Effect of high-flux dialysis combined with hemoperfusion on inflammatory factors and quality of life in elderly chronic renal failure maintenance hemodialysis patients
GUAN Xing-ye
Department of Nephrology, Liaoyang Infectious Diseases Hospital
Abstract：Objective To explore the effect of high-flux dialysis combined with hemoperfusion on inflammatory factors and quality of life in elderly chronic renal failure maintenance hemodialysis patients. Methods A total of 152 patients with chronic renal failure who were admitted to Liaoyang Infectious Diseases Hospital of Liaoning Province from May 2017 to November 2019 were selected as the research objects and divided into the control group and the observation group according to the random number table method, with 76 cases in each group. The control group was treated with high-flux dialysis, and the observation group was treated with high-flux dialysis combined with hemoperfusion. Both groups were treated continuously for 2 months. The levels of blood calcium, blood phosphorus, intact parathyroid hormone (iPTH), inflammatory factors and quality of life were compared between the two groups. Results There were no statistically significant differences in levels of blood calcium, blood phosphorus and iPTH of the two groups before treatment (P>0.05). After 2 months of treatment, the blood calcium and iPTH levels of the two groups were lower than those before treatment, the blood phosphorus levels were higher than those before treatment, and differences were statistically significant (P<0.05). After 2 months of treatment, the blood calcium and iPTH levels of the observation group was lower than that of the control group, the blood phosphorus levels were higher than those of the control group, and differences were statistically significant (P<0.05). There were no statistically significant differences in interleukin-6(IL-6) and tumor necrosis factor-α (TNF-α) between the two groups before treatment (P>0.05). After 2 months of treatment, the levels of IL-6 and TNF-α in the two groups were lower than those before treatment, and differences were statistically significant (P<0.05). After 2 months of treatment, the levels of IL-6 and TNF-α in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). There was no statistically significant difference in general quality of life inventory (GQOLI-74) score between the two groups before treatment (P>0.05). After 2 months of treatment, the GQOLI-74 scores of the two groups were higher than those before treatment, and the differences were statistically significant (P<0.05). After 2 months of treatment, the GQOLI-74 score of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). Conclusion High-flux dialysis combined with hemoperfusion for senile chronic renal failure patients with maintenance hemodialysis can improve calcium-phosphorus metabolism disorder and iPTH secretion disorder, decrease inflammatory state and increase quality of life, which has better clinical efficacy.
关兴晔. 高通量透析结合血液灌流对老年慢性肾衰竭维持性血液透析患者炎症因子与生活质量的影响[J]. 中国当代医药, 2021, 28(3): 115-118.
GUAN Xing-ye. Effect of high-flux dialysis combined with hemoperfusion on inflammatory factors and quality of life in elderly chronic renal failure maintenance hemodialysis patients. 中国当代医药, 2021, 28(3): 115-118.
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