Abstract:Objective To explore the application effect of vaginal preparation Conjugated Estrogen Cream combined with comprehensive nursing intervention on severe uterine prolapse before vaginal preparation.Methods A total of 98 cases of severe uterine prolapse treated in our hospital from January 2017 to December 2018 were selected and divided into control group and research group according to random number table method,49 cases in each group.The two groups were given Conjugated Estrogen Cream vaginal medicine,in which the control group received routine nursing intervention,while the research group received comprehensive nursing intervention.Psychological status,total nursing satisfaction and complications were compared between the two groups.Results The hospital anxiety and depression scale(HADS)score of the research group was(6.87±2.15)points,lower than that of the control group for(10.48±2.57)points,the difference was statistically significant(P<0.05).The total nursing satisfaction of the research group was 95.92%,higher than that of the control group for 81.63%,(P<0.05).The total incidence of complications in the research group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion The combination of Conjugated Estrogen Cream and comprehensive nursing can effectively improve the preoperative psychological state of patients with severe uterine prolapsed,improve nursing satisfaction,reduce postoperative complications and facilitate the recovery of patients.