补肾通络法联合阿仑磷酸钠治疗强直性脊柱炎合并骨质疏松的临床效果

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摘要目的探讨补肾通络法联合阿仑磷酸钠治疗强直性脊柱炎（AS）合并骨质疏松（OP）的临床效果。方法选取2017年8月～2018年6月我院收治的80 例AS 合并OP 患者，按照随机数字表法分为对照组（40 例）和干预组（40 例），对照组采用阿仑磷酸钠治疗，干预组加用补肾通络法治疗，比较两组患者治疗前后的腰椎（L2～4）、股骨颈、大转子的骨密度（BMD），骨钙素（BGP）、Ⅰ型前胶原氨基端延长肽（PⅠNP）、Ⅰ型胶原交联羧基末端肽（CTX）含量，并观察治疗后的临床总有效率。结果治疗后，两组患者的L2～4、股骨颈和大转子的BMD 高于治疗前，两组患者的BGP、PⅠNP 水平高于治疗前，CTX 水平低于治疗前，干预组的L2～4、股骨颈和大转子的BMD 高于对照组，干预组的BGP、PⅠNP 水平高于对照组，CTX 水平低于对照组，差异均有统计学意义（P＜0.05）。干预组的临床总有效率为92.50%，高于对照组的75.00%，差异有统计学意义（P＜0.05）。结论AS 合并OP 患者采用补肾通络法联合阿仑磷酸钠治疗可显著提高临床疗效，改善骨代谢和BMD 指标。

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关键词 ：强直性脊柱炎, 骨质疏松, 补肾通络法, 阿仑磷酸钠, 骨代谢, 骨密度

Abstract：Objective To explore the clinical effect of Bushen Tongluo method combined with Alendronate Sodium in the treatment of ankylosing spondylitis with osteoporosis.Methods Eighty patients with ankylosing spondylitis (AS) and osteoporosis (OP) admitted to our hospital from August 2017 to June 2018 were selected and divided into the control group (40 cases) and the intervention group (40 cases) according to the random number table method.The control group was treated with Alendronate Sodium.The intervention group was treated combined with Bushen Tongluo method.The bone mineral density (BMD) of the lumbar vertebrae (L2-4),femoral neck and greater trochanter before and after treatment,bone-carboxyglutamate protein (BGP),procollagen type Ⅰamino-terminal prolonging peptide (PⅠNP),carboxyterminal telopeptide of type Ⅰcollagen (CTX) content were compared between the two groups,and the total clinical effectiveness after treatment was observed.Results After treatment,the BMD of L2-4,femoral neck and greater trochanter were higher than those before treatment.The BGP and PⅠNP levels of the two groups were higher than those before treatment,and the CTX level was lower than that before treatment.The BMD of L2-4,femoral neck and greater trochanter of the intervention group were higher than those of the control group.The BGP and PⅠNP levels in the intervention group were higher than those in the control group,and the CTX level was lower than that in the control group,the differences were statistically significant (P＜0.05).The total effective rate of the intervention group was 92.50%,which was higher than that of the control group (75.00%),and the difference was statistically significant (P＜0.05).Conclusion The combination of Bushen Tongluo method and Alendronate Sodiumin in the treatment of patients with AS and OP can significantly improve clinical efficacy and improve bone metabolism and BMD.

Key words： Ankylosing spondylitis Osteoporosis Bushen Tongluo method Alendronate Sodium Bone metabolism;Bone mineral density

引用本文:

陈念. 补肾通络法联合阿仑磷酸钠治疗强直性脊柱炎合并骨质疏松的临床效果[J]. 中国当代医药, 2020, 27(1): 115-117转120.
CHEN Nian. Clinical effect of Bushen Tongluo method combined with Alendronate Sodium in the treatment of ankylosing spondylitis with osteoporosis. 中国当代医药, 2020, 27(1): 115-117转120.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I1/115

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