Abstract：Objective To investigate the effect of prone position ventilation for severe acute respiratory distress syndrome (ARDS).Methods A total of 48 patients with severe ARDS who were admitted to our Intensive Care Unit from June 2015 to August 2017 were selected.By a random number table method,they were equally divided into groups A and groups B.Another batch of 24 mild to moderate ARDS was selected as group C.Patients in group A and C were treated with prone position ventilation,while in group B,patients were treated with supine position ventilation.Hemodynamic parameters including heart rate (HR),cardiac index (CI),central venous pressure (CVP)and mean arterial pressure(MAP)between the groups A and B were compared.The levels of oxygenation index before and after treatment among the three groups were compared.The incidence of adverse events and prognostic indicators such as time of ICU stay and mechanical ventilation time within 28 days between the groups A and B were compared.Results After treatment,there was no significant difference in HR,CI,CVP or MAP between the groups A and B(P＞0.05）.After treatment,the oxygenation index of group A was lower than that of group C,but higher than that of group B(P＜0.05）.The oxygenation index of group B was lower than that of group C with a significant difference(P＜0.05）.The total incidence of adverse events in group A was lower than that in group B with a significant difference (P＜0.05）.The ICU stay in group A and mechanical ventilation time within 28 days were both shorter compared with those in group B with statistical significance (P＜0.05）.Conclusion For patients with severe ARDS,prone position ventilation can improve the oxygenation,reduce adverse events,shorten mechanical ventilation time,speed up symptom relief,and enhance therapeutic efficacy.
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