Effect of Bisoprolol combined with Enalapril and Spironolactone in the treatment of rheumatic heart disease patients with chronic heart failure
XIE Guo-bo1 ZHONG Yan-jia2 SHENG Guo-tai1 YU Mao-Sheng1 YANG Ming1
1.The First Department of Cardiology,Jiangxi Provincial People′s Hospital,Nanchang 330006,China;
2.Department of Endocrinology,Jiangxi Provincial People′s Hospital,Nanchang 330006,China
Abstract：ObjectiveTo observe and compare the efficacy of Bisoprolol and Enalapril combined with Spironolactone in the treatment of rheumatic heart disease patients with chronic heart failure.MethodsFrom June 2015 to June 2016,94 patients with rheumatic heart disease and chronic heart failure were selected as study objects and randomly divided into experimental group and control group,47 cases in each group.The patients in the control group were given routine drug treatment,while patients in the experimental group were treated with Bisoprolol and Enalapril combined with Spironolactone.The therapeutic effect of two groups were observed and compared.ResultsAfter treatment,the total effective rate in the experimental group was 95.75%(45/47),which was significantly higher than 82.98%(39/47)in the control group,and the difference was statistically significant(P＜0.05).The LVESD,LVEDD and LVEF of the experimental group was significantly better than that of the control group,and the difference was statistically significant(P＜0.05).ConclusionThe combination of Bisoprolol,Enalapril and Spironolactone is effective in the treatment of rheumatic heart disease with chronic heart failure.It is worthy to be further studied and applied.
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