Abstract：Objective To investigate the predictive value of sentinel lymph node biopsy （SLNB）for axillary lymph node staging after neoadjuvant chemotherapy （NAC）.Methods Thirty-one new breast cancer patients admitted to our hospital from January 2017 to March 2018 were selected as the research objects,and were divided into control group（16 cases）and experimental group（15 cases） by random number table method.After NAC,SLNB was performed in the experimental group,followed by modified radical mastectomy plus axillary lymph node dissection.The control group underwent NAC after SLNB,followed by modified radical mastectomy plus axillary lymph node dissection.The detection rate,false negative rate,accuracy,negative sensitivity and sentinel lymph node metastasis rate of the two groups were compared through the pathological conditions of the detected lymph nodes.Results There was no statistically significant difference in false negative rate,accuracy and negative sensitivity between the two types of patients(P>0.05).The detection rate of sentinel lymph node metastasis in the experimental group was lower than that in the control group,and the difference was statistically significant (P ＜0.05）.Conclusion Sentinel lymph node biopsy after neoadjuvant chemotherapy can also predict axillary lymph node metastasis,but further study is needed for long-term prognosis.
Boughey JC，Suman VJ，Mittendorf EA，et al.Factors affecting sentinel lymph node identification rate after neoadjuvant chemotherapy for breast cancer patients enrolled in ACOSOG Z1071（Alliance）[J].Ann Surg，2015，261（3）：547-552.
[6]
FernandezLJ，BearHD.AxillaryNodeManagementinPatients Receiving Neoadjuvant Chemotherapy[J].Current Breast Cancer Reports，2015，7（1）：30-36.
[7]
Caudle AS，Yang WT，Mittendorf EA，et al.Selective surgical localization of axillary lymph nodes containing metastases in patients with breast cancer：a prospective feasibility trial[J].JAMA Surg，2015，150（2）：137-143.
[8]
Matsumoto A，Jinno H，Nakamura T，et al.Technical feasibility of sentinel lymph node biopsy in patients with ipsilateral breast tumor recurrence and previous axillary surgery[J].Int J Surg，2015，（22）：28-31.
[9]
Tirelli G，Cova MA，Boscolo-Rizzo P，et al.Charcoal Suspension Tattoo A New Technique for Intraoperative Detection of Small Tumors of the Parotid Gland[J].Ann Otol Rhinol Laryngol，2016，125（7）：529-535.
[10]
Tirelli G，Cova MA，Zanconati F，et al.Charcoal suspension tattoo：new tool for the localization of malignant laterocervical lymph nodes[J].Eur Arch Otorhinolaryngol，2016，273（11）：3973-3978.
[11]
Feng J，Pardoe CI，Mota AM，et al.Two-Stage Latissimus Dorsi Flap with Implant for Unilateral Breast Reconstruction：Getting the Size Right[J].Arch Plast Surg，2016，43（2）：197-203.
[12]
Xing Y，Foy M，Cox DD，et al.Meta-analysis of sentinel lymph node biopsy after preoperative chemotherapy in patients with breast cancer[J].Br J Surg，2006，93（8）：1025.
[13]
Tan VK，Goh BK，Fook-Chong S，et al.The feasibility and accuracy of sentinel lymph node biopsy in clinically nodenegative patients afterneoadjuvantchemotherapy for breast cancer-a systematic review and meta-analysis[J].J Surg Oncol，2011，104（1）：97-103.
[14]
van Deurzen CH，Vriens BE，Tjanheijnen VC，et al.Accuracy of sentinel node biopsy after neoadjuvant chemotherapy in breast cancer patients：a systematic review[J].EurJ Cancer，2009，45（18）：3124-3130.
[15]
Fontein DB，van de Water W，van Hezewijk M.Response to：timing of the sentinel lymph node biopsy in breast cancer patients receivingneoadjuvant therapy-recommendations for clinical guidance[J].Eur J Surg Oncol，2013，39（11）：1299.
京公网安备 11010502046607号