Clinical effects of application of Rehabilitation New Liquid combined with Omeprazole in treatment of non-Helicobacter pylori infection peptic ulcer
SHI Yan-qing1LIU Bin2ZHANG Meng-meng1ZHOU Ting2XU Fang2ZHANG Juan3▲
1.Department of Gastroenterology,Affiliated Hospital of Jiujiang University,Jiangxi Province,Jiujiang 332000,China;
2.The Second Department of Gastroenterology,People′s Hospital in Chaisang District of Jiujiang City,Jiangxi Province,Jiujiang 332000,China;
3.Department of Stomatology,Affiliated Hospital of Jiujiang University,Jiangxi Province,Jiujiang 332000,China
Abstract：Objective To explore the clinical efficacy of Rehabilitation New Liquid combined with Omeprazole in the treatment of non-Helicobacter pylori infection peptic ulcer.Methods Altogether 84 patients with peptic ulcer who met the requirements in Affiliated Hospital of Jiujiang University from January 2017 to April 2018 were selected as subjects and randomly divided into case group and control group,with 42 cases in each group.The control group was treated with Omeprazole,while the case group was treated with Rehabilitation New Liquid combined with Omeprazole.The clinical effects of the two groups were observed and compared.The levels of inflammatory cytokines were measured before and after treatment in both groups.The adverse reactions of the two groups were compared.The recurrence of gastric ulcer was compared between the two groups during follow-up.Results The total effective rate of the patients in the case group was 95.24%,which was higher than that in the control group (78.57%),and the difference was statistically significant(P＜0.05).The levels of interleukin-6(IL-6),tumor necrosis factor α (TNF-α)and C-reactive protein(CRP)in the two groups before treatment were not statistically significant(P＞0.05),while the levels of IL-6,TNF-α and CRP after treatment were lower than before treatment,and the differences were statistically significant(P＜0.05).The levels of IL-6,TNF-α and CRP in the case group after treatment were lower than those in the control group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the overall incidence of adverse reactions between the two groups(P＞0.05).Gastroscopy review after 2 months of follow-up showed that the recurrence rate of patients in the case group(4.76%)was lower than that in the control group(19.05%),and the difference was statistically significant(P＜0.05).Conclusion Rehabilitation New Liquid combined with Omeprazole is effective in the treatment of peptic ulcer,which has synergistic effect and is worthy of clinical promotion.
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