Abstract：Objective To investigate the influence of combined spinal-epidural anesthesia (CSEA)on stress response and hemodynamics in senile patients with orthopedic surgery.Methods 100 senile patients with fracture received surgery in our hospital from February 2015 to February 2016 were selected as the research object,and they were divided into the observation group and the control group according to random number table method,50 cases in each group.The patients in control group was given general anesthesia,while the patients in observation group was given CSEA.The stress response and changes of hemodynamic indexes were compared between the two groups.Results The epinephrine,angiotensin,renin,norepinephrine in the observation group was lower than that in the control group,with statistical difference(P＜0.05).Before the anesthesia,the level of DBP,SBP,HR between the two groups were compared,there was no statistical difference(P＞0.05).After the anesthesia for 10 min and 30 min,the levels of DBP,SBP,HR in the two groups significantly decreased compared with those before anesthesia,and the descend speed of the control group was more quicker,with statistical difference (P＜0.05).Conclusion CSEA in senile patients with orthopedic surgery is effective,it can reduce stress response and improve indexes of hemodynamics,which is worthy of clinical application.
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