摘要目的 探讨奥曲肽联合胃镜治疗消化性溃疡合并上消化道出血的临床效果。方法 选取2017年6月～2019年6月我院收治的82例消化性溃疡合并上消化道出血患者作为研究对象，采用随机数字表法将患者分为观察组和对照组，每组各41例。对照组患者给予胃镜介入治疗，观察组患者在此基础上给予奥曲肽联合治疗，两组患者均给予基础治疗。观察比较两组患者的临床疗效、呕血停止时间、住院时间、48 h 内再出血率、不良反应发生情况。结果 观察组患者的临床治疗总有效率高于对照组，差异有统计学意义（P＜0.05）。观察组患者的呕血停止时间和住院时间均短于对照组，差异有统计学意义（P＜0.05）。观察组患者的48 h 再出血率低于对照组，差异有统计学意义（P＜0.05）。两组患者的不良反应总发生率比较，差异无统计学意义（P＞0.05）。结论 奥曲肽联合胃镜介入治疗消化性溃疡合并上消化道出血的临床效果好，患者呕血停止时间早，住院时间短，48 h 内再出血率低，值得推广应用。
Abstract：Objective To explore the clinical effect of Octreotide combined with gastroscopy in the treatment of peptic ulcer with upper gastrointestinal hemorrhage.Methods Eighty-two patients with peptic ulcer and upper gastrointestinal hemorrhage admitted to the hospital from June 2017 to June 2019 were selected as subjects and divided into observation group and control group according to the random number table method,with 41 cases in each group.Control group was given gastroscopic intervention,and observation group was combined with Octreotide on this basis,and both groups were given basic treatment.The clinical efficacy,stopping time of hematemesis,hospital stay,rebleeding rate within 48h and occurrence of adverse reactions were observed and compared between the two groups.Results The total effective rate of clinical treatment in observation group was higher than that in control group,the difference was statistically significant (P＜0.05).The stopping time of hematemesis and hospital stay in observation group were shorter than those in control group,the differences were statistically significant (P＜0.05).The 48 h rebleeding rate in observation group was lower than that in control group,the difference was statistically significant (P＜0.05).There was no statistically significant difference in the total incidence rate of adverse reactions between the two groups (P＞0.05).Conclusion Octreotide combined with gastroscopic intervention has good clinical effect,early stopping of hematemesis,short hospital stay and low rebleeding rate within 48 h in the treatment of peptic ulcer with upper gastrointestinal hemorrhage,thus it is worthy of popularization and application.
吴可. 奥曲肽联合胃镜介入治疗消化性溃疡合并上消化道出血的临床效果[J]. 中国当代医药, 2020, 27(5): 46-49.
WU Ke. Clinical effect of Octreotide combined with gastroscopic intervention in the treatment of peptic ulcer with upper gastrointestinal hemorrhage. 中国当代医药, 2020, 27(5): 46-49.
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