2型糖尿病肾病与血糖波动及氧化应激水平的相关性分析

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摘要目的探讨2型糖尿病肾病与血糖波动及氧化应激水平的相关性。方法选取2015年1月～2017年12月在我院就诊的90 例2型糖尿病患者作为研究对象，根据24 h 尿微量清蛋白（UAlb）测定结果，分为正常UAlb 组（43 例）和高UAlb 组（47 例）。记录两组患者的一般临床资料以及血糖、血脂等生化指标，并检测氧化应激指标超氧化物歧化酶（SOD）、丙二醛（MDA）水平，完善7 段自我血糖监测，计算血糖水平标准差（SDBG）。结果两组患者的空腹血糖（FBG）、糖化血红蛋白（HbA1c）、收缩压、舒张压、病程、SDBG、SOD、MDA、UAlb 比较，差异均有统计学意义（P＜0.05）；相关分析结果显示，2型糖尿病患者的UAlb 与病程、SDBG、MDA 成正相关（r=0.298、0.435、0.673，P＜0.05）；UAlb 与SOD 成负相关（r=-0.716，P＜0.05）；SOD 与SDBG 成负相关（r=-0.294，P＜0.05）；MDA 与SDBG 成正相关（r=0.282，P＜0.05）。结论糖尿病病程、血糖波动、氧化应激水平与糖尿病肾病的发生发展具有相关性。

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	范玲燕
	卢雪玲

关键词 ： 2型糖尿病肾病, 血糖波动, 氧化应激

Abstract：Objective To explore the correlation between type 2 diabetic nephropathy and blood glucose fluctuation and oxidative stress. Methods A total of 90 patients with type 2 diabetes who were admitted to our hospital from January 2015 to December 2017 were selected. According to the 24-hour urine microalbumin (UAlb) determination results, they were divided into the normal UAlb group (43 cases) and the high UAlb group (47 cases). General clinical data, blood glucose, blood lipid and other biochemical indicators of patients in the 2 groups were recorded, and the levels of oxidative stress index superoxide dismutase (SOD) and malondialdehyde (MDA) were detected. The seven-stage self-monitoring of blood glucose was improved, and the standard deviation of blood glucose level (SDBG) was calculated. Results Fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), systolic blood pressure, diastolic blood pressure, course of diabetes, SDBG, SOD, MDA, and UAlb of the two groups were compared, and the differences were statistically significant (P＜0.05). The results of correlation analysis showed that UAlb was positively correlated with the course of disease, SDBG and MDA in patients with type 2 diabetes (r=0.298, 0.435, 0.673, P＜0.05). There was a negative correlation between UAlb and SOD (r=-0.716, P＜0.05). SOD was negatively correlated with SDBG (r=-0.294, P＜0.05). MDA was positively correlated with SDBG (r=0.282, P＜0.05). Conclusion The course of diabetes, the fluctuation of blood glucose and the level of oxidative stress are correlated with the occurrence and development of diabetic nephropathy.

Key words： Type 2 diabetic nephropathy Blood glucose fluctuation Oxidative stress

基金资助:新疆维吾尔自治区乌鲁木齐市科技计划项目（Y151310008）

通讯作者: 卢雪玲，女，硕士，主任医师，硕士研究生导师，任职于新疆医科大学第二附属医院

作者简介: 范玲燕（1989-），女，新疆医科大学2017 级内分泌及代谢病学在读硕士研究生

引用本文:

范玲燕；卢雪玲. 2型糖尿病肾病与血糖波动及氧化应激水平的相关性分析[J]. 中国当代医药, 2020, 27(16): 102-105.
FAN Ling-yan； LU Xue-ling. Correlation analysis of type 2 diabetic nephropathy with blood glucose fluctuation and oxidative stress. 中国当代医药, 2020, 27(16): 102-105.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I16/102

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