Abstract：Objective To compare the effect of Clopidogrel and Aspirin in the treatment of coronary heart disease.Methods A retrospective analysis was conducted on 100 patients with coronary heart disease treated in Yangjiang Traditional Chinese Medicine Hospital from January 2018 to January 2020.According to the treatment drugs,they were divided into two groups: Clopidogrel group (n=50) and Aspirin group (n=50).The clinical efficacy,coagulation functions and adverse reactions of the two groups were statistically analyzed.Results The total effective rate of the Clopidogrel group was 94.0% (47/50),which was higher than the Aspirin group of 62.0% (31/50),the difference was statistically significant (P＜0.05).Comparison of coagulation function indexes before treatment between the two groups showed no statistically significant difference (P＞0.05).After treatment,the platelet aggregation rates of the two groups were lower than those before treatment,and the activated partial thrombin time (APTT) and prothrombin time (PT) were shorter than those before treatment,with statistically significant differences (P＜0.05).The platelet aggregation rate of Clopidogrel group after treatment was lower than that of Aspirin group,and APTT and PT were shorter than those of Aspirin group,with statistically significant differences (P＜0.05).The total incidence of adverse reactions in the Clopidogrel group was 8.0% (4/50),which was lower than 36.0% (18/50) in the Aspirin group,with statistically significant difference (P＜0.05).Conclusion The clinical effect of Clopidogrel in patients with coronary heart disease is better than Aspirin,with fewer adverse reactions,which is worthy of clinical application.
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