Abstract：Objective To explore the clinical effect of radical transurethral resection of bladder tumor in the treatment of senile muscular invasive bladder cancer.Methods Ninety patients with senile muscular invasive bladder cancer treated in our hospital from January 22, 2016 to January 22, 2019 were selected as the research subjects, and they were divided into control group (45 cases) and observation group (45 cases) according to the database odd and even random method.Patients in the control group were treated with partial bladder resection, and patients in the observation group were treated with radical transurethral resection of bladder tumor.The total incidence rate of complications, intraoperative blood loss, operation time, hospitalization time, resection margin negative rate, recurrence rates within 3 and 6 months, health-related quality of life (HRQOL) and function assesment of cancer therapy-bladder cancer form (FACTBL) scores before and after treatment were compared between the two groups.Results The total incidence rate of complications in the observation group (2.22%), the recurrence rate within 3 months (0.00%), and the recurrence rate within 6 months (2.22%) were lower than those in the control group (26.67%, 8.89%, 15.56%), and the differences were statistically significant (P＜0.05).The intraoperative blood loss of the observation group ([43.68±5.79]ml) was less than that of the control group ([56.19±7.18]ml), and the difference was statistically significant (P＜0.05).The operation time([23.41±2.33]min) and hospitalization time ([7.89±2.13]d) of the observation group were shorter than those of the control group ([38.96±5.46]min, [9.75±2.54]d), and the differences were statistically significant (P＜0.05).The resection margin negative rate of patients in the observation group (97.78%) was higher than that in the control group (73.33%),and the difference was statistically significant (P＜0.05).The HRQOL score ([56.79±6.22]points) and FACT-BL score([84.63±7.46]points)of the observation group were higher than those of the control group([42.38±4.54],[72.51±5.11]points),and the differences were statistically significant (P＜0.05).Conclusion The effect of radical transurethral resection of bladder tumor is significant in the treatment of senile patients with muscular invasive bladder cancer
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