3 years old（45.2%），the peak treated time was between 23∶00～02∶00，the peak treated month were July and August.The top five disease system was digestive system disease，injury and poisoning，urogenital system disease，congenital malformation，deformation and chromosomal abnormalities，tumor.The sequence of the disease in different gender and age group were different.Conclusion Themost common disease in surgical emergency departmentwere inguinal hernia and intussusception，the peak treated time was between 23∶00～02∶00.Through the study of characteristics and disease spectrum of hospitalized children in surgical emergency department，so as to optimize the resource allocation and focus on trainingmedical staff，therefore to improve the emergency surgical treatment in pediatric. 2016 Vol. 23 (26): 153-155转159 [Abstract] ( 124 ) HTML (36 KB)  PDF  (0 KB)  ( 34 ) 156 Age distribution and regional distribution characteristics of 3367 cases of patientswithgestational diabetesmellitus ZHANG Jing　；XIA Ying-hua Objective To study the number of patientswithgestational diabetesmellitus（GDM）and the incidence ofGDM age distribution characteristics，and the differences of different household register incidence of GDM pregnant women. Methods 28 644 cases of pregnantwomen（including 3367 GDM patients）from January 2014 to June 2016 in our hospital to establish series of prenatalmaternal health card，were retrospectively analyzed.Results GDM patients age was positively skewed distribution，different age，different household register difference were observed in the overall incidence of GDM pregnantwomen reached significant level（P＜0.01），the incidence of a disease（y）and age（x）of the regression equation for y=5 E-05x2.277（18≤x≤45，R2=0.913），age was growed per 1 about a 0.8%increasing in incidence of GDM，different household register incidence of pregnantwomen on the whole was northeast＞coastal＞along the river＞the northwestern，decreased from the trend of the east to the west，along the river to the north and south.Conclusion The incidence of GDM is gradually increased along with the age growth，moderate and GDM nutrition and exercise early pregnant，early intervention is of great significance；according to different regional incidence of GDM and its future trend to strengthen propaganda and education and health way of life to guide on the basis of different strategicmeasures. 2016 Vol. 23 (26): 156-159 [Abstract] ( 151 ) HTML (38 KB)  PDF  (0 KB)  ( 30 ) 160 Effect of policy intervention on clinical antim icrobials use in a Secondclass hospital SUIBai-ling；　JIA Yong　；LIZhi-ping Objective To evaluate the effect of policy intervention on the clinical application of antimicrobial agents in a Second-class hospital.Methods Before and after the implement of"further strengthen the antibacterial drug clinical application management"by the National Health and Family Planning Commission of the P.R.C in August 2015，the evaluation indexes of clinical antimicrobials use in a Second-class hospitalwere compared.Results After the policy intervention，the varieties of antimicrobial drugs decreased from 40 to 32.The antibiotic use rate respectively decreased from 25.0%，45.2%，71.4%to 19.8%，35.6%，58.5%for outpatient，emergency and inpatient（P＜0.05）.The antibacterial use density of inpatient declined from 50.8 DDDs to 39.2 DDDs（P＜0.05）.The antimicrobial prophylaxis of classⅠincision operation corresponded to the standards，the preventivemedication ratio from 38.9%to 29.5%；the percentage of drug treatmentwithin 24 hours from 92.7%to 98.3%；themedication for a reasonable rate from 89.8%to 96.6%；drug selecting reasonable rate from 90.4%to 97.5%（P＜0.05）.The rate of themicrobiological specimen submitted to examination for inpatient increased from 18.5%to 31.5%（P＜0.05）.Conclusion Policy intervention is helpful to the clinical standardized application of antimicrobial agents.The long-term mechanism should be improved in the future in order to further consolidate the results. 