糖皮质激素辅助治疗儿童肺炎支原体大叶性肺炎的临床效果

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摘要目的探讨糖皮质激素（GC）辅助治疗儿童肺炎支原体大叶性肺炎的效果。方法选取2018年7～10月我院收治的肺炎支原体大叶性肺炎40例患儿作为研究对象，按随机摸球法分为对照组和观察组。每组各20例。对照组行常规治疗，观察组在常规基础治疗上给予GC治疗。比较两组临床观察指标和不良反应及肺功能改善情况。结果观察组的退热时间、咳嗽缓解时间、湿啰音消失时间、X线片恢复时间、住院时间均短于对照组，差异有统计学意义（P＜0.05）；观察组的面部潮红、腹痛、心率加速、皮疹等不良反应总发生率和对照组比较，差异无统计学意义（P＞0.05）。治疗前，两组的 1 秒用力呼气容积（FEV1）、用力肺活量（FVC）、呼气流量峰值（PEF）指标比较，差异无统计学意义（P＞0.05），观察组治疗后的FEV1、FVC、PEF显著高于对照组，差异有统计学意义（P＜0.05）。结论采用GC辅助治疗儿童肺炎支原体大叶性肺炎，可改善患者临床症状，应用价值高。

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	陈远革

关键词 ：糖皮质激素, 肺炎支原体大叶性肺炎, 炎症

Abstract：Objective To investigate the effect of Glucocorticoid adjuvant therapy on Mycoplasma pneumoniae lobar pneumonia in children.Methods A total of 40 cases of children with Mycoplasma pneumoniae lobar pneumonia admitted to our hospital from July to October 2018 were selected as research objects.The patients were divided into control group and observation group by random touching method,20 cases in each group.The control group was received conventional treatment respectively.The observation group was received Glucocorticoid treatment on top of conventional basic treatment.Clinical observation indexes,adverse reactions and pulmonary function improvement were compared between the two groups.Results The fever abatement time,cough relief time,moist rale disappearance time,X-ray recovery time and hospitalization time of the patients in the observation group were shorter than those in the control group,the differences were statistically significant(P＜0.05）;the overall incidence of adverse reactions such as facial flushing,abdominal pain,heart rate acceleration,rash and the control group had no significant difference(P＞0.05）.The first second forced respiratory volame(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF)of the patients in the two groups before treatment had no significant difference(P＞0.05）.FEV1,FVC and PEF in the observation group were significantly higher than those in the control group after treatment(P＜0.05）.Conclusion Glucocorticoid adjuvant therapy for children with Mycoplasma pneumoniae lobar pneumonia can improve the clinical efficacy of patients with high application value.

Key words：

Glucocorticoid')" href="#">

Glucocorticoid Mycoplasma pneumoniae lobar pneumonia

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基金资助:Glucocorticoid;Mycoplasma pneumoniae lobar pneumonia;Inflammation

引用本文:

陈远革. 糖皮质激素辅助治疗儿童肺炎支原体大叶性肺炎的临床效果[J]. 中国当代医药, 2019, 26(17): 95-97.
CHEN Yuan-ge. Clinical study of Glucocorticoid in the treatment of Mycoplasma pneumoniae lobar pneumonia in children. 中国当代医药, 2019, 26(17): 95-97.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2019/V26/I17/95

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