Application effect of Dezocine administered at different time points in patients undergoing laparoscopic surgery
YE Hua1 YANG Xian-ping1 ZHU Zhi-qiao2 WANG Jing-ye1 CHEN Min-ling1 TAN Jie-yin2 LIAO Cui2
1.Departmen of Anesthesiology,Yunfu Maternal and Child Health Hospital/Yunfu Maternal and Child Health and Family Planning Service Center,Guangdong Province,Yunfu 527300,China;
2.Department of Gynaecology,Yunfu Maternal and Child Health Hospital/Yunfu Maternal and Child Health and Family Planning Service Center,Guangdong Province,Yunfu 527300,China
Abstract：Objective To compare the application effect of Dezocine administered at different time points in patients undergoing laparoscopic surgery.Methods All of 105 patients scheduled for gynecologic laparoscopy treated in our hospital from June 2016 to July 2018 were selected,and they were randomly divided into group A(n=52)and group B(n=53).Patients in group A received intravenous injection of Dezocine 60 min before end surgery.Patients in group B received same intervene 20 min before end surgery.At the same time,20 patients were set up as blank control group.The recovery time of anesthesia,restlessness score during recovery and incidence of adverse reactions after recovery were compared in patients among the three groups.Results The restlessness score of group A and group B were lower than those of the blank control group at the time of recovery and 5,10 and 20 minutes after extubation(P＜0.05).At 20 minutes after extubation,the agitation score in group B was lower than that in group A(P＜0.05).The recovery time was the longest in group B,followed by group A and the shortest in blank control group(P＜0.05).The total incidence of adverse reactions was 9.62%,9.43%and 10.00%respectively in group A,group B and blank control group at 24 hours after operation,and there was no significant difference (P＞0.05).Conclusion Intravenous injection of appropriate amount of Dezocine before end operation can effectively prevent restlessness during recovery period of general anesthesia in gynecological laparoscopic patients,and intravenous injection of Dezocine 60 minutes before operation can effectively prevent restlessness during recovery period in patients with gynecological laparoscopic surgery.
Boku A，Hanamoto H，Oyamaguchi A，et al.Effectiveness of dexmedetomidine for emergence agitation in infants undergoing palatoplasty：a randomized controlled trial[J].Braz J Anesth，2016， 66（1）：37-43.
[2]
Ying X，Ye W，Na S，et al.Analgesic and sedative effects of dezocine and midazolam during vitrectomy[J].Cur Eye Res，2016，41（11）：1.
Kanaya A.Emergence agitation in children：risk factors，prevention，and treatment[J].J Anesth，2016，30（2）：261-267.
[6]
Prabhu MK，Mehandale SG.Comparison of oral dexmedetomidine versus oral midazolam as premedication to prevent emergence agitation after sevoflurane anaesthesia in paediatric patients[J].Indian J Anaesth，2017，61（2）：131-136.
[7]
Frederick H J，Wofford K，De LDG，et al.A randomized controlled trial to determine the effect of depth of anesthesia on emergence agitation in children[J].Anesth Analg，2016，122（4）：45-47.
[8]
Fang BX，Wang LH，Liu HM，et al.Stability study of dezocine in 0.9%sodium chloride solutions for patient-controlled analgesia administration[J].Medicine，2017，96（35）：e7979.
[9]
Wang L，Liu X，Wang J，et al.Comparison of efficacy and safety between dezocine and Morphine for persistence of pain in cancer patients in Chinese：a meta-analysis[J].Biosc Rep，2017，37（3）：59-61.
Li X，Xia Q，Li W.Comparison of the effects of dezocine，fentanyl，and placebo on emergence agitation after sevoflurane anesthesia in children[J].Int J Clin Pharmacol Ther，2015，53（3）：241-246.
Lu ZT，Yang GH，He QT，et al.Effects of dezocine on emergence agitation and hemodynamics during recovery from sevoflurane-based anesthesia in children[J].Chinese J New Drugs Clin Remed，2014，33（4）：260-262.
[13]
Zhu Z，Jiang W，Cui YF，et al.Preventive effects of dezocine on emergence agitation in children[J].J Clin Anesth，2014，30（1）：24-26.
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