Clinical effect of Metformin combined with Sitagliptin in the treatment of patients with type 2 diabetes
LI Qiong1 FAN Jun-xiu1 PENG Wei1 PANG Dong-yue2 HU Jing-jing2 ZHANG Li-zhi2▲
1.Department of Medical Laboratory,Ji′an Hospital,Shanghai Oriental Hospital,Jiangxi Province,Ji′an 343000,China;
2.Department of Endocrinology,Jiangqiao Hospital in Jiading District,Jiading Branch of the First People′s Hospital of Shanghai City,Shanghai 201803,China
Abstract:Objective To investigate the clinical effect of Metformin combined with Sitagliptin in the treatment of patients with type 2 diabetes.Methods A total of 105 patients with type 2 diabetes who were treated in Shanghai Oriental Hospital from January 2017 to July 2020 who treated with Metformin alone and had poor glucose control effects were selected as the research objects.Among them,5 cases fell out,and 100 cases were finally enrolled.They were divided into group A(30 cases),group B(35 cases)and group C(35 cases)by random number table.Patients in group A continued to be treated with Metformin,patients in group B were treated with Metformin combined with Acarbose.Patients in group C were treated with Metformin combined with Sitagliptin.1,5-dehydroglucositol(1,5-AG),glycated hemoglobin(HbA1c),blood glucose ratio time within the target range(TIR)and the incidence of adverse reactions in three groups were compared before and after treatment.Results After intervention,the level of 1,5-AG in groups B and C were higher than that in group A at different visit periods,and the differences were statistically significant(P<0.05).The 1,5-AG in group C was higher than that in group B,and the difference was statistically significant(P<0.05).After intervention,HbA1c in group B and C were lower than group A,and the differences were statistically significant(P<0.01).After intervention,there was no significant difference in HbA1c between group B and C(P>0.05).After intervention,TIR of group B and C were higher than that of group A,and the differences were statistically significant(P<0.01).After intervention,TIR in group C was higher than that in group B,and the difference was statistically significant(P<0.01).The total incidence of adverse reactions in group A and C were lower than that in group B,and the differences were statistically significant(P<0.05).There was no statistical significance in the total incidence of adverse reactions between group A and C(P>0.05).Conclusion The combination of Metformin and Sitagliptin can significantly reduce HbA1c,and the patient′s blood glucose fluctuations will be smaller.It is a more optimized hypoglycemic treatment.
李琼;范军秀;彭卫;庞东岳;胡晶晶;张莉芝▲. 二甲双胍联合西格列汀治疗2型糖尿病患者的临床效果[J]. 中国当代医药, 2021, 28(17): 59-63.
LI Qiong;FAN Jun-xiu; PENG Wei; PANG Dong-yue;HU Jing-jing;ZHANG Li-zhi▲. Clinical effect of Metformin combined with Sitagliptin in the treatment of patients with type 2 diabetes. 中国当代医药, 2021, 28(17): 59-63.
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