1.Department of Pathology,Kaiping Center Hospital in Guangdong Province,Kaiping 529300,China;
2.Recovery unit,Kaiping Center Hospital in Guangdong Province,Kaiping 529300,China;
3.Department of Obstetrics and gynecology,Kaiping Center Hospital in Guangdong Province,Kaiping 529300,China;
4.Department of Laboratory,Kaiping Center Hospital in Guangdong Province,Kaiping 529300,China
摘要目的研究液基细胞学筛查（TCT）联合人乳头瘤病毒DNA检测（HPV-DNA）在宫颈癌患者筛查和癌前病变诊断中的意义。方法选取2014年9月～2016年9月来我院进行宫颈癌筛查、妇科宫颈癌检查的330名患者作为研究对象，对患者进行阴道镜及病理组织检查。将患者随机平均分为三组，每组各110例。对A组患者进行TCT检查，B组患者进行HPV检查，C组患者进行TCT联合HPV检查。将三种检测方法进行比较。结果A组（TCT）结果与阴道镜病理组织结果比较，差异有统计学意义（P＜0.05）。B组（HPV-DNA检查）的结果与阴道镜病理组织结果比较，病变程度越高，患者阳性率越高，差异有统计学意义（P＜0.05）。C组（TCT+HPV检测）检测不典型鳞状细胞（ASC），低度鳞状上皮内病变（LSIL），高度鳞状上皮内病变（HSIL）的特异度、灵敏度、准确度高于 A 组（TCT）、B组（HPV检测），差异有统计学意义（P＜0.05）。结论液基细胞学筛查联合人乳头瘤病毒DNA检查是有效筛查、诊断宫颈癌的检查手段，且联合检查的特异度、准确度、灵敏度较高，是临床上值得大力推广和应用的诊断方法。
Abstract：ObjectiveTo study the significance of thinprepcytologic test(TCT)combined with human papillomavirus DNA detection (HPV-DNA)in the diagnosis of cervical cancer and the diagnosis of precancerous lesions.MethodsFrom September 2014 to September 2016,330 patients who have been done cervical cancer screening and gynecological cervical cancer in our hospital were selected as the subjects.The patients were examined by colposcopy and histopathological examination.And the patients were randomly divided into three groups,with 110 cases in each group.The patients of group A were conducted with TCT examination.Group B were conducted with HPV examination and group C were conducted with TCT HPV examination.The advantages and disadvantages of the three different detection methods were compared.ResultsCompared with colposcopy and histopathological examinations,the results of group A(TCT)were different and the differences were statistically significant(P＜0.05).The results of group B(HPV)were significantly higher than those of colposcopy and histopathological exams(P＜0.05).The sensitivity,accuracy and specificity of group C(TCT+HPV)in atypical squamous cell(ASC),low grade squamous intraepithelial lesion(LSIL)and high grade squamous intraepithelial lesion(HSIL)were higher than that in group A(TCT)and group B(HPV),with significant difference(P＜0.05).ConclusionThinprepcytologic test combined with human papillomavirus DNA screening is an effective screening method for the diagnosis of cervical cancer.Because of the higher specificity,accuracy and sensitivity,it is clinically worthy of popularization and application of diagnostic methods.
张朝清;刘丽;吴定滨;邓传芳;许锦文;潘永康;李丽晖;温霭慈. TCT联合HPV检查在宫颈癌患者筛查和诊断中的意义[J]. 中国当代医药, 2018, 25(6): 99-101.
ZHANG Chao-qing;LIU Li;WU Ding-bin;DENG Chuan-fang;XU Jin-wen;PAN Yong-kang;LI Li-hui;WEN Ai-ci. The significance of thinprepcytologic test combined with human papillomavirus DNA screening in the screening and diagnosis of cervical cancer. 中国当代医药, 2018, 25(6): 99-101.
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