Clinical effect of Magnesium Valproate combined with whole course nursing on improving symptoms, oxidative stress and inflammatory indicators in patients with bipolar disorder
LIN Li-qiu
Psych Ward, Meizhou Third People′s Hospital, Guangdong Province, Meizhou 514089, China
Abstract：Objective To explore the clinical effect of Magnesium Valproate combined with whole course nursing on improving symptoms and related indicators of bipolar disorder patients.Methods Ninety patients with bipolar disorder admitted to our hospital from September 2015 to September 2017 were randomly divided into observation group and control group, 45 cases in each group.Patients in the control group were treated with Lithium Carbonate combined with whole-course nursing, while patients in the observation group were treated with Magnesium Valproate combined with whole-course nursing.The clinical effects of the two groups were compared.Hamilton depression scale(HAMD)was used to evaluate and compare the degree of depression before and after treatment.Mania scale (BRMS) was used to evaluate and compare the degree of mania before and after treatment.The levels of antioxidant indexes (total bilirubin [TBIL],serum albumin [ALB]), inflammatory factors (TNF-a, interleukin-1 [IL-1], interleukin-10 [IL-10]) and adverse reactions were compared between the two groups.Results There was no significant difference in the total effective rate between the two groups (P>0.05).The scores of HAMD and BRMS in the observation group after treatment were significantly lower than those in the control group, the differences were significant (P<0.05).The levels of ALB and TBIL in the observation group were significantly higher than those in the control group, the differences were statistically significant (P<0.05).The levels of TNF-α and IL-1 in the observation group were lower than those in the control group, and the levels of IL-10 were higher than those in the control group, the differences were statistically significant (P<0.05).Conclusion Magnesium Valproate combined with whole-course nursing has a better effect in improving the symptoms,oxidative stress and inflammatory factors of patients with bipolar disorder, and has positive clinical significance for the improvement of patients′ condition and health recovery.
林利秋. 丙戊酸镁联合全程护理改善双相情感障碍患者症状及氧化应激、炎性指标的临床效果[J]. 中国当代医药, 2019, 26(15): 216-219.
LIN Li-qiu. Clinical effect of Magnesium Valproate combined with whole course nursing on improving symptoms, oxidative stress and inflammatory indicators in patients with bipolar disorder. 中国当代医药, 2019, 26(15): 216-219.
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