Clinical effect of Fuzheng Huazhuo Decoction in the treatment of elderly patients with drug-resistant bacteria pneumonia qi deficiency phlegm turbidity obstructing lung syndrome
GAO Yuan1 LIU Hao1▲ MU Xiao-jing1 QU Ni-ni2 QIN Yi-bing3
1.Department of Critical Care,Dalian Traditional Chinese Medicine Hospital,Liaoning Province,Dalian 116013,China;
2.Department of Respiratory,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Province,Shenyang 110032,China;
3.Graduate School,Liaoning University of Traditional Chinese Medicine,Liaoning Province,Shenyang 110032,China
Abstract：Objective To explore the clinical effect of Fuzheng Huazhuo Decoction in the treatment of elderly patients with drug-resistant bacteria pneumonia qi deficiency phlegm turbidity obstructing lung syndrome.Methods A total of 60 elderly patients with drug-resistant pneumonia (qi deficiency phlegm turbidity obstructing lung syndrome) admitted to Dalian Traditional Chinese Medicine Hospital from October 2017 to May 2019 were selected as the research objects and divided into the treatment group and the control group according to random number table method,with 30 cases in each group.The control group was treated by routine western medicine treatment,and the treatment group was treated by Fuzheng Huazhuo Decoction on the basis of the treatment of the control group.After treatment,the antibiotic resistance bacteria clearance rate,clinical pulmonary infection score (CPIS),inflammatory indicators (tumor necrosis factor-α[TNF-α],high mobility group box 1 protein[HMBG-1],and interleukin-10[IL-10])were compared between the two groups.Results There was no statistically significant difference in the clearance rate of drug-resistant bacteria between the two groups (P＞0.05).The clinical pulmonary infection score(CPIS) of the treatment group was lower than that of the control group,and the difference was statistically significant (P＜0.05).The serum levels of TNF-α and HMBG-1 in the treatment group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The serum level of IL-10 in the treatment group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The anti-infective effect of the treatment of elderly drugresistant bacteria pneumonia qi deficiency phlegm turbidity obstructing lung syndrome with Fuzheng Huazhuo Decoction on the basis of the conventional western medicine,and it has a positive and effective role in clearing inflammatory mediators.
Ho J，Ip M.Antibiotic-Resistant Community-Acquired Bacterial Pneumonia[J].Infect Dis Clin North Am，2019，33（4）：1087-1103.
[6]
葛均波，徐永健，王辰.内科学[M].9版.北京：人民卫生出版社，2018：42.
[2]
Schll N，Rohde GGU.Ambulant erworbene Pneumonie bei a lteren Menschen [Community-acquired Pneumonia in the Elderly][J].Pneumologie，2019，73（10）：605-616.
[3]
Xu Z，Gu Y，Li J，et al.Dysphagia and aspiration pneumonia in elderly hospitalization stroke patients：Risk factors,cerebral infarction area comparison[J].J Back Musculoskelet Rehabil，2019，32（1）：85-91.
[4]
Vellas C，Delobel P，de Souto Barreto P，et al.COVID-19，Virology and Geroscience：A Perspective[J].J Nutr Health Aging，2020，24（7）：685-691.
[5]
Gidal A，Barnett S.Risk Factors Associated With Multidrug-Resistant Pneumonia in Nonhospitalized Patients[J].Fed Pract，2018，35（1）：16-18.
Samanta J，Singh S，Arora S，et al.Cytokine profile in prediction of acute lung injury in patients with acute pancreatitis[J].Pancreatology，2018，18（8）：878-884.
京公网安备 11010502046607号