Objective To investigate and analyze the pharmaceutical care in primary medical institutions of South of Shandong Province，and to discuss the development countermeasures of pharmaceutical care.Methods Questionnaire survey of present situation of pharmaceutical care was conducted among pharmacist from 63 primary medical institutions of South of Shandong，and the results of the survey from January 2015 to January 2016 were analyzed statistically. Results Results of the survey showed that pharmacy personnel degree levelwas uneven and highly educated pharmacy personnel was serious lack.Results of the survey showed that pharmaceutical care in primary medical institutions still focused on"prescription audit and apply for drug purchase".The lack of clinical knowledge was the biggest obstacle for pharmacy staff in primary medical institutions.Itwas suggested to strengthen continuing the training ofmedical knowledge for pharmacists，etc..Conclusion Under the new medical reform，medical staff of grassrootsmedical institutions in South of Shandong Area should constantly improve their own professional level，change the service concept，carry out pharmaceutical services of combined the characteristics，and ensure drug use safety.nd characteristics of the unit to carry out pharmaceutical care，guarantee drug safety.