Objective To explore the effect of Misoprostol combined with Ergonovine Maleate on coagulation function and stress response in patients with postpartum hemorrhage.Methods The clinical data of 80 postpartum hemorrhage patients admitted to the Third People′s Hospital of Benxi City from May 2018 to February 2020 were analyzed retrospectively.According to different treatment method, they were divided into control group (40 cases) and observation group (40 cases).The control group was treated with Misoprostol, while the observation group was treated with Misoprostol combined with Ergonovine Maleate.The coagulation function, stress response, bleeding after medication and the total incidence of adverse reactions were compared between the two groups before and after treatment.Results After treatment, D- dimer (D-D), prothrombin time (PT) and activated partial thromboplastin time (APTT) in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).After treatment,the levels of norepinephrine (NE) and malondialdehyde (MDA) in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The bleeding volume of the two groups at 24 h after medication was less than that at 2 h after medication, the difference was statistically significant (P＜0.05).The amount of bleeding in the observation group was less than that in the control group at 2 and 24 h after medication, the difference was statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Misoprostol combined with Ergonovine Maleate in the treatment of patients with postpartum hemorrhage can effectively improve their coagulation function and stress response, reduce postpartum hemorrhage, and without increasing the occurrence of adverse reactions at the same time, and has high clinical application value.