Abstract：Objective To investigate the expression and clinical significance of p140Cap in breast cancer.Methods A total of 246 cases of primary breast cancer from June 2012 to June 2017 in our hospital were selected as the case group,and 60 cases of adjacent tissues of breast cancer were selected as the control group.Immunohistochemical technique was used to detect the expression levels of p140Cap gene in the two groups.The expression levels of p140Cap gene in breast cancer and normal breast tissue,the expression levels and correlation of different molecular classifications of breast cancer and in different clinical parameters were analyzed by statistical method.Results The expression of p140Cap was significantly decreased or absent in breast cancer tissues,and which was significantly different from that in para-carcinoma tissues(P＜0.05).The expression of p140Cap was related with the tumor diameter,age,axillary lymph node metastasis,histological grading,estrogen receptor status,progesterone receptor status,and human epidermal growth factor receptor status,but not to tumor stage.Conclusion p140Cap is lowly expressed in breast cancer tissues and correlates with clinicopathological types of breast cancers in some prognosis,which affects the poor prognosis of breast cancer.
童辉. p140Cap在乳腺癌中的表达及其临床意义[J]. 中国当代医药, 2018, 25(29): 52-54.
TONG Hui. Expression of p140Cap in breast cancer and its clinical significance. 中国当代医药, 2018, 25(29): 52-54.
Sato H，Suzu ki H，Toyota M，et al.Frequent epigenetie in a ctivation of p140Cap genes in human gastros in testinal tumors[J].Carcinogenesis，2007，28（12）：2459-2466.
[2]
Stanley R，Hamihnn Lauri A.Wodd Heahh Organization classificatio tumours pathology and genetics of tumours of the digestive system[J].IARC Press，2000，20（10）：103-142.
[3]
Bretthauer M.Colorectal cancer screening[J].Intern Med，2011，270（2）：87-90.
[4]
Christofori G.New signals from the invasive front[J].Nature，2006，8（5）：444-450.
Ito H，Atsuzawa K，Sudo K，et al.Characterization of a multidomain adaptor protein p140Cap as part of a pre-synaptic complex[J].J Neurochem，2008，107（1）：61-72.
[7]
Thiery JP.Epithelial-mesenchymal transitions in tumour progression[J].Nat Rev Cancer，2002，2（6）：442-454.
[8]
Giancotti FG.A structural view of integrin activation and sinaling[J].Dev cell，2003，4（2）：149-151.
[9]
Damiano L，Di Stefano P,Camacho L，et al.P140cap dual regulation of E-cadherin/EGFR cross-talk and Ras signaling in tumour cell scatter and proliferation[J].Oncogene，2010，29（25）：3677-3690.
Cavallaro U，Christofori G.Cell adhesion and signalling by cadherins and Ig-CAMs in cancer[J].Nat Rev Cancer，2015，4（1）：118-132.
[12]
张梦南.p140Cap在大肠癌恶性生物学表型中的作用[D].广州：广州医科大学，2015.
[13]
Sharma N，Repetto D，Aramu S，et al.Identification of two regions in the p140Cap adaptor protein that retain the ability to suppress tumor cell properties[J].Am J Cancer Res，2013,3（3）：290-301.
[14]
Russo I，Gavello D，Menna E，et al.p140Cap regulates gabaergic synaptogenesis and development of hippocampal inhibitory circuits[J].Cereb Cortex，2017，27（11）：1-15.
[15]
Grasso S，Chapelle J，Salemme V，et al.Author Correction:The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries[J].Nat Commun，2018，9：16 203.
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