Influence of oral administration of 1200 IU Vitamin D3 on serum vitamin D,bone mineral density and lower extremity function in elderly patients with vitamin D-deficient
CHEN Ping-jun1 HUANG Xiao-hong1 WANG Xia1 XIAO Ting1 LIU Qi-sheng2
1.Department of Geriatrics,the First People′s Hospital of Jiujiang Ciry,Jiangxi Province,Jiujiang 332000,China;
2.Department of General Surgery,the First People′s Hospital of Jiujiang Ciry,Jiangxi Province,Jiujiang 332000,China
Abstract：ObjectiveTo investigate the influence of oral administration of 1200 IU Vitamin D3on serum 25-hydroxyvitamin D[25(OH)D],bone mineral density(BMD)and lower extremity function in elderly patients with vitamin D-deficient.Methods From October 2015 to December 2016,56 elderly patients with vitamin D-deficient treated in our hospital were selected as research subjects.According to vitamin D3took or not,they were divided into the control group(n=29)and observation group(n=27).In the control group,30 min sun bathe daily and proper exercise were necessary.In the observation group,on the basis of the control group,oral administration of Vitamin D3and Caltrate D was added.25(OH)D,osteocalcin,parathyroid hormone,BMD,and walking time of lower extremities were compared between the two groups before intervention,and after 6 and 12 months intervention.Results The serum calcium,serum 25(OH)D,osteocalcin and BMD of the two groups were higher than those before intervention,and after 6 and 12 months intervention,and the above-mentioned indexes in the observation group were all higher than those in the control group (P＜0.05).PTH level after 6 and 12 months intervention in the two groups was lower than that before intervention,and PTH level of in the observation group after 6 and 12 months intervention was lower than in the control group (P＜0.05).The muscle strength of the two groups after intervention was better than that before intervention (P＜0.05).The 8 step walking time after 6 and 12 months intervention in the observation group was longer than that in the control group (P＜0.05).Conclusion O-ral administration of 1200 IU vitamin D3 is beneficial to bone health,and improve BMD as well as the lower limbs function,which has a certain clinical application value and is worthy of promotion and application.
陈平君；黄小红；王霞； 肖婷；刘奇盛. 口服1200 IU 维生素D3对维生素D 缺乏老年人血清维生素D、骨密度及下肢功能的影响[J]. 中国当代医药, 2018, 25(7): 28-30.
CHEN Ping-jun；HUANG Xiao-hong；WANG Xia；XIAO Ting；LIU Qi-sheng. Influence of oral administration of 1200 IU Vitamin D3 on serum vitamin D,bone mineral density and lower extremity function in elderly patients with vitamin D-deficient. 中国当代医药, 2018, 25(7): 28-30.
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