Expression and significance of S100A8/A9 and S100A4 in vulvar sclerosing mosses
CHEN Xiao-dan1 MENG Fei1 WU Xin2▲
1.Department of Obstetrics,Central Hospital Affiliated to Shenyang Medical College,Liaoning Province,Shenyang 110024,China;
2.Department of Gynaecology,the First Affiliated Hospital of China Medical University,Liaoning Province,Shenyang 110001,China
Abstract：Objective To detect the expression of S100A8/A9 and S100A4 in vulvar sclerosing mosses,and to explore the relationships between S100A8/A9,S100A4 and vulvar sclerosing mosses.Methods Thirty surgical specimens were collected from the Department of Gynecology of the First Affiliated Hospital of China Medical University from January 2008 to January 2018 in patients with vulvar sclerosing mosses.The normal vulva skin samples of 10 patients who needed vaginal surgery such as uterine prolapse from January 2013 to January 2018 were selected from the Gynecological Ward of the First Affiliated Hospital of China Medical University.The samples were detected by SABC immunohistochemistry.The expression of S100A8/A9 and S100A4 were analyzed.Results In normal skin of vulva,S100A8/A9 positive cells were mostly located in basal cell layer,and the optical density of S100A8/A9 positive cells was 0.7946±0.1369.However,in vulvar sclerosing mosses,S100A8/A9 positive cells were mostly located near the whole layer of epidermis,and the optical density of S100A8/A9 positive cells was 1.6206±0.4312.The optical density of S100A8/A9 positive cells in vulvar sclerosing mosses was higher than that in normal vulva skin,and the difference was statistically significant (P<0.05).In normal skin of vulva,S100A4 positive cells were mostly located in basal cell layer,and a small amount of stromal cells were positively expressed in dermis.The optical density of S100A4 positive cells was 0.3020±0.1266.However,in mosses sclerosing vulva,S100A4 positive cells were still located in the basal layer and were negatively expressed in the interstitium.The optical density of S100A4 positive cells was 0.3583±0.1575.There was no significant difference in the optical density of S100A4 positive cells between mosses sclerosing vulva and normal vulva skin samples (P>0.05).Conclusion S100A8/A9 take a part in the pathological process of vulvar sclerosing mosses,however S100A4 may not have definite correlation with the pathological process of vulvar sclerosing mosses.
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