Analysis on the incidence and drug resistance of extended spectrum βlactamases in Klebsiella and Escherichia coli from patients with hospital acquired pneumonia
GONG Wei CHEN Ying-hua ZHAO Jian-min
Department of Laboratory,the First People′s Hospital of Ji′an City,Jiangxi Province,Ji′an 343000,China
Abstract:Objective To analyze the incidence and drug resistance of extended spectrum β-lactamases in Klebsiella and Escherichia coli from patients with hospital acquired pneumonia.Methods A total of 104 patients with hospital acquired pneumonia admitted to the First People′s Hospital of Ji′an City from March 2018 to January 2020 were selected for retrospective analysis.The DL-96Ⅱwas mainly used for drug sensitivity test and strain identification,extended spectrum β-lactamases were detected by Kirby-Bauer method,and their incidence and drug resistance characteristics were analyzed.Results There was no significant difference in the positive rate of extended spectrum β-lactamases between Klebsiella and Escherichia coli(P>0.05).Extended spectrum β-lactamases in Escherichia coli showed drug resistance to Ampicillin,Paediatric Compound Sulfamethoxazole Tablets,Aztreonam,Cefperazone/Sulbactam,Piperacillin/Tazobactam,Ceftazidime,Levofloxacin,Imipenem,Cefoxitin and Amikacin,and promoted over time.Conclusion The incidence of extended spectrum β-lactamases in Klebsiella and Escherichia coli from patients with hospital acquired pneumonia is high,and drug resistance also shows gradually increasing trend in recent years.
龚伟;陈樱花;赵剑敏. 医院获得性肺炎患者克雷伯菌、大肠埃希菌中超广谱β-内酰胺酶菌株的发生率和耐药特点分析[J]. 中国当代医药, 2021, 28(17): 190-192.
GONG Wei; CHEN Ying-hua; ZHAO Jian-min. Analysis on the incidence and drug resistance of extended spectrum βlactamases in Klebsiella and Escherichia coli from patients with hospital acquired pneumonia. 中国当代医药, 2021, 28(17): 190-192.
Zhang H,Yang Q,Liao K.Update of incidence and antimicrobial susceptibility trends ofEscherichia coliandKlebsiellapneumoniae isolates from Chinese intra-abdominal infection patients[J].BMC Infect Dis,2017,17(1):776-776.
Shankar C,Veeraraghavan B,Nabarro LEB,et al.Whole genome analysis of hypervirulentKlebsiellapneumoniae isolates from community and hospital acquired bloodstream infection[J].BMC Microbiol,2018,18(1):6.
Johnson JK,Robinson GL,Pineles LL,et al.Carbapenem MICs inEscherichia coliandKlebsiellaSpecies Producing Extended-Spectrum β-Lactamases in Critical Care Patients from 2001 to 2009[J].Antimicrob Agents Chemother,2017,61(4):e01718-16.