Effectiveness of Ziyin Qingre Decoction in the treatment of recurrent oral ulceration with yin deficiency and fire-excess syndrome
LIU Chun-zi1LI Ping2ZHANG Guo-ming1MI Hong-tu2
1.Department of Stomatology，Bao′an District Hospital of Traditional Chinese Medicine in Shenzhen City，Guangdong Province，Shenzhen 518000，China;
2.Department of Pediatrics，Bao′an District Hospital of Traditional Chinese Medicine in Shenzhen City，Guangdong Province，Shenzhen 518000，China
Abstract：Objective To study the effectiveness of Ziyin Qingre Decoction in the treatment of recurrent oral ulceration（ROU）with yin deficiency and fire-excess syndrome.Methods A total of 44 patients of ROU with yin deficiency and fire-excess syndrome treated in our hospital from August to December 2017 were selected as subjects.According to the different treatment methods，they were divided into study group and control group，22 cases in each group.Patients in the study group were treated with Ziyin Qingre Decoction，while those in the control group were treated with conventional therapy.The therapeutic effect was compared between the two groups.Results Before treatment，there were no statistically significant differences in the levels of inflammatory cytokines （interleukin-2 ［IL-2］，interleukin-8 ［IL-8］and tumor necrosis factor ［TNF-α］）between the two groups （P＞0.05）.After treatment，IL-2 levels were higher in the two groups than before treatment，and IL-8 and TNF-α levels were lower in the two groups than those before treatment，however，IL-2 levels was higher in the study group than that in the control group，and IL-8 and TNF-α levels in the study group were lower than those in the control group，the differences were statistically significant（P＜0.05）.Before treatment，there were no statistically significant differences in the levels of various immune cell indicators （CD3+，CD4+，CD8+and CD4+/CD8+）and plasma endothelin-1 between the two groups （P＞0.05）.After treatment，the levels of CD3+，CD4+，CD8+and CD4+/CD8+in both groups were higher than those before treatment，and the levels of plasma endothelin-1 were lower than those before treatment，but the levels of CD3+，CD4+，CD8+and CD4+/CD8+in the study group were higher than those in the control group，and the levels of plasma endothelin-1 were lower than those in the control group，the differences were statistically significant （P＜0.05）.Conclusion The Ziyin Qingre Decoction can remarkably improve the plasma endothelin-1 levels，reduce the inflammatory factors，stabilize the immune cell levels，promote the fast recovery and keep the favorable prognosis.
刘春子1 李 萍2 张国明1 米宏图2. 滋阴清热方治疗阴虚火旺型复发性口腔溃疡的效果[J]. 中国当代医药, 2019, 26(4): 8-13.
LIU Chun-zi1 LI Ping2 ZHANG Guo-ming1 MI Hong-tu2. Effectiveness of Ziyin Qingre Decoction in the treatment of recurrent oral ulceration with yin deficiency and fire-excess syndrome . 中国当代医药, 2019, 26(4): 8-13.
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