Curative effect observation of Climen combined with Escitalopram in the treatment of perimenopausal depression
ZHANG Zhi-hua1 WEN Ya-lan2 LUO Hong-yu3
1.Department of Obstetrics and Gynecology, Ganzhou Third People′s Hospital in Jiangxi Province, Ganzhou 341000,China;
2.Department of Gynecology and Obstetrics, Ganzhou Hospital of Traditional Chinese Medicine in Jiangxi Province, Ganzhou 341000, China;
3.Department of Obstetrics and Gynecology, Ganzhou Maternal and Child Health Hospital in Jiangxi Province, Ganzhou 341000, China
Abstract：Objective To explore the application of Estradiol Valproate Tablets/Escitalopram Tablets and Escitalopram in the treatment of perimenopausal depression. Methods A total of 60 patients with perimenopausal depression in Ganzhou Third People′s Hospital from January 2016 to December 2017 were selected as the subjects of the study.According to the random number table method, the patients were divided into the study group (30 cases) and the control group (30 cases).The study group was treated with Estradiol Valproate Tablets/Escitalopram Tablets + Escitalopram Tablets, while the control group was treated with Escitalopram.The Hamilton depression scale (HAMD), therapeutic effect and adverse reactions were compared between the two groups. Results The HAMD scores of the study group at the 4th, 8th and 12th weeks after treatment were lower than those of the control group, the differences were statistically significant (P＜0.05).The total effective rate of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in the study group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Estradiol Valerate Tablets/Escitalopram Tablets combined with Escitalopram are effective in the treatment of permenopausal depression, which can reduce the depression status of patients, improve the therapeutic effect, and have a lower incidence of adverse reactions.
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