慢性结石性胆囊炎与胆囊癌关系的研究进展

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Abstract Gallbladder carcinoma is themost common malignant tumor in biliary system.Themain risk factors are due to prolonged exposure to gallbladder stones.Under the chronic inflammatory environment enabled by the recurrent cycles of gallbladder epithelium damage-repair，which promotesmorphological impairment of gallbladder epithelial cells through the process of"metaplasia and dysplasia and cancer".In this paper，the relationship between chronic calculus cholecystitis and gallbladder carcinoma is reviewed，which provides the research basis for the prevention，early diagnosis and drug treatment of gallbladder carcinoma.

Key words： Gallbladder stones Chronic calculus cholecystitis Cyclooxygenase-2 C reactive protein Liver X receptors Gallbladder carcinoma

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	Articles by authors
	ZOU Rong-ji
	MA Qing-jiu

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ZOU Rong-ji,MA Qing-jiu. Research progress on the relationship between chronic calculus cholecystitis and gallbladder carcinoma[J]. 中国当代医药, 2016, 23(26): 15-18.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I26/15

［26］	中华医学会外科学分会胆道外科学组.胆囊癌诊断和治疗指南（2015版）［J］.中华消化外科杂志，2015，14（11）：881-890.
［27］	董臣.意外胆囊癌治疗的研究进展［J］.中国普通外科杂志，2014，23（2）：236-239.
［1］	Hundal R，Shaffer EA.Gallbladder cancer：epidemiology and outcome［J］.Clin Epidemiol，2014，6（1）：99-109.
［2］	Leitch A.A British Medical Association Lecture on gall stonesand cancerof thegallbladder：an experimentalstudy［J］. Br Med J，1924，2（3324）：451-454.
［3］	Adsay NV.Neoplastic precursors of the gallbladder and extrahepatic biliary system［J］.Gastroenterol Clin North Am，2007，36（4）：889-900.
［4］	Reshetnyak VI.Concept of the pathogenesis and treatment of cholelithiasis［J］.World JHepatol，2012，4（2）：18-34.
［5］	Lavoie B，Nausch B，Zane EA，et al.Disruption of gallbladder smoothmuscle function is an early feature in the development of cholesterol gallstone disease［J］.Neurogastroenterol Motil，2012，24（7）：e313-e324.
［12］	郭润生，史佩东，谢津璧，等.白细胞介素-1β对胆囊癌细胞生长和迁移的影响［J］.中华肝胆外科杂志，2015，21 （12）：821-825.
［15］	Runner GJ，Corwin MT，Siewert B，et al.Gallbladder wall thickening［J］.AJR Am J Roentgenol，2014，202（1）：W1-W 12.
［19］	Ghosh N，Chaki R，Mandal V，et al.COX-2 as a target for cancer chemotherapy［J］.Pharmacol Rep，2010，62（2）：233-244.
［23］	Ehling J，Tacke F.Role of chemokine pathways in hepatobiliary cancer［J］.Cancer Lett，2015，379（2）：173-183.
［6］	Carotti S，Guarino MP，Cicala M，et al.Effect of ursodeoxycholic acid on inflammatory infiltrate in gallbladdermuscle of cholesterol gallstone patients［J］.Neurogastroenterol Motil，2010，22（8）：866-873.
［7］	Miquel JF，Van Der Putten J，Pimentel F，et al.Increased activity in the biliary Con A-binding fraction accounts for the difference in crystallization behavior in bile from Chilean gallstone patients compared with Dutch gallstone patients［J］. Hepatology，2001，33（2）：328-332.
［8］	Wu T，Zhang ZG，Liu B，et al.Gutmicrobiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study［J］.BMC Genomics，2013，14 （1）：669.
［9］	Mukhopadhyay S，Landas SK.Putative precursors of gallbladder dysplasia：a review of 400 routinely resected specimens［J］.Arch Pathol Lab Med，2005，129（3）：386-390.
［10］	Mathur SK，Duhan A，Singh S，et al.Correlation of gallstone characteristics with mucosal changes in gall bladder［J］. Trop Gastroenterol，2012，33（1）：39-44.
［11］	Regalo G，Leutz A.Hacking cell differentiation：transcriptional rerouting in reprogramming，lineage infidelity and metaplasia［J］.EMBOMol Med，2013，5（8）：1154-1164.
［13］	Sakamoto H，Mutoh H，Ido K，et al.A close relationship between intestinalmetaplasia and Cdx2 expression in human gallbladders with cholelithiasis［J］.Hum Pathol，2007，38 （1）：66-71.
［14］	Seretis C，Lagoudianakis E，Gemenetzis G，et al.Metaplastic changes in chronic cholecystitis：implications for early diagnosis and surgical intervention to prevent the gallbladder metaplasia-dysplasia-carcinoma sequence［J］.J Clin Med Res，2014，6（1）：26-29.
［16］	Cheng J，Fan XM.Roleof cyclooxygenase-2 in gastric cancer development and progression［J］.World J Gastroenterol，2013，19（42）：7361-7368.
［17］	Tsujii M.Cyclooxygenase，cancer stem　cells and　DNA methylation play important roles in colorectal carcinogenesis［J］.Digestion，2013，87（1）：12-16.
［18］	Legan M.Cyclooxygenase-2，p53 and glucose transporter-1 as predictors of malignancy in the development of gallbladder carcinomas［J］.Bosn JBasic Med Sci，2010，10（3）：192-196.
［20］	Liu E，Sakoda LC，Gao YT，et al.Aspirin use and risk of biliary tract cancer：a population-based study in Shanghai，China［J］.Cancer Epidemiol Biomarkers Prev，2005，14 （5）：1315-1318.
［21］	Aleksandrova K，Boeing H，Nöthlings U，et al.Inflammatory and metabolic biomark ers and risk of liver and biliary tract cancer［J］.Hepatology，2014，60（3）：858-871.
［22］	Kemp TJ，Castro FA，Gao YT，et al.Application of multiplex arrays for cytokine and chemokine profiling of bile［J］. Cytokine，2015，73（1）：84-90.
［24］	Steffensen KR，Jakobsson T，Gustafsson JA°.Targeting liver X receptors in inflammation［J］.Expert Opin Ther Targets，2013，17（8）：977-990.
［25］	Gabbi C，Kim HJ，Barros R，et al.Estrogen-dependent gallbladder carcinogenesis in LXRbeta-/-femalemice［J］.Proc Natl Acad Sci USA，2010，107（33）：14763-14768.