Abstract：Objective To investigate the application effect of preemptive analgesia with Flurbiprofen Axetil and postoperative analgesia with Pentazocine for laparoscopic radical nephrectomy.Methods A total of 40 patients with laparoscopic radical nephrectomy from January 2014 to December 2017 were selected and randomly divided into the observation group and the control group,20 patients in each group.Patients in the observation group were given Flurbiprofen Axetil with 50 mg half an hour before the start and the end of the surgery,while patients in the control group were given the same volume of physiological saline.All patients were treated with intravenous controlled analgesia pump 10 minutes before the end of the operation.Patients in the observation group were treated with Sufentanil with 150 μg+Pentazocine with 60 mg+Tropisetron with 5 mg,while patients in the control group were treated with Sufentanil with 200 μg+Tropisetron with 5 mg.The mean arterial pressure(MAP)and heart rate(HR)were observed before anesthetization(T0)and at the time of operation starting(T1),operation ending(T2)and extubation(T3)in the two groups.The levels of interleukin-6 (IL-6)and tumor necrosis factor-α (TNF-α)were detected before anesthetization and at the time of 2,12,24 h after operation in the two groups.The VAS scores and BCS scores were recorded at the time of 2,12,24 h after operation in the two groups.The press times of PCIA and the incidence rate of adverse reactions were observed in the two groups.Results At T1,T2and T3,the values of MAP and HR in the observation group were significantly lower than those in the control group(P＜0.05).At the 12 h and 24 h after operation,the level of IL-6 and TNF-α in the observation group were significantly lower than those in the control group(P＜0.05).The VAS scores in the observation group were significantly higher than those in the control group(P＜0.05)at the same time point,while the BCS scores in the observation group were significantly lower than those in the control group(P＜0.05)at the same time point.The press times of PCIA in the observation group were significantly lower than those in the control group(P＜0.05),and the incidence of postoperative nausea in the observation group was significantly lower than those in the control group,with significant difference (P＜0.05).Conclusion The analgesic effect of preemptive analgesia with Flurbiprofen Axetil and postoperative analgesia with Pentazocine for laparoscopic radical nephrectomy is definite,which can effectively reduce the stress response and adverse reactions.
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