Abstract：Objective To explore the clinical effect of Estradiol Valerate in the adjuvant treatment of patients with senile vaginitis. Methods A total of 84 patients with senile vaginitis treated in our hospital from February 2016 to February 2019 were selected as research subjects. They were divided into observation group (n=42) and control group (n=42)according to random number table method. Patients in the control group received Lactobacillus Vagina Capsules orally，and in the observation group they received oral administration of Lactobacillus Vagina Capsules and Estradiol Valerate.The clinical efficacy，inflammatory factor levels of vaginal secretion，relapse rate and adverse reactions of the two groups were compared. Results The total effective rate of treatment in the observation group was 92.86%，higher than that of the control group accounting for 71.43% with statistical significance (P＜0.05). The levels of interleukin-6 (IL-6)，interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in the vaginal secretions before treatment in the two groups were compared without statistical significance (P＞0.05). After seven days of treatment，the levels of IL-6，IL-8 and TNF-α in the two groups were lower than those before treatment. The levels of IL-6，IL-8 and TNF-α in the observation group were lower than those of the control group，and the differences were statistically significant (P＜0.05).The relapse rate in the observation group during six months after treatment was 4.76%，lower than that of the control group accounting for 21.43%，with statistical significance (P＜0.05). No obvious adverse reactions occurred during the treatment of the two groups. Conclusion The use of Estradiol Valerate as an adjuvant therapy to treat patients with senile vaginitis can effectively improve clinical symptoms，reduce levels of inflammatory factors in vaginal secretion and relapse. It is safe，and is worthy of clinical promotion.
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