ObjectiveTo discuss the effect of cytoreductive surgery and neoadjuvant chemotherapy on advanced ovarian cancer.MethodsFrom January 2011 to January 2014,100 cases with advanced ovarian cancer treated in our hospital and included the study,the patients were randomly divided into two groups by taking the computer single blind grouping method,each group had 50 cases,patients in the control group received cytoreductive surgery,while patients in the observation group received neoadjuvant chemotherapy firstly,then received cytoreductive surgery.The clinical curative effect,operation time,intraoperative blood loss,hospitalization time and the incidence rate of complications were compared between the two groups,and patients were followed up for 3 years,the recurrence rate of 3 years,the survival rate 1 year and 3 years were compared between the two groups.ResultsThe total effective rate in the observation group was significantly higher than the control group,the operation time and hospitalization time were shorter than those of the control group,intraoperative blood loss was fewer than that of the control group,and the incidence rate of complications was significantly lower than those of the control group,the difference was statistically significant(P＜0.05).The recurrence rate of 3 year in the observation group was significantly lower than that of the control group,and the survival rate 1 year and 3 years were significantly higher than those of the control group,the difference was statistically significant(P＜0.05).ConclusionThe combination of cytoreductive surgery and neoadjuvant chemotherapy has a significant therapeutic effect on patients with advanced ovarian cancer and its short-term efficacy and long-term prognosis are relatively good.