Abstract：Objective To investigate the effect of Irinotecan combined with Cisplatin neoadjuvant chemotherapy on serum levels of folic acid,squamous cell carcinoma associated antigen (SCC-AG) and carbohydrate antigen 125 (CA125)in patients with locally advanced cervical cancer.Methods A total of 110 patients with locally advanced cervical cancer who were admitted to Egang Hospital from January 2016 to January 2019 were selected as the research subjects.According to the treatment method,they were divided into control group (55 cases) and observation group (55 cases).The control group was treated with concurrent chemoradiotherapy before total uterine resection,and the observation group was treated with Irinotecan combined with Cisplatin neoadjuvant chemotherapy before total uterine resection.The total effective rate of treatment,the total incidence of adverse reactions and serum folic acid,SCC-Ag and CA125 levels before and after treatment were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).After treatment,the serum folate level in the observation group was higher than that before treatment,and the serum folate level in the observation group was higher than that in the control group,the differences were statistically significant (P＜0.05).After treatment,the levels of SCC-Ag and CA125 in the observation group were lower than those before treatment,and the levels of SCC-Ag and CA125 in the observation group were lower than those in the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups (P＞0.05).Conclusion The treatment of Irinotecan combined with Cisplatin neoadjuvant chemotherapy is more effective than concurrent chemoradiotherapy in the treatment of with patients locally advanced cervical cancer.It can significantly reduce the levels of SCC-Ag and CA125,increase serum levels of folic acid,without increasing the incidence of adverse drug reactions.
Denny L，Adewole I，Anorlu R，et al.Human papillomavirus prevalence and type distribution in invasive cervical cancer in sub-Saharan Africa[J].Int J Cancer，2014，134（6）：1389-1398.
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