Abstract：Objective To investigate risk factors and prevention measures in newborns with multidrug-resistant organisms（MDROs）infection.Methods A retrospective analysis wasmade on clinical data of 63 newborns with MDROs in NICU from January 2015 to January 2016，and 63 non-MDROs newbornswere choose as control group，risk factorswere analyzed by one-way ANOVA and logistic regress statistic.Resu lts one-way ANOVA analysis shew that gestational age，average hospitalization time（＞1 week），antibiotic therapy，tracheal intubation，PICC，gastric tube insertion，total parenteral nutrition were risk factors of MDROs，then Logistic regress shew that antibiotic therapy and average hospitalization time were independent risk factors.Conclusion Frequent antibiotic therapy and long-term hospitalization can cause MDROs infection，in which mechanisms include the SOS pathway and acquisition of resistance genes by HGT.Therefore，shortening the long-term hospitalization and reducing frequency of antibiotic therapy are the main measures to prevent the MDROs infection.
李松;罗玲. 新生儿多重耐药菌感染的危险因素分析[J]. 中国当代医药, 2016, 23(21): 72-74转77.
LI Song ;LUO Ling. Risk factors analysis of multidrug-resistant organism s infection in newborns. 中国当代医药, 2016, 23(21): 72-74转77.
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