2016 Vol. 23 (26): 160-162 [Abstract] ( 128 ) HTML (33 KB)  PDF  (0 KB)  ( 34 ) 163 Statisticalanalysisand safety app lication of easily-confused drugs in western medicine room XIAO Jie-hua Objective To ensure the safety of similar drugs，and to remind the pharmacist to attach importance to similar drugs，reduce allocation errors，promote clinical safety and rational drug use.Methods Chinese medicine and western medicine all the pronunciation and appearance of similar drugs from January to June 2016 in our hospital was classified，and the causeswere analyzed and compared.Easily-confused drug errors caused by the adverse consequenceswere analyzed and prevention of error were given in the reasonable suggestions.Results 51 groups of external packaging and pronunciation or the name of similar drugswere classified and sorted out.Among them，8 groupswere similar in external packaging，43 groups were similar in pronunciation or name.Drugs with similar pronunciation and appearance in our hospitalwere classified and sorted and set up the directory.Conclusion Pharmacistsmust paymore attention to similar drugs in thework，and take preventivemeasures to eliminate the problems caused by drug similar prescription allocation errors，to ensure the safety of patientswithmedication，better service for patients. 2016 Vol. 23 (26): 163-166 [Abstract] ( 115 ) HTML (36 KB)  PDF  (0 KB)  ( 38 ) 167 Practice and experience of Traditional Chinese Medicine Chemistry theory teaching GUO Run-qin；　ZHANG Xiu-ming To satisfy the demand of the current society for the cultivation of traditional Chinesemedicine（TCM）talents，combined with the present teaching situation，the theory teaching of Traditional Chinese Medicine Chemistry is discussed in many ways，such as talking about the first lesson，analogy teachingmethod，stimuational teaching method，case teachingmethod，inductive teachingmethod，multimedia teachingmethod，a students-centered approach and doing exercises.So students′learning interest is stimulated and the teaching quality is improved. 2016 Vol. 23 (26): 167-169 [Abstract] ( 113 ) HTML (33 KB)  PDF  (0 KB)  ( 35 ) 170 Teaching reform and practice on Laboratory diagnostics medicine for eight-year-program medicinemajors WEISan-hua ；DONG Ke ；SHEN Jian-jun ；LIN Fang ；WANG Xi； ZHANG Li-chao ；WU Xi ；ZHANGHui-zhong Laboratory diagnosis medicine lessons for eight-year-porgram medicine majors should be different from five-year-program medicinemajors because of the solid basement，active thinking，a series of teaching reforms should be carried out.Teaching reform has been conducted with organ-system based mode，cases centered on teachingmethod，PBL and bilingual teaching，assisting of clinical visiting，network course，subjectweb and lectures.After the teaching reform，the students can autonomously learn correlated knowledge with higher performance records，the abilities of clinical thinking as well as aggregate analysis and prognosis for disease have been promoted.Significant results have been gained after teaching reformation for eight-year-program medicinemajors，providing practice experience for next reformation of laboratory diagnosismedicine. 2016 Vol. 23 (26): 170-172转176 [Abstract] ( 112 ) HTML (33 KB)  PDF  (0 KB)  ( 28 ) 173 Com parative study of the multidisciplinary team mode and traditional mode in oncology clinical practice teaching HU Ze-cheng ；ZHAO Xiao-chun　；JIANG Hong-yan Objective To observe and compare the effects ofmultidisciplinary team（MDT）mode and traditionalmode in oncology clinical practice teaching.Methods 81 undergraduates in 2010 grade and 91 undergraduates in 2011 grade major in oncology，who had been practiced in the Cancer Center of the First Hospital of University of South China from May 2014 to December 2015，were chosen and taught respectively by MDT mode or traditionalmode in the period of internship.After the internship stage，the students should carried out questionnaires and evaluated their study effect，and then the comparative analysiswasmade.Results The students gave a high praise on the application of MDTmode and this innovation has resulted in a better effect especially.Conclusion MDT model is a better method than traditional mode in oncology practice teaching. 2016 Vol. 23 (26): 173-176 [Abstract] ( 161 ) HTML (35 KB)  PDF  (0 KB)  ( 29 ) 177 Present situation，problem s and thoughts with regard to the training of General Practitioners in China XU Gang-zhu；LIYa-jun；ZHAO Hang；ZHANG Bei General practitioners are"gatekeeper"for the health of residents in health care system，moreover，they also are provider of the basic medical and public health services.Extensive exploration have been applied in general practitioner training by governments，medical university and correlated medical institution everywhere，however general practitioner training status are dissatisfactory yet.The authors investigate the development of general practitioner human resources status and training status nowdays，and analysis the existing problems.Finally，several thoughts and suggestions were proposed. 