Abstract：ObjectiveTo investigate the correlation between the expression of Gab2 in cervical cancer tissue and the clinical pathological features.Methods80 cervical cancer specimens definitely diagnosed by pathology from January 2012 to December 2013 and 20 normal cervical tissue specimens which were stored in our Department of Pathology were randomly selected in our hospital.The immunohistochemical method was used to detect the expression of Gab2 in cervical cancer tissues and normal cervical tissues,and was statistically analyzed together with the clinical and pathological data.ResultsThe positive expression rate of Gab2 in 80 cervical cancer tissues was 58.75% (47/80),and in the 20 normal cervical tissues,only 3 cases were presented with weak positive expression.The rate of positive expression was 0%,which was displayed a statistical difference (P＜0.05).The expression level of Gab2 protein in cervical cancer tissues was positively correlated with lymph node metastasis(P＜0.05),but didn’t present with great correlation with age,size of tumor,histological grading or FIGO stage(P＞0.05).The recurrence and metastasis rate in patients with high Gab2 expression was significantly higher than that of low expression of Gab2(P=0.001).ConclusionGab2 may play an important role in the occurrence and progression of cervical cancer,and may be considered as a potential for prognostic marker of cervical cancer.
Chen W，Zheng R，Baade PD，et al.Cancer statistics in China，2015[J].CA Cancer J Clin，2016，66（2）：115-132.
[2]
Pan XL，Ren RJ，Wang G，et al.The Gab2 in signal transduction and its potential role in the pathogenesis of Alzheimer′s disease[J].Neurosci Bull，2010，26（3）：241-246.
[3]
Xu XL，Wang X，Chen ZL，et al.Overexpression of Grb2 associated binder 2 in human lung cancer[J].Int J Biol Sci，2011，7（5）：496-504.
[4]
Bocanegra M，Bergamaschi A，Kim YH，et al.Focal amplification and oncogene dependency of GAB2 in breast cancer[J].Oncogene，2010，29（6）：774-779.
[5]
Ding C，Luo J，Yu W，et al.Gab2 is a novel prognostic factor for colorectal cancer patients[J].Int J Clin Exp Pathol，2015，8（3）：2779-2786.
[6]
Addams SJ，Aydin IT，Celebi JT.GAB2-ascaffolding protein in cancer[J].Mol Cancer Res，2012，10（10）：1265-1270.
[7]
Ke Y，Wu D，Princen F，et al.Role of Gab2 in mammary tumorigenesis and metastasis[J].Oncogene，2007，26（4）：4951-4960.
[8]
Wohrle FU，Daly RJ，Brummer T.Function regulation and pathological roles of the Gab/DOS docking proteins[J].Cell Commun Singnal，2009，7（1）：1186-1214.
[9]
Nishida K，Hirano T.The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors[J].Cancer Sci，2003，94（12）：1029-1033.
[10]
Maus M，Medgyesi D，Kvesdi D，et al.Grb2 associated binder 2 couples B cell receptor to cell survival[J].Cell Signal，2009，21（2）：220-227.
[11]
Ding CB，Yu WN，Feng JH，et al.Structure and function of Gab2 and its role in cancer （Review）[J].Mol Med Rep，2015，12（3）：4007-4014.
[12]
Zatkova A，Schoch C，Speleman F，et al.GAB2 is a novel target of 11q amplification in AML/MDS[J].Genes Chromosomes Cancer，2006，45（9）：798-807.
[13]
Wang Y，Sheng Q，Spillman MA，et al.Gab2 regulates the migratory behaviors and E-cadherin expression via activation of the PI3K pathway in ovarian cancer cells[J].Oncogene，2012，31（20）：2512-2520.
[14]
Lee SH，Jeong EG，Nam SW，et al.Increased expression of Gab2，a scaffolding adaptor of the tyrosine kinase signalling，in gastric carcinomas[J].Pathology，2007，39（3）：326-329.
[15]
Chermoff KA，Bordone L，Horst B，et al.GAB2 amplifications refine molecular classification of melanoma[J].Clin Cancer Res，2009，15（13）：4288-4291.
[16]
Shi L，Sun X，Zhang J，et al.Gab2 expression in glioma and its implications for tumor invasion[J].Acta Oncol，2013，52（8）：1739-1750.
[17]
Bentires-Alj M，Gil SG，Chan R，et al.A role for the scaffolding adapter GAB2 in breast cancer[J].Nat Med，2006，12（1）：114-121.
京公网安备 11010502046607号