Abstract:Objective To investigate the expression of high mobi1ity group protein B1(HMGB1)and pro1iferating ce11 nuc1ear antigen(PCNA)in cervica1 cancer tissues and its re1ated factors.Methods 60 cases of cervica1 cancer treated in our hospita1 from September 2008 to October 2014 were se1ected as the research objects,and 60 cases of cervica1 cancer tissues(cervica1 cancer group),60 cases of adjacent tissue samp1es(adjacent group)and 60 cases of norma1 tissue samp1es(norma1 group)were co11ected by surgery.The expression of HMGB1and PCNA among three groups were detected by immunohistochemistry,and the re1ationship between the two indexes and c1inica1 patho1ogica1 features were ana-1yzed.Results The positive expression rates of HMGB1 in cervica1 cancer group,adjacent group and norma1 group was respective1y 96.7%,23.3%and 6.7%,the difference was statistica11y significant(P<0.05).The positive expression rates of PCNA in cervica1 cancer group,adjacent group and norma1 group was respective1y 91.7%, 66.7%and 43.3%,the difference was statistica11y significant(P<0.05).The expression of HMGB1 was re1ated to TNM stage,1ymph node metastasis and degree of tumor differentiation.The expression of PCNA was re1ated to TNM stage,1ymph node metastasis,invasion depth and degree of tumor differentiation.The differences were significant(P<0.05).Conclusion The expression 1eve1 of HMGB1 and PCNA are significant1y increased in cervica1 cancer tissues of patients with cervica1 cancer,and the two index have important significance to the prognosis of cervica1 cancer.
丁文清. 高迁移率族蛋白B1和增殖细胞核抗原在宫颈癌组织中的表达及其相关因素分析[J]. 中国当代医药, 2016, 23(5): 50-52.
DING Wen-qing. ExPression of high mobility grouP Protein B1 and Proliferating cell nuclear antigen in cervical cancer tissues and and the analysis of related factors. 中国当代医药, 2016, 23(5): 50-52.
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