Abstract：Objective To investigate the value of serum cholylglycine（CG）in intrahepatic cholestasis of pregnancy（ICP）. Methods 80 cases of ICP patients from January 2014 to October 2015 in our hospital were choosed，they were divided into 46 mild cases（mild ICP group）and 34 serious cases（serious ICP group），the control group was 60 health pregnancy women for the same period.All of cases were detected the CG level by radioimmunoassay.The results were monitored and analyzed.Results The CG levels in the ICP groups was significantly higher than that of the control group respectively（P＜0.05）.The CG level in the serious ICP group was significantly higher than that in the mild ICP group（P＜0.05）. The rates of meconium-stained，amniotic，fluid，fetal-distress，premature，neonatal asphyxia and stillbirth were increased significantly with increase of CG levels.The rates of meconium-stained，amniotic，fluid，fetal-distress，premature，neonatal asphyxia and stillbirth in the group C and group B was higher than that of group A respectively.The rates of meconiumstained，amniotic，fluid，fetal-distress，premature，neonatal asphyxia and stillbirth in the group C was higher than that of group B respectively（P＜0.05）.Conclusion CG is an important monitoring index of ICP patients in perinatal period.
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