Abstract：Objective To analyze related influencing factors of relapse in children with acute lymphoblastic leukemia(ALL) children after CCLG-2008.Methods A retrospective analysis was performed on 677 newly diagnosed children who were given CCLG-2008 chemotherapy regimen during the period from January 2010 to January 2015.According to results of follow-up,they were divided into recurrence group (151 cases) and non-recurrence group (526 cases).Univariate and multivariate Logistic regression analysis were performed to analyze risk factors influencing recurrence in ALL children after CCLG-2008 treatment regimen.The main factors influencing recurrence of ALL children were analyzed.Results A total of 677 patients were treated.There were 151 cases with recurrence,with recurrence rate of 22.30%.The proportions of age not less than 10 years old,newly diagnosed white blood cell count more than 100×109/L,bone marrow smear showing M3 on the 15th day,minimal residual lesions greater than 10-4 on the 12th week and high risk level in recurrence group were higher than those in non-recurrence group (P＜0.05).Multivariate Logistic regression analysis showed that age not less than 10 years old,newly diagnosed white blood cell count more than 100×109/L,bone marrow smear showing M3 on the 15th day,minimal residual lesions greater than 10-4 on the 12th week and high risk level were independent risk factors influencing recurrence in ALL children(P＜0.05).Conclusion Age not less than 10 years old,newly diagnosed white blood cell count more than 100×109/L,bone marrow smear showing M3 on the 15th day,minimal residual lesions greater than 10-4 on the 12th week and high risk level are independent risk factors influencing recurrence in ALL children.
谢淑佩；梁昌达；范小菊. 急性淋巴细胞白血病患儿经CCLG～2008方案治疗后复发的相关影响因素分析[J]. 中国当代医药, 2020, 27(5): 115-117.
XIE Shu-pei ；LIANG Chang-da； FAN Xiao-ju. Analysis of related influencing factors of relapse in children with acute lymphoblastic leukemia after CCLG-2008. 中国当代医药, 2020, 27(5): 115-117.
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