Abstract：Objective To investigate the changes of human leukocyte antigen-B27 and inflammatory indexs in patients with spondyloarthritis (SpA) and its clinical significance.Methods A total of 196 cases of SpA patients admitted to our hospital from January 2014 to December 2018,which met the research conditions,were selected as the SpA group,and 200 cases of healthy physical examination patients who were examined in our hospital during the same period were selected as the healthy control group.Blood HLA-B27,tumor necrosis factor-α (TNF-α),C-reactive protein (CRP),urinary color doppler ultrasound and abdominal orthotopic X-ray were detected.The occurrence of urolithiasis in the two groups was observed and compared.HLA-B27 positive rate,TNF-α and CRP levels of patients with urolithiasis (+)SpA group and patients with urolithiasis (-) SpA group were compared.Results The incidence of urolithiasis in SpA group was 19.89% (35/176),which was higher than 3.00% (6/200) in healthy control group,the difference was statistically significant (P<0.01).The HLA-B27 positive rate in urolithiasis (+) SpA group (82.86%) was higher than that in urolithiasis (-) SpA group (60.99%),the difference was statistically significant (P<0.05).The levels of TNF-α and CRP in urolithiasis (+) SpA group were higher than those in urolithiasis (-) SpA group,the differences were statistically significant (P<0.05).Conclusion The incidence of urolithiasis in patients with SpA is high,the HLA-B27,TNF-α,and CRP have a certain predictive effect on the risk of urolithiasis.
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