2016 Vol. 23 (26): 177-179 [Abstract] ( 182 ) HTML (39 KB)  PDF  (0 KB)  ( 36 ) 180 Analysis of effective nursing measures for the successful blood collection of neonatal disease screening LU Chun-hua Objective To explore the effective nursingmeasures to improve the success of blood sampling in neonatal disease screening.Methods 152 newborns from March 2014 to April 2015 in our hospital were randomly divided into control group and observation group.The control group was given routine nursing，observe group was enhanced neonatal blood sampling before and after nursing intervention on the base of routine nursing.The neonates in the two groups through the heel blood collected for disease screening，neonatal blood results and family satisfaction of two groupswere compared.Results Time of blood taking of observation group was shorter than that of the control group，blood spot diameterwas less than thatof controlgroup，and a success rate ofobservation group was93.42%（71/76），higher than thatof control group of 100.00%，the incidence of neonatal red and swollen of observation group was 0.00%，significantly lower than that of control group of 6.58%（5/76），the differencewas significant（P＜0.05），family satisifaction of observation group was better than that of control group，the difference was significant（P＜0.05）.Conclusion It is effective to strengthen the nursing intervention of neonatal disease screening，and has a high clinical value. 2016 Vol. 23 (26): 180-182 [Abstract] ( 157 ) HTML (37 KB)  PDF  (0 KB)  ( 32 ) 183 Effect of com prehensive oral care intervention on prevention of dental caries in children CHEN Qi-qin；GE Feng-hua；XIXiao-ying Objective To explore the clinical effect of comprehensive oral care intervention on the prevention of dental caries in children.Methods 5 kindergartens from January to June 2015 were randomly selected in our city，40 children were randomly selected from every kindergarten，a total of 200 children as the research object，according to the random number table method all children were divided into two groups，each group of 100 cases，the intervention group was given oral comprehensive nursing and the control group used conventional nursing，after intervention measures for a period of time，two groups of children′s dental health were observed and recorded，and for the two groups of children all the study findings and data statisticalwere analyzed and compared.Results Nursing intervention after different time of two groups of children were suffering from dental caries comparison shows thatwere treated 3，6，9 and 12 months，after observed groups of all time suffering from caries number was significantly less than that of control group，the difference significant（P＜0.05）；two groups of children nursing intervention processwith the degree of comparison showed that the observation group had 79 cases of very cooperate，16 cases of general coordination，only 5 cases do notmatch，with the rate of 95.00%，while the control group had 57 cases of very cooperate，7 cases of general coordination，36 cases do notmatch，match rate was 64.00%，two groups was more obvious，there was significant difference（P＜0.05）.Conclusion For the prevention of dental caries in children should take comprehensive oral care intervention，the oral comprehensive nursing intervention can obviously promote the children in the implementation of nursing intervention in the process ofmatch rate，reduce the risk of children suffering from dental caries，to help children develop good oral hygiene habits and pre control of dental caries has positive significance.It isworthy ofwide popularization and application. 2016 Vol. 23 (26): 183-185 [Abstract] ( 116 ) HTML (32 KB)  PDF  (0 KB)  ( 37 ) 186 Value of evidence-based nursing in the app lication of laparoscopic cholecystectom y in patientswith gallbladder stone ZHANG Hong Objective To explore the clinical value of evidence-based nursing in patientswith gallbladder stones.Methods 64 cases of laparoscopic cholecystectomy in our hospital from November 2013 to November 2015 were selected as the target of this study，and were randomly assigned by the envelope.The control group of 32 patients were received general nursing，the experimental group of 32 patientswith the implementation of evidence based nursing.Two groups of patients with gallstone patients undergoing laparoscopic surgery pain lasting time，pain scores，satisfaction score and complications incidence were analyzed and compared.Results Two groups postoperative of pain score on the 1stand 2ndday without significant difference　（P＞0.05）；but between groups after the 3rd，4thand 5thdays of pain score，pain last time，satisfaction scoreswere significantly different（P＜0.01）.In the control group of 32 patientswith the complication rate was 37.50%，which was significantly higher than that of experimental group　（9.38%）（P＜0.01）.Conclusion Evidence based nursing care can effectively reduce the pain of patients，reduce the incidence of complications and improve the patient′s satisfaction. 