Abstract：Objective To study the effect of lung protective ventilation strategy on inflammatory response and oxidative stress after thoracoscopic radical resection of lung cancer.Methods A total of 75 patients with thoracoscopic radical resection of lung cancer admitted to our hospital from July 2017 to July 2018 were selected as the research objects.All patients were divided into observation group (38 cases) and control group (37 cases) according to the random number table method.The control group was treated with conventional ventilation strategy,and the observation group was treated with lung protective ventilation strategy.The inflammatory response indexes (interleukin-10 [IL-10],interleukin-8[IL-8],tumor necrosis factor-α [TNF-α]) and oxidative stress indexes (malondialdehyde [MDA],superoxide dismutase[SOD]) were compared between the two groups before and after operation.The pulmonary function of the two groups was scored with the standard pulmonary function scale.The incidence of pulmonary complications was recorded within 3 days after operation in both groups.Results The levels of IL-10,IL-8 and TNF-α after operation in the two groups were lower than those before operation,and the differences were statistically significant (P＜0.05).The levels of IL-10,IL-8 and TNF-α in the observation group after operation were lower than those in the control group,and the differences were statistically significant (P＜0.05).The levels of MDA in the two groups after operation were lower than those before operation,SOD and pulmonary function score were higher than those before operation,and the differences were statistically significant (P＜0.05).The MDA of the observation group after operation was lower than that of the control group,SOD and pulmonary function score were higher than those of the control group,and the differences were statistically significant (P＜0.05).The total incidence rate of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The lung protective ventilation strategy can significantly reduce the inflammatory response and oxidative stress after thoracoscopic radical resection of lung cancer,and improve the lung function.It has high application value in clinical practice,and it is worth popularizing.
Costa Leme A，Hajjar LA，Volpe MS，et al.Effect of intensive vs moderate alveolar recruitment strategies added to lung-protective ventilation on postoperative pulmonary complications：a randomized clinical trial[J].JAMA，2017，317（14）：1422-1432.
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