Abstract：Objective To explore the application of Alteplase combined with Clopidogrel in patients with acute ischemic mild stroke (AIMS). Methods A total of 154 patients with AIMS admitted to our hospital from January 2018 to May 2019 were selected. According to the random number table method，they were divided into observation group and control group，with 77 cases in each group. Patients in the control group received conventional methods of lowering blood glucose and blood pressure besides Alteplase treatment. In the observation group，on the basis of the control group，Clopidogrel was added. Followed up for 3 months，the National Institute of Health stroke scale (NIHSS) score and the modified Rankin scale score，laboratory indicators，Barthel index and activity of daily living (ADL) score，and adverse events were compared in the two groups. Results The NIHSS and modified Rankin scale scores of the observation group after treatment were lower than those of the control group，and the differences were statistically significant(P＜0.05). The Barthel index and ADL score of the observation group after treatment were higher than those of the control group with statistical significances (P＜0.05). There were no significant differences in white blood cell count (WBC)，platelet count (PLT) and platelet count (FIB) between the two groups after treatment (P＞0.05). The total incidence of adverse events in the observation group was 2.60%，lower than 12.99% in the control group，and the difference was statistically significant (P＜0.05). Conclusion Alteplase combined with Clopidogrel is effective in the treatment of patients with AIMS and has a high safety.
明子歆. 阿替普酶联合氯吡格雷在急性缺血性轻型脑卒中患者中的应用[J]. 中国当代医药, 2020, 27(18): 146-148.
MING Zi-xin. Application of Alteplase combined with Clopidogrel in patients with acute ischemic mild stroke. 中国当代医药, 2020, 27(18): 146-148.
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