2016 Vol. 23 (26): 186-188 [Abstract] ( 123 ) HTML (33 KB)  PDF  (0 KB)  ( 29 ) 189 Effects on delivery room early nursing intervention on postpartum urinary retention JIANG Li-ping；　ZENG Hui-fang；　YE Li-hua Objective To explore the delivery room early nursing intervention for prevention of postpartum urinary retention.Methods From May 2014 to May 2016 in our hospital obstetric delivery，the clinical data of 150 cases of maternalwomen were retrospectively analyzed，according to different nursingmethods，they were divided into observation group and control group，75 cases in the observation group were used the delivery room early maternal nursing intervention，75 cases of maternal in the control group were given routine nursing intervention，maternal postpartum urinary retention rate，nursing satisfaction，time of urination，urethral catheterization rate index for the first time of two groups were compared.Results The observation group of maternal postpartum urinary retention rate was significantly lower than that of control group of 5.33%to 17.33%，and the observation group ofmaternal urethral catheterization rate was 1.33%less than 9.33%of the control group（P＜0.05）；observation group ofmaternal urination time was shorter than that of control group for the first time（P＜0.01）.Conclusion The delivery room early nursing intervention can help prevent the occurrence of postpartum urinary retention，promotematernal postpartum urine in time，promote the puerpera restores，it isworthy of popularization and application. 2016 Vol. 23 (26): 189-191 [Abstract] ( 126 ) HTML (32 KB)  PDF  (0 KB)  ( 38 ) 192 Influence of nursing intervention on complications and compliance of patientswith PICC catheter in cancer patients JIN Feng-zhen；　WEN Fu-gang Objective To explore the influence of nursing intervention on the complications and compliance of PICC catheter in cancer patients.Methods 57 cancer patients with PICC catheter from January 2012 to June 2015 in our hospital were chosen and given nursing intervention，statistics of its nursing intervention compliance row PICC catheter and the complication rate for patientswith all care before and after intervention were compared.Results Statistical nursing intervention in all patients after compliance，which was 82.46%of full compliance，partial compliance rate of 14.04%，3.51%of non-compliance.The incidence of complications after nursing was 14.04%，before treatment was 33.33%，the difference was significant（P＜0.05）.Conclusion For cancer patientswith PICC catheter，taking care interventions have a significant effect，patients can achieve a higher compliance，reduce the incidence of complications，for itswidely. 2016 Vol. 23 (26): 192-194 [Abstract] ( 116 ) HTML (30 KB)  PDF  (0 KB)  ( 32 ) 195 App lication of orem self-care mode in postpartum self-care ability after maternal spontaneous vaginal delivery LUO Xu-wen ；CHENG Li Objective To investigate the application effect of Orem self-caremode in postpartum self-care ability after spontaneous vaginal delivery.Methods A total of 162 cases of parturientwomen after vaginal delivery in obstetrics department of our hospital from January 2013 to July 2014 were selected and divided into two groups.The control group （80 cases）were received traditional routine nursing care and the observation group（82 cases）were used Orem self-care mode for nursing instruction.The corresponding nursingwas provided according to different postpartum stages.The exercise of self-care agency（ESCA）and symptom Checklist-90（SCL-90）were used to compare the nursing effect between the two groups.The questionnaire method was used to evaluate the satisfaction degree of nursing effect.Results The self-care ability and SCL-90 score of the observation group were better than than those of control group.The satisfaction degree of nursing in the observation group　（96.34%）was significantly higher than that of control group　（72.50%），with significant difference（P＜0.05）.Conclusion The Orem self-caremode can improve the self-care ability of parturient women after spontaneous vaginal delivery，improve their quality of life，help to build a harmonious relationship between nurses and patients and increase their satisfaction degree of nursing effect. 2016 Vol. 23 (26): 195-197 [Abstract] ( 113 ) HTML (31 KB)  PDF  (0 KB)  ( 25 )

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