Abstract：Objective To explore the effects of airway pressure release ventilation(APRV)and lung protective ventilation(SIMV)on acute respiratory distress syndrome.Methods 94 patients with acute respiratory distress syndrome admitted to our hospital from November 2016 to November 2017 were selected as the research subject,and were divided into two groups(n=47)according to the random number table method.Pulmonary protective ventilation was performed in the SIMV group and airway pressure release ventilation was applied in the APRV group.The arterial blood gas index,airway mechanics,hemodynamics and lung injury were compared between the two groups before ventilation and 2 days after ventilation.Results There was no significant difference in PaO2/FiO2,ELWI,Ppeak and Pmean between the two groups before ventilation (P＞0.05).After ventilation,however,the PaO2/FiO2in the SIMV group was shown to be lower than that in the APRV group,while the ELWI,Ppeak and Pmean were higher than that in the APRV group,the differences were statistically significant(P＜0.05).There was no significant difference in HR,CVP,MAP and Murray score between the two groups before ventilation(P＞0.05).After 2 days of ventilation,the HRV,CVP and Murray scores in the SIMV group were shown to be higher than those in the APRV group,and the MAP was lower than that in the APRV group,the differences were statistically significant(P＜0.05).Conclusion Compared with SIMV,APRV is more effective in the treatment of patients with acute respiratory distress syndrome,which is beneficial to their respiratory function and lung recruitment.It can also improve the hemodynamics of the patients and is better for their recovery.
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