Abstract：Objective To investigate the effect of acupuncture combined with conventional drugs on ankylosing spondylitis.Methods A total of 80 patients with ankylosing spondylitis admitted to our hospital from January 2016 to January 2018 were selected as the study subjects,and they were randomly divided into 40 cases of the control group and 40 cases of the observation group according to different treatment methods.The patients in the control group were treated with oral Diclofenac Sodium and Sulfasalazine,and the observation group was given acupuncture treatment on the basis of the control group.All the patients had been treated for 2 courses,30 d for a course.Before and after treatment,two groups of patients were evaluated for TCM symptoms,the thoracic activity and spinal activity were measured,the bath ankylosing spondylitis disease activity index(BASDAI)and bath ankylosing spondylitis function index(BASFI)were evaluated.Quality of life improvement was assessed by SF-36 quality of life scale,C-reactive protein(CRP)was detected by ELISA,and tumor necrosis factor(TNF-α)was detected by radioimmunoassay.Adverse reactions in both groups were recorded.Results The scores of TCM symptoms such as lumbosacral pain,low back pain and morning stiffness after treatment in the control group and the observation group were significantly lower than those before treatment,the differences were statistically significant(P＜0.05),the thoracic activity and spinal activity were significantly higher than before treatment,the differences were statistically significant(P＜0.05).The scores of TCM symptoms such as lumbosacral pain,low back pain and morning stiffness in the observation group after treatment were significantly lower than the control group,the differences were statistically significant(P＜0.05),the thoracic activity and spinal activity were significantly higher than the control group,the differences were statistically significant(P＜0.05).The BASDAI index,BASFI index,CRP and TNF-α after treatment in the control group and the observation group were significantly lower than those before treatment,the differences were statistically significant(P＜0.05).After treatment,the BASDAI index,BASFI index,CRP,TNF-α in the observation group were significantly lower than the control group,the differences were statistically significant(P＜0.05).The scores of the SF-36 quality life scales in the control group and the observation group after treatment were significantly lower than those before treatment,the differences were statistically significant(P＜0.05).The scores of the SF-36 quality of life scales in the observation group after treatment were significantly lower than the control group,the differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion Acupuncture can effectively relieve pain,improve thoracic activity,spinal activity,reduce inflammation,improve disease and quality of life,and has good safety in the treatment of ankylosing spondylitis.
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