Clinical effect of Edaravone combined with mild hypothermia in the treatment of severe craniocerebral injury
ZHONG Xian-liang DU Bo ZHONG Yuan-bo XU Jian-zhong SHAN Ai-jun
Department of Emergency, the Second Clinical Medical College of Ji′nan University, Shenzhen People′s Hospital,Guangdong Province, Shenzhen 518020, China
Abstract：Objective To investigate the clinical value of Edaravone combined with mild hypothermia in the treatment of severe craniocerebral injury.Methods A total of 89 patients with severe craniocerebral injury admitted to the emergency ward and intensive care unit of our hospital from January 2015 to December 2016 were selected as the study subjects.They were divided into the control group(n=44)and the observation group(n=45) according to the random number table method.Patients in the control group were treated with Edaravone, and patients in the observation group were treated with Edaravone combined with mild hypothermia.The neurological deficit (NIHSS) scores, Glasgow coma scale(GCS) scores, middle cerebral artery blood flow velocity (Vm), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6)and oxidative stress indicators [superoxide dismutase 1 (SOD-1), malondialdehyde (MDA)] were compared between the two groups before and after treatment.Results There were no significant difference in NIHSS score, GCS score and Vm between the two groups before treatment (P>0.05).The NIHSS scores of the two groups after treatment were significantly lower than those before treatment, the GCS scores and Vm were significantly higher than those before treatment, and the differences were statistically significant (P<0.05).The NIHSS score in the observation group after treatment was significantly lower than those in the control group, the GCS score and Vm were significantly higher than those in the control group, and the differences were statistically significant (P<0.05).There were no significant difference in the levels of TNF-α and IL-6 between the two groups before treatment (P>0.05).The levels of TNF-α and IL-6 of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P<0.05).The levels of TNF-α and IL-6 in the observation group after treatment were lower than those in the control group, and the differences were statistically significant (P<0.05).There were no significant difference in the levels of SOD-1 and MDA between the two groups before treatment (P>0.05).The levels of SOD-1 in the two groups after treatment were higher than those before treatment, the MDA levels were lower than those before treatment, and the differences were statistically significant (P<0.05).The level of SOD-1 in the observation group after treatment was higher than that in the control group, the MDA level was lower than that in the control group, and the differences were statistically significant (P<0.05).Conclusion The combination of Edaravone and mild hypothermia in the treatment of patients with severe craniocerebral injury has the significant effect and good application prospects.
钟贤良；杜波；钟源波；徐建忠；单爱军. 依达拉奉联合亚低温治疗重型颅脑损伤的临床效果[J]. 中国当代医药, 2019, 26(15): 58-61.
ZHONG Xian-liang； DU Bo； ZHONG Yuan-bo； XU Jian-zhong； SHAN Ai-jun. Clinical effect of Edaravone combined with mild hypothermia in the treatment of severe craniocerebral injury. 中国当代医药, 2019, 26(15): 58-61.
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