ObjectiveTo investigate and analyze the clinical significance of fibrinogen(FIB)and D-dimer(D-D)in the detection of deep venous thrombosis after lower limb fracture in elderly patients.Methods60 cases of elderly patients who.receivedlower limb fracture surgery in our hospital from March,2016 to March,2017 were randomly divided into the observation group,other 60 cases of healthy subjects were divided into the control group.Then,the levels of FIB and D-D were compared between the two groups,and the patients in the observation group were divided into DVT group of 8 cases and non DVT group of 52 cases according to color Doppler ultrasound results in the same time.And the levels of FIB and D-D were compared between the two groups.ResultsThe levels of FIB and D-D in the observation group were significantly higher than those in the control group(P＜0.05).There was no significant difference in FIB and D-D levels between DVT group and non-DVT group before operation(P＜0.05),while the levels of various indexes in DVT group after operation were significantly higher than those in non-DVT group(P＜0.05).ConclusionThe FIB and D-D are sensitive markers in detecting deep venous thrombosis after lower limb fracture in elderly patients,and it is great significance for prevention and treatment of deep vein thrombosis in elderly patients with lower limb fracture.
杨冬文 ;林少胜; 蔡伟俊. 检测纤维蛋白原和D-二聚体对老年人下肢骨折术后并发深静脉血栓的临床意义[J]. 中国当代医药, 2018, 25(6): 105-107.
YANG Dong-wen; LIN Shao-sheng;CAI Wei-jun. Clinical significance of fibrinogen and D-dimer in the detection of deep venous thrombosis after lower limb fracture in elderly patients. 中国当代医药, 2018, 25(6): 105-107.
Shih L，Kaplan D，Kraiss LW，et al.Enhanced Platelet-Monocyte aggregate Formation is Associated with Post-Surgical deep vein thrombosis in older patients undergoing elective orthopedic surgery[J].Vascular Medicine，2015，20（3）：298-299.
[5]
Wypasek E，Potaczek DP，Alhenc-Gelas M，et al.Heerlen polymorphism associated with typeⅢprotein S deficiency and factor V Leiden mutation in a Polish patient with deep vein thrombosis[J].Blood coagul：Fibrindysis，2014，25（1）：84-85.
[8]
Chung WS，Lin CL，Sung FC，et al.Increased risks of deep vein thrombosis and pulmonary embolism in sjg rensyndrome：a Nationwide cohort study[J].J Rheumatol，2014，41（5）：909-915.
京公网安备 11010502046607号