妊娠期甲状腺过氧化物酶抗体与甲状腺功能及不良妊娠结局的关系

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摘要目的探讨妊娠期甲状腺过氧化物酶抗体（TPOAb）与甲状腺功能及不良妊娠结局的关系。方法选择2016年2月～2017年4月我院收治的甲状腺激素水平正常的孕妇242例，根据TPOAb检测结果分为观察组（n=120，TPOAb阳性组）与对照组（n=122，TPOAb阴性组），追踪随访观察两组妊娠女性妊娠中晚期甲状腺功能及不良妊娠结局情况。结果观察组患者妊娠中晚期甲状腺功能异常发生率为20.8%，显著高于对照组的7.3%，差异有统计学意义（P＜0.05）；观察组患者妊娠不良结局发生率为30.0%，显著高于对照组的12.3%，差异有统计学意义（P＜0.05）。结论TPOAb阳性孕妇妊娠期间发生甲状腺激素水平异常及不良妊娠结局的机率较高，妊娠期间要加强对甲状腺功能的监测，提高妊娠安全。

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	陈红

关键词 ：甲状腺过氧化物酶抗体, 甲状腺功能, 妊娠结局

Abstract：ObjectiveTo discuss the relationship between thyroid peroxidase antibody(TPOAb)and thyroid function and adverse pregnancy outcomes in pregnancy.Methods242 pregnant women who visit at department of obstetrics and gynecology in our hospital from Feb 2016 to Apr 2017 and level of thyroid hormone was normal were divided into the observation group(n=120,TPOAb positive)and the control group(n=122,TPOAb negative)according to the results of TPOAb results.Then the thyroid function and adverse pregnancy outcomes were contrasted between the two groups.ResultsThe incidence of thyroid dysfunction was 20.8%in the observation group,which was significantly higher than 7.3%in the control group(P＜0.05).The incidence of adverse pregnancy outcome was 30.0%,which was significantly higher than 12.3%in the control group (P＜0.05).ConclusionThe incidence of thyroid hormone abnormal and adverse pregnancy outcome in middle and late pregnancy is high in TPOAb positive pregnant woman,and thyroid function tests should be strengthened in pregnancy,and improve pregnancy safety.

Key words： Thyroid peroxidase antibody Thyroid function Pregnancy outcome

引用本文:

陈红. 妊娠期甲状腺过氧化物酶抗体与甲状腺功能及不良妊娠结局的关系[J]. 中国当代医药, 2017, 24(35): 65-67.
CHEN Hong. Relationship between thyroid peroxidase antibody and thyroid function and adverse pregnancy outcomes in pregnancy. 中国当代医药, 2017, 24(35): 65-67.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2017/V24/I35/65

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