Abstract：ObjectiveTo explore the changes of serum thyroid function and immune content in patients with hyperthyroidism during pregnancy and its clinical application.Methods122 pregnant patients with hyperthyroidism treated from May 2015 to December 2016 in our hospital were selected as the observation group,120 pregnant women without hyperthyroidism were selected as the control group at the same time.The immune function and thyroid function at the different gestational periods between the two groups were compared.ResultsThe index of TSH at the early,mid,late trimester of pregnancy in the observation group was lower than that in the control group,the level of T3,FT3,T4,FT4at the early,mid,late trimester of pregnancy in the observation group was higher than that in the control group,with significant difference (P＜0.05).The positive rate of TRAb,Anti-TG and TPOAb at the early,mid trimester of pregnancy in the observation group was higher than that in the control group,with significant difference (P＜0.05).There was no significant difference in the positive rate of TRAb between the two groups (P＞0.05).The positive rate of Anti-TG and TPOAb at the late trimester of pregnancy in the observation group was higher than that in the control group,with significant difference (P＜0.05).ConclusionThe thyroid function and immunoglobulin contents at the different gestational periods are significantly different.It is necessary to attach great importance to this kind of patient,to diagnose and treat early,to check the thyroid function regularly and improve the outcome of maternal and infant.
梁妙芝 ;陈冬莲; 王飞马 ;宋兴贤 ;杨莹. 妊娠期甲状腺功能亢进症患者血清甲状腺功能和免疫含量变化及其临床应用[J]. 中国当代医药, 2018, 25(3): 154-156.
LIANG Miao-zhi;CHEN Dong-lian; WANG Fei-ma;SONG Xing-xian; YANG Ying. Changes of serum thyroid function and immune content and its clinical application in patients with hyperthyroidism during pregnancy. 中国当代医药, 2018, 25(3): 154-156.
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